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Autor:
Joseph Veyhl, Robert J Dunn, Wendy L Johnston, Alexa Bennett, Lijia W Zhang, James W Dennis, Harry Schachter, Joseph G Culotti
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183049 (2017)
Glycoproteins such as growth factor receptors and extracellular matrix have well-known functions in development and cancer progression, however, the glycans at sites of modification are often heterogeneous molecular populations which makes their func
Externí odkaz:
https://doaj.org/article/0a3cd235050f44908f27406dc15e0633
Autor:
Reza Beheshti Zavareh, Mahadeo A Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Craig D Simpson, Neil Maclean, Francis Zih, Troy Ketela, Carol J Swallow, Jason Moffat, David R Rose, Harry Schachter, Aaron D Schimmer, James W Dennis
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e43721 (2012)
Oncogenic signaling promotes tumor invasion and metastasis, in part, by increasing the expression of tri- and tetra- branched N-glycans. The branched N-glycans bind to galectins forming a multivalent lattice that enhances cell surface residency of gr
Externí odkaz:
https://doaj.org/article/76ee1fcc2d2a4fbda66813266fae872d
Autor:
Shi Yan, Huijie Wang, Iain B. H. Wilson, Harry Schachter, Chunsheng Jin, Katharina Paschinger
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2191-2203
The modification in the Golgi of N-glycans by N-acetylglucosaminyltransferase I (GlcNAc-TI, MGAT1) can be considered to be a hallmark of multicellular eukaryotes as it is found in all metazoans and plants, but rarely in unicellular organisms. The enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad29c3bd77725b0d2f1140d696418286
https://doi.org/10.1016/j.bbagen.2018.07.002
https://doi.org/10.1016/j.bbagen.2018.07.002
Autor:
Harry Schachter
Publikováno v:
Glycoconjugate Journal. 31:1-5
The synthesis of complex asparagine-linked glycans (N-glycans) involves a multi-step process that starts with a five mannose N-glycan structure: [Manα1-6(Manα1-3)Manα1-6][Manα1-3]-R where R = Manβ1-4GlcNAcβ1-4GlcNAcβ1-Asn-protein. N-acetylgluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd3a59e381d510a433f9588c9551cfc
https://doi.org/10.1007/s10719-013-9507-5
https://doi.org/10.1007/s10719-013-9507-5
Autor:
James W. Dennis, Lijia W. Zhang, Joseph G. Culotti, Wendy L. Johnston, Alexa Bennett, Joseph Veyhl, Harry Schachter, Robert J. Dunn
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0183049 (2017)
PLoS ONE, Vol 12, Iss 8, p e0183049 (2017)
Glycoproteins such as growth factor receptors and extracellular matrix have well-known functions in development and cancer progression, however, the glycans at sites of modification are often heterogeneous molecular populations which makes their func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce79474f4359717c006bc8a670d9479b
https://pubmed.ncbi.nlm.nih.gov/28817611
https://pubmed.ncbi.nlm.nih.gov/28817611
Publikováno v:
Fly. 5:18-24
N-glycans are post-translational modifications in which the sugar chain is covalently linked to protein by a GlcNAcβ1-N-asparagine linkage. Drosophila melanogaster and other invertebrates, but not vertebrates, synthesize large amounts of "paucimanno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51c2ac306ea4aa61cf0cf721f4f385f6
https://doi.org/10.4161/fly.5.1.13920
https://doi.org/10.4161/fly.5.1.13920
Autor:
Peter A. Leventis, Mohan Sarkar, Gabrielle L. Boulianne, Konstantin G. Iliadi, Harry Schachter
Publikováno v:
Proceedings of the National Academy of Sciences. 107:9677-9682
The enzyme UDP-GlcNAc:α3-D-mannoside β1,2- N -acetylglucosaminyltransferase I (GnT1, encoded by Mgat1 ) controls the synthesis of paucimannose N -glycans in Drosophila . We have previously reported that null mutations in Drosophila Mgat1 are viable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7314be7d5d034e033f2b7d57bc54c0f
https://doi.org/10.1073/pnas.1004431107
https://doi.org/10.1073/pnas.1004431107
Autor:
Hudson H. Freeze, Harry Schachter
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1792:925-930
About 250 to 500 glycogenes (genes that are directly involved in glycan assembly) are in the human genome representing about 1–2% of the total genome. Over 40 human congenital diseases associated with glycogene mutations have been described to date
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8237d366ab526549d3e0ce5e4d04972c
https://doi.org/10.1016/j.bbadis.2008.11.002
https://doi.org/10.1016/j.bbadis.2008.11.002
Autor:
Harry Schachter
Publikováno v:
Trends in Glycoscience and Glycotechnology. 21:131-148
線虫には約 150 種類の N 型糖鎖の存在が判明している。本稿では，無脊椎動物に多く存在し，脊椎動物にないパウチマンノース型 N-グリカンの合成と機能について考察する。線虫の糖鎖
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be70be55253e95ad5690db429fb885ee
https://doi.org/10.4052/tigg.21.131
https://doi.org/10.4052/tigg.21.131