Fusion Loop Peptide of the West Nile Virus Envelope Protein Is Essential for Pathogenesis and Is Recognized by a Therapeutic Cross-Reactive Human Monoclonal Antibody

Autor: Theodore Oliphant, Hameeda Sultana, Michael Engle, Harald G. Foellmer, Nathalie Bonafé, Wayne A. Marasco, Paul Kaplan, Michel Ledizet, Raymond A. Koski, Manoj N. Krishnan, Michael S. Diamond, Erol Fikrig, Girish Neelakanta, Karen Anthony, Ruth R. Montgomery

Publikováno v: The Journal of Immunology. 183:650-660

West Nile virus is an emerging pathogen that can cause fatal neurological disease. A recombinant human mAb, mAb11, has been described as a candidate for the prevention and treatment of West Nile disease. Using a yeast surface display epitope mapping

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5ebc8d043db451e8236e1b667ea9d5
https://doi.org/10.4049/jimmunol.0900093

A West Nile Virus Recombinant Protein Vaccine That Coactivates Innate and Adaptive Immunity

Autor: James W. Huleatt, Duane D. Hewitt, Erol Fikrig, Yan Huang, Jie Tang, Mcdonald William F, Andrea Jacobs, Lena Alexopoulou, Virginia N Takahashi, Valerian Nakaar, Harald G. Foellmer, T.J. Powell, Albert E. Price, Priyanka Desai

Publikováno v: Journal of Infectious Diseases
Journal of Infectious Diseases, Oxford University Press (OUP), 2007, 195 (11), pp.1607-17. ⟨10.1086/517613⟩
Journal of Infectious Diseases, 2007, 195 (11), pp.1607-17. ⟨10.1086/517613⟩

A chimeric protein West Nile virus (WNV) vaccine capable of delivering both innate and adaptive immune signals was designed by fusing a modified version of bacterial flagellin (STF2 Delta ) to the EIII domain of the WNV envelope protein. This fusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7dff4e3e235f7a6ceec6504862b6b2
https://doi.org/10.1086/517613

Differential Regulation and Function of the Fas/Fas Ligand System in Human Trophoblast Cells1

Autor: Karlijn M.A. Verwer, Sarit Aschkenazi, Harald G. Foellmer, Shawn Straszewski, Thomas J. Rutherford, Gil Mor

Publikováno v: Biology of Reproduction. 66:1853-1861

Trophoblast rejection, which is characterized by increased apoptosis, is mediated by T helper (Th)-1, or proinflammatory, cytokines, whereas Th-2, or anti-inflammatory, cytokines confer immune protection and facilitate implantation. We investigated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac381bbdca9bd72347e2611e4463d4c8
https://doi.org/10.1095/biolreprod66.6.1853

Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling

Autor: Raymond A. Koski, Girish Neelakanta, Hameeda Sultana, Ruth R. Montgomery, Ruslan Medzhitov, Erol Fikrig, Harald G. Foellmer, John F. Anderson

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 189(6)

Semaphorin 7A (Sema7A) is a membrane-associated/secreted protein that plays an essential role in connecting the vertebrate neuronal and immune systems. However, the role of Sema7A has not been elucidated in viral pathogenesis. In this study, we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059d18de32de819ec4c22efff67cdf21
https://pubmed.ncbi.nlm.nih.gov/22896629

A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells

Autor: Karen Anthony, Stacey Fader, Michel Ledizet, Joseph A. Rininger, Harald G. Foellmer, Paul Kaplan, Nathalie Bonafé, Raymond A. Koski, Sandra L. Bushmich, Richard Chubet, Erol Fikrig, John F. Anderson

Publikováno v: Vaccine. 27(2)

In this study, a recombinant truncated West Nile virus envelope protein antigen (rWNV-E) was produced in serum-free cultures of the expresSF+ insect cell line via baculovirus infection. This production system was selected based on its use in the prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6424d1a38494c5fe86cedaaf866f9046
https://pubmed.ncbi.nlm.nih.gov/18996430