A mathematical model for evaluating the role of trypanocide treatment of cattle in the epidemiology and control of Trypanosoma brucei rhodesiense and T. b. gambiense sleeping sickness in Uganda

Autor: Julianne Meisner, Peter M. Rabinowitz, Ruanne V. Barnabas

Publikováno v: Parasite Epidemiology and Control
Parasite Epidemiology and Control, Vol 5, Iss, Pp-(2019)

Background Human and animal African trypanosomiases impose a large economic and health burden in their endemic regions. Large strides have been made in the control of human African trypanosomiasis (HAT), yet these efforts have largely focused on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3fbd41975afbccb986166adff907d8
http://europepmc.org/articles/PMC6487357

An insight of sleep disorders in Africa

Autor: Alberto K. De la Herrán-Arita, David A. Armienta-Rojas, César A. Moreno-Villegas, Jorge F. Aragón-Arreola

Publikováno v: eNeurologicalSci, Vol 3, Iss C, Pp 37-40 (2016)
eNeurologicalSci

Sleep is a recurrent physiologic and fundamental process in every human being, regardless of ethnicity, gender, birthplace, or occupation; however, the features of sleep are swayed by genetic background and environmental influences. All these factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803d71373359e83d75d647f280068943

Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity

Autor: Papadopoulou, Maria V., Bloomer, William D., Rosenzweig, Howard S., Wilkinson, Shane R., Szular, Joanna, Kaiser, Marcel

Publikováno v: European Journal of Medicinal Chemistry

3-Nitro-1H-1,2,4-triazole-based acetamides bearing a biphenyl- or a phenoxyphenyl moiety have shown remarkable antichagasic activity both in vitro and in an acute murine model, as well as substantial in vitro antileishmanial activity but lacked activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9360352d86c10d572924880a6f286ac1
http://europepmc.org/articles/PMC5049494

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi

Autor: Alan H. Fairlamb, Wing-Huen A. Chow, Deuan C. Jones, Sandra L. Oza, Antonio Ariza

Publikováno v: Molecular and Biochemical Parasitology

As part of a drug discovery programme to discover new treatments for human African trypanosomiasis, recombinant trypanothione reductase from Trypanosoma brucei has been expressed, purified and characterized. The crystal structure was solved by molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a331187e5610b0eb07e45c6a9b6e19b8
http://ora.ox.ac.uk/objects/uuid:

In vitro effects and mechanisms of action of Bidens pilosa in Trypanosoma brucei .

Autor: Dofuor AK; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana.; Department of Biological, Physical and Mathematical Sciences, University of Environment and Sustainable Development, Somanya, Ghana., Djameh GI; Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Amoa-Bosompem M; Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Kwain S; Marine and Plant Research Laboratory of Ghana, Department of Chemistry, University of Ghana, Legon, Ghana., Osei E; Marine and Plant Research Laboratory of Ghana, Department of Chemistry, University of Ghana, Legon, Ghana., Tetevi GM; Marine and Plant Research Laboratory of Ghana, Department of Chemistry, University of Ghana, Legon, Ghana., Ayertey F; Center for Plant Medicine Research, Mampong-Akuapem, Ghana., Bolah P; Center for Plant Medicine Research, Mampong-Akuapem, Ghana., Okine LK; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana.; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Ghana., Kyeremeh K; Marine and Plant Research Laboratory of Ghana, Department of Chemistry, University of Ghana, Legon, Ghana., Gwira TM; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana.; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Ghana., Ohashi M; Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.; Department of Environmental Parasitology, Tokyo Medical and Dental University, Tokyo, Japan.

Publikováno v: Journal of traditional and complementary medicine [J Tradit Complement Med] 2021 Aug 11; Vol. 12 (3), pp. 260-268. Date of Electronic Publication: 2021 Aug 11 (Print Publication: 2022).