One HA stalk topping multiple heads as a novel influenza vaccine

Autor: Ping Zhou, Tianyi Qiu, Xiang Wang, Xi Yang, Hongyang Shi, Caihong Zhu, Weiqian Dai, Man Xing, Xiaoyan Zhang, Jianqing Xu, Dongming Zhou

Publikováno v: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

ABSTRACTClassic chimeric hemagglutinin (cHA) was designed to induce immune responses against the conserved stalk domain of HA. However, it is unclear whether combining more than one HA head domain onto one stalk domain is immunogenic and further indu

Externí odkaz: https://doaj.org/article/f270ee9be3c14a0880f00f050ad7ab5a

Immunization with extracellular vesicles conjugating inverted influenza HA elicits HA stalk-specific immunity and cross-protection in mice.

Autor: Zhu W; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA., Dong C; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA., Wei L; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA., Kim JK; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA., Wang BZ; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. Electronic address: bwang23@gsu.edu.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Dec 30. Date of Electronic Publication: 2024 Dec 30.

Layered protein nanoparticles containing influenza B HA stalk induced sustained cross-protection against viruses spanning both viral lineages

Autor: Song, Yufeng, Zhu, Wandi, Wang, Ye, Deng, Lei, Ma, Yao, Dong, Chunhong, Gonzalez, Gilbert X., Kim, Joo, Wei, Lai, Kang, Sang-Moo, Wang, Bao-Zhong

Publikováno v: In Biomaterials August 2022 287

Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBD

Autor: Yulei Li, Peipei Liu, Tianjiao Hao, Sheng Liu, Xi Wang, Yufeng Xie, Ke Xu, Wenwen Lei, Cheng Zhang, Pu Han, Ying Li, Xiyue Jin, Yu Huan, Yafei Lu, Rong Zhang, Xiaoyan Li, Xin Zhao, Kun Xu, Pu Liao, Xuancheng Lu, Yuhai Bi, Hao Song, Guizhen Wu, Baoli Zhu, George F. Gao

Publikováno v: Emerging Microbes and Infections, Vol 12, Iss 2 (2023)

Highly contagious respiratory illnesses like influenza and COVID-19 pose serious risks to public health. A two-in-one vaccine would be ideal to avoid multiple vaccinations for these diseases. Here, we generated a chimeric receptor binding domain of t

Externí odkaz: https://doaj.org/article/78b599e9f4e1408ba9f1981250f3f088

Characterization of Immune Response towards Generation of Universal Anti-HA-Stalk Antibodies after Immunization of Broiler Hens with Triple H5N1/NA-HA-M1 VLPs

Autor: Beata Gromadzka, Milena Chraniuk, Lilit Hovhannisyan, Karolina Uranowska, Bogusław Szewczyk, Magdalena Narajczyk, Mirosława Panasiuk

Publikováno v: Viruses, Vol 14, Iss 4, p 730 (2022)

(1) Background: Avian influenza viruses (AIVs) promptly evade preexisting immunity by constantly altering the immunodominant neutralizing antibody epitopes (antigenic drift) or by procuring new envelope serotypes (antigenic shift). As a consequence,

Externí odkaz: https://doaj.org/article/4a153f4ed1774f88b4dcf14e8e5cfa6e