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Akademický článek

A high functional cure rate was induced by pegylated interferon alpha-2b treatment in postpartum hepatitis B e antigen-negative women with chronic hepatitis B virus infection: an exploratory study

Autor: Wenting Zhong, Lanzhi Yan, Yage Zhu, Lei Shi, Yingli He, Tianyan Chen, Jie Zheng

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Background and aimsLimited data have been reported on achieving functional cure using pegylated interferon (Peg-IFN) alpha-2b treatment for postpartum hepatitis B e antigen (HBeAg)-negative women with chronic hepatitis B virus (HBV) infection. This s

Externí odkaz: https://doaj.org/article/4a3fff43db384556bcaa435c54dca13f

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Akademický článek

Interferon-α could induce liver steatosis to promote HBsAg loss by increasing triglyceride level

Autor: Lili Wu, Zhihui Li, Na Gao, Hong Deng, Qiyi Zhao, Zhaoxia Hu, Junfeng Chen, Ziying Lei, Jinhua Zhao, Bingliang Lin, Zhiliang Gao

Publikováno v: Heliyon, Vol 10, Iss 12, Pp e32730- (2024)

Background: The correlation between metabolic syndrome (MetS) and hepatitis B surface antigen (HBsAg) loss remains to be further elucidated, particularly in patients receiving pegylated interferon-α (PEG-IFN) treatment. Methods: 758 patients with lo

Externí odkaz: https://doaj.org/article/398183e08969426ebae9dc03bc31277e

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Akademický článek

Interferon-α could induce liver steatosis to promote HBsAg loss by increasing triglyceride level

Autor: Wu, Lili ^{a, b, 1}, Li, Zhihui ^{a, b, 1}, Gao, Na ^{a, b, 1}, Deng, Hong ^{a, b}, Zhao, Qiyi ^{a, b}, Hu, Zhaoxia ^{a, b}, Chen, Junfeng ^{a, b}, Lei, Ziying ^{a, b}, Zhao, Jinhua ^{a, b}, Lin, Bingliang ^{a, b, ⁎⁎}, Gao, Zhiliang ^{a, b, c, ⁎}

Publikováno v: In Heliyon 30 June 2024 10(12)

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Akademický článek

The occurrence of immune-related adverse events is an independent risk factor both for serum HBsAg increase and HBV reactivation in HBsAg-positive cancer patients receiving PD-1 inhibitor combinational therapy

Autor: Yingfu Zeng, Jiwei Huang, Jiahui Pang, Shufang Pan, Yuankai Wu, Yusheng Jie, Xinhua Li, Yutian Chong

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundPrevious studies have suggested the potential of PD-1/PD-L1 inhibitors in the treatment of chronic HBV infection. However, since phase III clinical trials have not yet been announced, additional clinical insights may be obtained by observin

Externí odkaz: https://doaj.org/article/977bd226ddbc4a109c2b8f533c0d18a2

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Akademický článek

Predictive value of Th17 and Treg cells at baseline for HBsAg loss in chronic hepatitis B patients with low HBsAg quantification treated with pegylated interferon and nucleos(t)ide analogue

Autor: Li-Li Wu, Xiao-Yan Li, Kai Deng, Bing-Liang Lin, Hong Deng, Dong-Ying Xie, Geng-Lin Zhang, Qi-Yi Zhao, Zhi-Shuo Mo, Yue-Hua Huang, Zhi-Liang Gao

Publikováno v: Liver Research, Vol 7, Iss 2, Pp 136-144 (2023)

Background and aims: The primary goal of chronic hepatitis B (CHB) treatment is to reduce hepatitis B surface antigen (HBsAg). T helper 17 (Th17) and regulatory T (Treg) cells are essential for the development of CHB. However, how Th17 and Treg cells

Externí odkaz: https://doaj.org/article/8d959db95e01445fb794174860636754

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Akademický článek

Clinical Consequences of Hepatitis B Surface Antigen Loss in Chronic Hepatitis B Infection: A Systematic Literature Review and Meta-Analysis

Autor: Eleonora Morais, Lauren Mason, John Dever, Pam Martin, Jing Voon Chen, Leigh Felton, Stuart Kendrick, Dickens Theodore, Iain A. Gillespie

Publikováno v: Gastro Hep Advances, Vol 2, Iss 7, Pp 992-1004 (2023)

Background and Aims: Functional cure, which requires sustained hepatitis B surface antigen (HBsAg) loss after treatment cessation, is currently the optimal treatment endpoint for chronic hepatitis B virus infection. We performed a systematic literatu

Externí odkaz: https://doaj.org/article/6cb30bf451c34250852a02f751552273

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Akademický článek

Lower pretreatment HBV DNA levels are associated with better off-treatment outcomes after nucleo(s)tide analogue withdrawal in patients with HBeAg-neegative chronic hepatitis B: A multicentre cohort study

Publikováno v: JHEP Reports, Vol 5, Iss 8, Pp 100790- (2023)

Background & Aims: Pretreatment predictors of finite nucleo(s)tide analogue (NUC) therapy remain elusive. We studied the association between pretreatment HBV DNA levels and outcomes after therapy cessation. Methods: Patients with chronic hepatitis B

Externí odkaz: https://doaj.org/article/ed567dc91f3c4d328c67f9acb5bbb743

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Akademický článek

Kinetics and Value of Hepatitis B Core-Related Antigen in Patients with Chronic Hepatitis B Virus Infection during Antiviral Treatment

Autor: Lisa Sandmann, Birgit Bremer, Valerie Ohlendorf, Jerzy Jaroszewicz, Heiner Wedemeyer, Markus Cornberg, Benjamin Maasoumy

Publikováno v: Viruses, Vol 16, Iss 2, p 255 (2024)

Background: The hepatitis B core-related antigen (HBcrAg) correlates with HBV DNA in patients with chronic HBV infection without antiviral treatment. Its utility in monitoring patients during and after the cessation of nucleos(t)ide analog (NA) treat

Externí odkaz: https://doaj.org/article/d70548208fc34980b7b2902bda2317a3

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