Výsledky vyhledávání - "HBV polymerase"

Molecular Characterization of Hepatitis B Virus Strains Isolated from Chronic Hepatitis B Patients in Southeastern Region of Turkey

Autor: Suda Tekin, Murat Sayan, Sıla Akhan, Mehtap Aydin

Publikováno v: Viral Hepatitis Journal

Objectives: the aim of the present study was to assess the molecular aspects of HBV strains isolated from chronic hepatitis B (CHB) patients, in the Southeastern region of Turkey. Materials and methods: the study involved a total of 110 patients, 57

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5925358518e01da1ddc444dee031a384
https://doi.org/10.4274/vhd.galenos.2019.2019.0015

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HBV mutations in EnhII/BCP/PC region contribute to the prognosis of hepatocellular carcinoma

Autor: Ci Song, Juncheng Dai, Xin Xu, Chengxiao Yu, Lijuan Meng, Jibin Liu, Zijun Ge, Ting Tian, Zhibin Hu

Publikováno v: Cancer Medicine, Vol 8, Iss 6, Pp 3086-3093 (2019)
Cancer Medicine

Background Accompanied by HBV infection, HBV mutations gradually occur because HBV polymerase appears proofread deficiencies. In our previous study, we have identified that EnhII/BCP/PC mutations and genotype C of HBV DNA were associated with hepatoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c05897a5281d5969713dc9a6341097d
https://doaj.org/article/b3f1366bb2d44bbd92f4ab199d25e06c

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A novel therapeutic HBV vaccine candidate induces strong polyfunctional cytotoxic T cell responses in mice

Autor: Robbert Boudewijns, Johan Neyts, Kai Dallmeier, Ji Ma

Publikováno v: JHEP Reports
JHEP Reports, Vol 3, Iss 4, Pp 100295-(2021)

Background & Aims Current standard-of-care suppresses HBV replication, but does not lead to a functional cure. Treatment aiming to cure chronic hepatitis B (CHB) is believed to require the induction of strong cellular immune responses, such as by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa6a662c3c140792ac90ba2679e0c6e
http://europepmc.org/articles/PMC8203848

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High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy

Autor: Taotao Yan, Naijuan Yao, Jinfeng Liu, Chunhua Hu, Qiang Yu, Li Jin, Yingli He, Yingren Zhao, Jing Wang, Jie Zheng, Yuan Yang, Tianyan Chen

Publikováno v: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale
Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 2021 (2021)

Background. HBV-resistant mutants in treatment-naïve patients may lead to antiviral treatment failure. It is not clear if HBV mutants are present in pregnant women and about the influence of the preexisting mutants on the short-term antiviral therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c0556d873503a35a1c49f2d94bb877
http://europepmc.org/articles/PMC8079218

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High prevalence of pre-existing HBV polymerase mutations in pregnant women do not limit the telbivudine treatment efficacy

Autor: Tianyan Chen, Jinfeng Liu, Qiang Yu, Jing Wang, Li Jin, Yingli He, Chunhua Hu, Jie Zheng, Yingren Zhao, Taotao Yan, Yuan Yang, Naijuan Yao

Background: HBV resistant mutants in treatment-naïve patients may lead to antiviral treatment failure. It’s not clear if HBV resistant mutants present in the pregnant women before the antiviral treatment and the influence of the pre-existing resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a34116826e554be762f234db8f014511
https://doi.org/10.21203/rs.3.rs-44747/v1

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Establishment of a system for finding inhibitors of ε RNA binding with the HBV polymerase

Autor: Eriko Ohsaki, Keiji Ueda, Xiao‐Quan Liu

Publikováno v: Genes to Cells

Although several nucleo(s)tide analogs are available for treatment of HBV infection, long‐term treatment with these drugs can lead to the emergence of drug‐resistant viruses. Recent HIV‐1 studies suggest that combination therapies using nucleo(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e269a6d63788ba60e7721353b68d3c
https://pubmed.ncbi.nlm.nih.gov/32415897

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HBV Polymerase as a Target for Development of Anti-HBV Drugs

Autor: Satish B. Bhise

The chapter describes the role of enzyme hepatitis B virus (HBV) polymerase as a target for development of anti-HBV drugs. Introduction gives a brief background about epidemiology of HBV. Structure and genome of HBV are described. The mechanism of re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4464b54c13c8090795117b4fbf34e58
https://doi.org/10.1016/b978-0-12-815422-9.00009-7

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