Deletion of Lats 1 and 2 in mouse pancreatic acinar cells induces pancreatic fibrosis and inflammation

Autor: M Gao, M Nipper, RL Johnson, P Wang, J Liu, HC Crawford, YD Chen, FE Sharkey

ObjectiveThe Hippo signaling pathway is known for regulating proliferation, differentiation, organ size, and tumorigenesis. Large tumor suppressor kinase 1 and 2 (LATS1&2) are the core kinases of this pathway, whose functions in both the normal pancr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10777015a8df8b81d1cd2a40f6b302fc
https://doi.org/10.1101/522938

Tumor-Associated Carbohydrate Antigen 19-9 (CA 19-9), a Promising Target for Antibody-Based Detection, Diagnosis, and Immunotherapy of Cancer.

Autor: Nakisa A; Department of Chemistry, Michigan State University, East Lansing, Michigan, 48824, United States.; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan, 48824, United States., Sempere LF; Precision Health Program and Department of Radiology, Michigan State University, East Lansing, Michigan, 48824, United States., Chen X; Department of Chemistry, University of California, Davis, California, 95616, USA., Qu LT; Department of Surgery, Michigan State University, East Lansing, Michigan, 48824, United States., Woldring D; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan, 48824, United States.; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan, 48824, United States., Crawford HC; Department of Surgery, Henry Ford Health System, Detroit, Michigan, 48202, United States.; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, 48824, United States., Huang X; Department of Chemistry, Michigan State University, East Lansing, Michigan, 48824, United States.; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan, 48824, United States.; Department of Biomedical Engineering, Michigan State University, East Lansing, Michigan, 48824, United States.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Sep 04, pp. e202400491. Date of Electronic Publication: 2024 Sep 04.

Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer.

Autor: Salas-Escabillas DJ; Cancer Biology, University of Michigan, Ann Arbor, MI.; Department of Surgery, Henry Ford Health, Detroit, MI., Hoffman MT; Department of Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Moore JS; Department of Surgery, Henry Ford Health, Detroit, MI., Brender SM; Department of Surgery, Henry Ford Health, Detroit, MI., Wen HJ; Department of Surgery, Henry Ford Health, Detroit, MI., Benitz S; Department of Surgery, Henry Ford Health, Detroit, MI., Davis ET; Department of Surgery, Henry Ford Health, Detroit, MI., Long D; Department of Surgery, Henry Ford Health, Detroit, MI., Wombwell AM; Department of Surgery, Henry Ford Health, Detroit, MI., Steele NG; Department of Surgery, Henry Ford Health, Detroit, MI., Sears RC; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR., Matsumoto I; Monell Chemical Senses Center, Philadelphia, PA., DelGiorno KE; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN., Crawford HC; Department of Surgery, Henry Ford Health, Detroit, MI.; Cancer Biology Program, Wayne State University, Detroit, MI.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 23. Date of Electronic Publication: 2024 Apr 23.

Pancreatic Ubap2 deletion regulates glucose tolerance, inflammation, and protection from cerulein-induced pancreatitis.

Autor: Roy RV; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Means N; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Rao G; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Asfa S; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Madka V; Center for Cancer Prevention and Drug Development, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Dey A; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Zhang Y; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Choudhury M; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Fung KM; Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Dhanasekaran DN; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Cell Biology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA., Friedman JE; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Crawford HC; Department of Surgery, Henry Ford Pancreatic Cancer Center, Henry Ford Health System, Detroit, MI, USA., Rao CV; Center for Cancer Prevention and Drug Development, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Bhattacharya R; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA., Mukherjee P; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: Priyabrata-Mukherjee@ouhsc.edu.

Publikováno v: Cancer letters [Cancer Lett] 2023 Dec 01; Vol. 578, pp. 216455. Date of Electronic Publication: 2023 Oct 19.

scRNA-Seq and imaging mass cytometry analyses unveil iNKT cells-mediated anti-tumor immunity in pancreatic cancer liver metastasis.

Autor: Yi Q; Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, 48202, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, 48202, USA., Wang J; Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, 48202, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, 48202, USA., Liu T; Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, 48202, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, 48202, USA., Yao Y; Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, 48202, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, 48202, USA., Loveless I; Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, 48202, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, 48202, USA; Center for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, MI, 48202, USA., Subedi K; Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, 48202, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, 48202, USA., Toor J; Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, 48202, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, 48202, USA., Adrianto I; Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, 48202, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, 48202, USA; Center for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, MI, 48202, USA; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, 48824, USA., Xiao H; Department of Physiology, College of Natural Science, Michigan State University, East Lansing, MI, 48824, USA., Chen B; Department of Pediatrics and Human Development, Michigan State University, Grand Rapids, MI, USA., Crawford HC; Henry Ford Pancreatic Cancer Center, Department of Surgery, Henry Ford Health, Detroit, MI, 48202, USA., Fang D; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Zhou L; Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, 48202, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, 48202, USA; Center for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, MI, 48202, USA; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, 48824, USA; Department of Internal Medicine, Henry Ford Health, Detroit, MI, 48202, USA. Electronic address: lzhou1@hfhs.org., Mi QS; Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI, 48202, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, 48202, USA; Center for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, MI, 48202, USA; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, 48824, USA; Department of Internal Medicine, Henry Ford Health, Detroit, MI, 48202, USA. Electronic address: QMI1@hfhs.org.

Publikováno v: Cancer letters [Cancer Lett] 2023 May 01; Vol. 561, pp. 216149. Date of Electronic Publication: 2023 Mar 27.