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Quantification of spiral artery remodelling using an Adobe Photoshop-based technique

Autor: Roger F. Searle, Barbara A. Innes, Stephen C. Robson, HA Otun, Gendie E. Lash, Elizabeth Ball, B Schiessl, Judith N. Bulmer

Publikováno v: Reproduction. 158:389-397

Uterine spiral arteries undergo remodelling in normal pregnancy, with replacement of the musculoelastic arterial media by fibrinoid containing extravillous trophoblast cells. Deficient spiral artery remodelling is associated with several adverse preg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51aed150e3393c4491075e5ad3aea194
https://doi.org/10.1530/rep-19-0133

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Interferon‐γ inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels

Autor: Maureen Kirkley, Roger F. Searle, Judith N. Bulmer, Stephen C. Robson, HA Otun, Barbara A. Innes, Leandro Gustavo de Oliveira, Gendie E. Lash

Publikováno v: The FASEB Journal. 20:2512-2518

Extravillous trophoblast cell (EVT) invasion of decidua and inner third of the myometrium is critical for a successful pregnancy. Many decidual factors are likely to play a role in regulating this process, including uterine natural killer (uNK) cell-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb60c499e8d6920498b9e5ae6896982
https://doi.org/10.1096/fj.06-6616com

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Low Oxygen Concentrations Inhibit Trophoblast Cell Invasion from Early Gestation Placental Explants via Alterations in Levels of the Urokinase Plasminogen Activator System1

Autor: Roger F. Searle, Barbara A. Innes, Gendie E. Lash, HA Otun, Judith N. Bulmer, Stephen C. Robson

Publikováno v: Biology of Reproduction. 74:403-409

Extravillous trophoblast cell (EVT) invasion in early pregnancy occurs in a relatively low-oxygen environment. The role of oxygen in regulation of EVT invasion remains controversial. We hypothesized that 1) culture in 3% oxygen inhibits EVT invasion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::278592b58b16db4c9e1d4ba1196c2a5a
https://doi.org/10.1095/biolreprod.105.047332

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Inhibition of Trophoblast Cell Invasion by TGFB1, 2, and 3 Is Associated with a Decrease in Active Proteases1

Autor: Barbara A. Innes, Judith N. Bulmer, HA Otun, Roger F. Searle, Gendie E. Lash, Stephen C. Robson

Publikováno v: Biology of Reproduction. 73:374-381

Invasion of extravillous trophoblast cells into the uterus in human pregnancy is tightly regulated. The transforming growth factor-beta (TGFB) family has been suggested to play a role in controlling this process. We hypothesized that TGFB1, 2, and 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae52a2f732f9f9410e4c672527dde126
https://doi.org/10.1095/biolreprod.105.040337

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Spatial and Temporal Expression of the Myometrial Mitogen-Activated Protein Kinases p38 and ERK1/2 in the Human Uterus During Pregnancy and Labor

Autor: Jarrod Bailey, HA Otun, Stephen C. Robson, Malcolm W.J. MacDougall, G. Nicholas Europe-Finner

Publikováno v: Journal of the Society for Gynecologic Investigation. 12:185-190

We have recently identified a novel putative spliced variant of the activating transcription factor 2 (ATF2) in the human myometrium during pregnancy and labor. This protein, termed ATF2-sm like full-length ATF2, acts as a potent trans activator of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206895d0056b789f684a07b881913c75
https://doi.org/10.1016/j.jsgi.2004.11.008

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Effect of tumour necrosis factor-α in combination with interferon-γ on first trimester extravillous trophoblast invasion

Autor: Barbara A. Innes, Judith N. Bulmer, Roger F. Searle, Therese Hannon, Katsuhiko Naruse, Stephen C. Robson, HA Otun, Gendie E. Lash

Publikováno v: Journal of reproductive immunology. 88(1)

Successful pregnancy is dependent upon invasion of the uterine tissues by extravillous trophoblast cells (EVT). The mechanisms that control trophoblast invasion are unclear, but several cytokines and growth factors appear to be involved. We have prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1c01a9ef9220e524ac025321af1975
https://pubmed.ncbi.nlm.nih.gov/21112094

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Regulation of extravillous trophoblast invasion by uterine natural killer cells is dependent on gestational age

Autor: Kathryn Percival, Gendie E. Lash, Judith N. Bulmer, Roger F. Searle, Barbara A. Innes, Stephen C. Robson, HA Otun

Publikováno v: Human reproduction (Oxford, England). 25(5)

background: Extravillous trophoblast (EVT) cell invasion of uterine decidua and the inner third of myometrium is critical for successful pregnancy. Many decidual factors are likely to play a role in regulating this process. We have previously shown t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d446355975b737e0c6874659aab89477
https://pubmed.ncbi.nlm.nih.gov/20219775

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The urokinase plasminogen activator (uPA) system in uterine natural killer cells in the placental bed during early pregnancy

Autor: Barbara A. Innes, Roger Searle, Katsuhiko Naruse, HA Otun, Stephen C. Robson, Gendie E. Lash, Judith N. Bulmer

Publikováno v: Placenta. 30(5)

The urokinase plasminogen activator (uPA) system plays pivotal roles in cell invasion, adhesion and migration. Roles for uterine natural killer (uNK) cells in regulating extravillous trophoblast (EVT) invasion and spiral artery remodeling have been p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afdb40755c6de1a9e5766f588fbccf7
https://pubmed.ncbi.nlm.nih.gov/19272641

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Localization of angiogenic growth factors and their receptors in the human placental bed throughout normal human pregnancy

Autor: HA Otun, Stephen C. Robson, Judith N. Bulmer, B Schiessl, Barbara A. Innes, Thomas Chadwick, Gendie E. Lash

Publikováno v: Placenta. 30(1)

During early human pregnancy invasion of uterine spiral arteries by extravillous trophoblast cells contributes to their remodelling characterised by loss of musculo-elastic media and replacement by fibrinoid containing trophoblast. Despite its import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9c08b2d477d77e6ba2a269033ac882
https://pubmed.ncbi.nlm.nih.gov/19010534

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Comparison of three multiplex cytokine analysis systems: Luminex, SearchLight and FAST Quant

Autor: Barbara A. Innes, Roger F. Searle, Steven C. Robson, Gendie E. Lash, HA Otun, Judith N. Bulmer, Paula J. Scaife

Publikováno v: Journal of immunological methods. 309(1-2)

Multiplex cytokine analysis technologies have become readily available in the last five years. Two main formats exist: multiplex sandwich ELISA and bead based assays. While these have each been compared to individual ELISAs, there has been no direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f361625d71c06eb9628f155b16d5f9cd
https://pubmed.ncbi.nlm.nih.gov/16436279

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