Gintonin influences the morphology and motility of adult brain neurons via LPA receptors

Autor: Hyewhon Rhim, Do-Geun Kim, Sun Hye Choi, Seung Yeol Nah, Man Hee Rhee, Ik Hyun Cho, Sung Min Nam, Hyoung-Chun Kim, Hyeon-Joong Kim

Publikováno v: Journal of Ginseng Research
Journal of Ginseng Research, Vol 45, Iss 3, Pp 401-407 (2021)

Background Gintonin is an exogenous ginseng-derived G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. LPA induces in vitro morphological changes and migration through neuronal LPA1 receptor. Recently, we reported that systemic administra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7b35c04d99638d6b8e1671517e2368
https://doi.org/10.1016/j.jgr.2020.06.003

The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties

Autor: Karan M. Shah, Elena Adinolfi, Elena De Marchi, Archana Singh, Luke Tattersall, Alex Williamson, Jennifer M. Down, William D. Fraser, Alison Gartland, Francesco Di Virgilio, Michelle A. Lawson, Dominique Heymann, Darren Lath, Darrell Green

Publikováno v: Journal of Bone Oncology
Journal of Bone Oncology, 2021, 31, pp.100398. ⟨10.1016/j.jbo.2021.100398⟩
Journal of Bone Oncology, Vol 31, Iss, Pp 100398-(2021)

Osteosarcoma (OS) is the most common type of primary bone cancer affecting children and adolescents. OS has a high propensity to spread, meaning the disease is often incurable and fatal. There have been no improvements in survival rates for decades.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b702ba5c427745d1727816023f8ed9a8
https://eprints.whiterose.ac.uk/179999/1/1-s2.0-S2212137421000531-main.pdf

Direct coupling of oligomerization and oligomerization-driven endocytosis of the dopamine transporter to its conformational mechanics and activity

Autor: Tarique Rajasaheb Bagalkot, Tatiana Sorkina, Ivet Bahar, Simon C. Watkins, Mary Hongying Cheng, Alexander Sorkin, Callen T. Wallace

Publikováno v: The Journal of Biological Chemistry

Dopamine transporter (DAT) mediates the reuptake of synaptically released dopamine, and thus controls the duration and intensity of dopamine neurotransmission. Mammalian DAT has been observed to form oligomers, although the mechanisms of oligomerizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea485c6f951547b4951a21b116fc66c1
https://pubmed.ncbi.nlm.nih.gov/33610553

Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein

Autor: John Paul Fawcett, Tingting Wang, Yang He, Tianming Ren, Lei Yin, Huimin Sun, Yingjie Guo, Jingkai Gu

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 2002-2009 (2020)

Polyethylene glycols (PEGs) in general use are polydisperse molecules with molecular weight (MW) distributed around an average value applied in their designation e.g., PEG 4000. Previous research has shown that PEGs can act as P-glycoprotein (P-gp) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67944d5d71e648ebb23f796d4bcd2c2c
https://pubmed.ncbi.nlm.nih.gov/33163350

Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

Autor: Celine Valant, Patrick M. Sexton, Elham Khajehali, Peter J. Scammells, Manuela Jörg, Craig W. Lindsley, Arthur Christopoulos, Andrew B. Tobin, P. Jeffrey Conn

Publikováno v: Biochemical Pharmacology

Graphical abstract
Subtype-selective allosteric modulation of the M1 muscarinic acetylcholine (ACh) receptor (M1 mAChR) is an attractive approach for the treatment of numerous disorders, including cognitive deficits. The discovery of benzyl quin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9825fb21ad2045775ecf4d26ab83b0c2
https://eprints.gla.ac.uk/163141/1/163141.pdf