Výsledky vyhledávání - "HANS SCHÖLER"

Akademický článek

The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice

Autor: Anke Hermann, Guangming Wu, Pavel I. Nedvetsky, Viktoria C. Brücher, Charlotte Egbring, Jakob Bonse, Verena Höffken, Dirk Oliver Wennmann, Matthias Marks, Michael P. Krahn, Hans Schöler, Peter Heiduschka, Hermann Pavenstädt, Joachim Kremerskothen

Publikováno v: Cell Death and Disease, Vol 12, Iss 1, Pp 1-14 (2021)

Abstract The WW-and-C2-domain-containing (WWC) protein family is involved in the regulation of cell differentiation, cell proliferation, and organ growth control. As upstream components of the Hippo signaling pathway, WWC proteins activate the Large

Externí odkaz: https://doaj.org/article/5558975e38b6443abbd9e8c7c04cf744

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Akademický článek

Generation and Maintenance of Homogeneous Human Midbrain Organoids

Autor: Henrik Renner, Martha Grabos, Hans Schöler, Jan Bruder

Publikováno v: Bio-Protocol, Vol 11, Iss 11 (2021)

Three-dimensional cell cultures (“organoids”) promise to better recapitulate native tissue physiology than traditional 2D cultures and are becoming increasingly interesting for disease modeling and compound screening efforts. While a number of pr

Externí odkaz: https://doaj.org/article/f00fb6a6bba9473594f7951a5e9024e2

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Akademický článek

Fluorescence-based Single-cell Analysis of Whole-mount-stained and Cleared Microtissues and Organoids for High Throughput Screening

Autor: Henrik Renner, Mandy Otto, Martha Grabos, Hans Schöler, Jan Bruder

Publikováno v: Bio-Protocol, Vol 11, Iss 12 (2021)

Three-dimensional (3D) cell culture, especially in the form of organ-like microtissues (“organoids”), has emerged as a novel tool potentially mimicking human tissue biology more closely than standard two-dimensional culture. Typically, tissue sec

Externí odkaz: https://doaj.org/article/034893d320c941ba94cc71c6acf9055b

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Akademický článek

Systematic analysis of gene expression differences between left and right atria in different mouse strains and in human atrial tissue.

Autor: Peter C Kahr, Ilaria Piccini, Larissa Fabritz, Boris Greber, Hans Schöler, Hans H Scheld, Andreas Hoffmeier, Nigel A Brown, Paulus Kirchhof

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26389 (2011)

BackgroundNormal development of the atria requires left-right differentiation during embryonic development. Reduced expression of Pitx2c (paired-like homeodomain transcription factor 2, isoform c), a key regulator of left-right asymmetry, has recentl

Externí odkaz: https://doaj.org/article/f74f611bba404314a1e1f5db69086b99

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Akademický článek

The PluriNetWork: an electronic representation of the network underlying pluripotency in mouse, and its applications.

Autor: Anup Som, Clemens Harder, Boris Greber, Marcin Siatkowski, Yogesh Paudel, Gregor Warsow, Clemens Cap, Hans Schöler, Georg Fuellen

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15165 (2010)

BACKGROUND: Analysis of the mechanisms underlying pluripotency and reprogramming would benefit substantially from easy access to an electronic network of genes, proteins and mechanisms. Moreover, interpreting gene expression data needs to move beyond

Externí odkaz: https://doaj.org/article/ae1434321f104fbaabb8043ab75d58f8

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