Zobrazeno 1 - 10
of 77
pro vyhledávání: '"HA-stalk"'
Autor:
Eduard Puente-Massaguer, Annika Beyer, Madhumathi Loganathan, Iden Sapse, Juan Manuel Carreño, Goran Bajic, Weina Sun, Peter Palese, Florian Krammer
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Seasonal influenza viruses account for 1 billion infections worldwide every year, including 3–5 million cases of severe illness and up to 650,000 deaths. The effectiveness of current influenza virus vaccines is variable and relies on the immunodomi
Externí odkaz:
https://doaj.org/article/79d4755682f742bc909d6415d153112d
Autor:
Sonia Jangra, Gabriel Laghlali, Angela Choi, Raveen Rathnasinghe, Yong Chen, Soner Yildiz, Lynda Coughlan, Adolfo García-Sastre, Bruno G. De Geest, Michael Schotsaert
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Influenza vaccine effectiveness could be improved by combination with an adjuvant with the potential to enhance the host-vaccine response both quantitatively and qualitatively. The goal of this study was to explore a RIG-I agonist (SDI-nanogel) and a
Externí odkaz:
https://doaj.org/article/8948680f21d34497a5a69b874b6560f4
Akademický článek
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Autor:
Daniel E Demminger, Lisa Walz, Kristina Dietert, Helen Hoffmann, Oliver Planz, Achim D Gruber, Veronika von Messling, Thorsten Wolff
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 5, Pp 1-18 (2020)
Abstract The current seasonal inactivated influenza vaccine protects only against a narrow range of virus strains as it triggers a dominant antibody response toward the hypervariable hemagglutinin (HA) head region. The discovery of rare broadly prote
Externí odkaz:
https://doaj.org/article/83611fcf9f514407a0ffdfe7a0ffcd4f
Autor:
Beata Gromadzka, Milena Chraniuk, Lilit Hovhannisyan, Karolina Uranowska, Bogusław Szewczyk, Magdalena Narajczyk, Mirosława Panasiuk
Publikováno v:
Viruses, Vol 14, Iss 4, p 730 (2022)
(1) Background: Avian influenza viruses (AIVs) promptly evade preexisting immunity by constantly altering the immunodominant neutralizing antibody epitopes (antigenic drift) or by procuring new envelope serotypes (antigenic shift). As a consequence,
Externí odkaz:
https://doaj.org/article/4a153f4ed1774f88b4dcf14e8e5cfa6e
Publikováno v:
Expert Review of Vaccines, Vol 17, Iss 11, Pp 967-976 (2018)
Introduction: The current seasonal influenza vaccine confers only limited protection due to waning antibodies or the antigenic shift and drift of major influenza surface antigens. A universal influenza vaccine which induces broad cross-protection aga
Externí odkaz:
https://doaj.org/article/627b3f9f6bbc43cf87730c9f9f5e44d0
Autor:
Osamu Kotani, Yasushi Suzuki, Shinji Saito, Akira Ainai, Akira Ueno, Takuya Hemmi, Kaori Sano, Koshiro Tabata, Masaru Yokoyama, Tadaki Suzuki, Hideki Hasegawa, Hironori Sato
Publikováno v:
Viruses, Vol 13, Iss 9, p 1733 (2021)
The stalk domain of influenza virus envelope glycoprotein hemagglutinin (HA) constitutes the axis connecting the head and transmembrane domains, and plays pivotal roles in conformational rearrangements of HA for virus infection. Here we characterized
Externí odkaz:
https://doaj.org/article/be8f6463c0c645ff88efe235c222eb6c
Autor:
Yo Han Jang, Baik Lin Seong
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
There is an unmet public health need for a universal influenza vaccine (UIV) to provide broad and durable protection from influenza virus infections. The identification of broadly protective antibodies and cross-reactive T cells directed to influenza
Externí odkaz:
https://doaj.org/article/f67d2c00cb3744aab61ff7cd694c18d2
Autor:
Kathie-Anne Walters, Ruoqing Zhu, Michael Welge, Kelsey Scherler, Jae-Keun Park, Zainab Rahil, Hao Wang, Loretta Auvil, Colleen Bushell, Min Young Lee, David Baxter, Tyler Bristol, Luz Angela Rosas, Adriana Cervantes-Medina, Lindsay Czajkowski, Alison Han, Matthew J. Memoli, Jeffery K. Taubenberger, John C. Kash
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT In this study, we examined the relationships between anti-influenza virus serum antibody titers, clinical disease, and peripheral blood leukocyte (PBL) global gene expression during presymptomatic, acute, and convalescent illness in 83 parti
Externí odkaz:
https://doaj.org/article/f9790b867e4e4a31baa6bbf277ba8385
Autor:
Jae-Keun Park, Alison Han, Lindsay Czajkowski, Susan Reed, Rani Athota, Tyler Bristol, Luz Angela Rosas, Adriana Cervantes-Medina, Jeffery K. Taubenberger, Matthew J. Memoli
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT Influenza virus hemagglutinin (HA) surface glycoprotein is currently the primary target of licensed influenza vaccines. Recently, broadly reactive antibodies that target the stalk region of the HA have become a major focus of current novel v
Externí odkaz:
https://doaj.org/article/b0f35065638d41faa7b5bb27cae2d4b8