Zobrazeno 1 - 10
of 60
pro vyhledávání: '"HA, haemagglutinin"'
Autor:
James G. Wood, Siranda Torvaldsen, Ann Moen, Christopher Chadwick, Erin Sparrow, Anthony T. Newall, Guido Torelli
Publikováno v:
Vaccine
Highlights • Annual seasonal vaccine production capacity is estimated at 1.48 billion doses. • Best-case annual production for pandemic vaccine is estimated at 8.31 billion doses. • Modest growth in pandemic influenza vaccine production capacit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d08d9eb8e902231bbd568075fac50e8
https://doi.org/10.1016/j.vaccine.2020.12.018
https://doi.org/10.1016/j.vaccine.2020.12.018
Autor:
Paul Gale
Publikováno v:
Microbial Risk Analysis
Highlights • Affinity of virus binding to host cell modelled as a function of temperature and number of GP/Cr contacts. • Enthalpy-driven and entropy-driven GP/Cr contacts have opposite effects on temperature sensitivity. • Model for effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b1444236eec858223f874cbdedfbb2
http://europepmc.org/articles/PMC7104215
http://europepmc.org/articles/PMC7104215
Autor:
Paul Gale
Publikováno v:
Microbial Risk Analysis
Highlights • Dose-response model for pathogen infection developed on basis of thermodynamic association constants. • Fraction of pathogen oral dose surviving mucus barrier to reach intestinal epithelium modelled. • Fraction of host intestinal e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faca9ed68b4ea8e4bf6d483b37b4c524
http://europepmc.org/articles/PMC7103988
http://europepmc.org/articles/PMC7103988
Autor:
Dengke Tian, Liang Xin, Minge Wan, Xie Xiaolin, Zhang Dezhu, Wenqiang Cao, Liang Chengyuan, Liu Yuzhi, Li Han, Hong Liu, Xueqi Fu
Publikováno v:
Biomedicine & Pharmacotherapy
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111313-(2021)
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111313-(2021)
Graphical abstract
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and re
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a760af616f0938c4e771824446939551
http://europepmc.org/articles/PMC7857046
http://europepmc.org/articles/PMC7857046
Publikováno v:
Biochemical Journal
Macrophages switch to an anti-inflammatory, ‘regulatory’-like phenotype characterized by the production of high levels of interleukin (IL)-10 and low levels of pro-inflammatory cytokines to promote the resolution of inflammation. A potential ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::582c64aa1317d6ccb69afb9b6b343395
http://europepmc.org/articles/PMC4286194
http://europepmc.org/articles/PMC4286194
Autor:
Anna Zagórska, Alan R. Prescott, Maria Deak, Dario R. Alessi, David G. Campbell, Sourav Banerjee
Publikováno v:
Biochemical Journal
NUAK1 (NUAK family SnF1-like kinase-1) and NUAK2 protein kinases are activated by the LKB1 tumour suppressor and have been implicated in regulating multiple processes such as cell survival, senescence, adhesion and polarity. In the present paper we p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb065820cbf400858132f75eb94f908c
https://doi.org/10.1042/bj20140408
https://doi.org/10.1042/bj20140408
Autor:
Natalia Shpiro, Maria Stella Ritorto, Kei Sakamoto, Dario R. Alessi, Vanessa P. Houde, Robert Gourlay, Joby Varghese, Paul Davies
Publikováno v:
Biochemical Journal
The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family of protein kinases. The highly conserved C-terminal residues of LKB1 are phosphorylated (Ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe36ddd49d60988f3b36857bd507191
https://doi.org/10.1042/bj20131324
https://doi.org/10.1042/bj20131324
Autor:
Apirat Chaikuad, Tracy Keates, Cécile Vincke, Melanie Kaufholz, Michael Zenn, Zimmermann Bastian, Carlos Gutiérrez, Rong-Guang Zhang, Catherine Hatzos-Skintges, Andrzej Joachimiak, Serge Muyldermans, Herberg, Friederich W., Knapp, S., Muller, S.
Publikováno v:
Biochemical Journal; Vol 459
Vrije Universiteit Brussel
Biochemical Journal
Vrije Universiteit Brussel
Biochemical Journal
GAK (cyclin G-associated kinase) is a key regulator of clathrin-coated vesicle trafficking and plays a central role during development. Additionally, due to the unusually high plasticity of its catalytic domain, it is a frequent ‘off-target’ of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::28494c44a0dbcb3f60d6899956ca5071
Autor:
Jinhua Wang, Alan R. Prescott, Nathanael S. Gray, Ryan Traynor, Hai-Tsang Huang, Sourav Banerjee, Sara J. Buhrlage, Xianming Deng, Wenjun Zhou, Dario R. Alessi
Publikováno v:
Biochemical Journal
The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated by the LKB1 (liver kinase B1) tumour suppressor kinase. Recent work suggests they play important roles in regulating key b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d07d9ac0f6f4c4a17a25a75be92725
https://doi.org/10.1042/bj20131152
https://doi.org/10.1042/bj20131152
Publikováno v:
Biochemical Journal
It is believed that the stability and activity of client proteins are passively regulated by the Hsp90 (heat-shock protein 90) chaperone machinery, which is known to be modulated by its intrinsic ATPase activity, co-chaperones and post-translational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88b97470e2c988f9a9339b83cd39488
https://doi.org/10.1042/bj20130963
https://doi.org/10.1042/bj20130963