Sialic acid O-acetylation: From biosynthesis to roles in health and disease

Autor: Thomas J. Boltje, Heleen de Jong, Sam J. Moons, Eline A. Visser, Suzanne B. P. E. Timmermans, Christian Büll

Publikováno v: The Journal of Biological Chemistry
Journal of Biological Chemistry, 297, 1-19
Journal of Biological Chemistry, 297, 2, pp. 1-19
Visser, E A, Moons, S J, Timmermans, S B P E, de Jong, H, Boltje, T J & Büll, C 2021, ' Sialic acid O-acetylation : From biosynthesis to roles in health and disease ', Journal of Biological Chemistry, vol. 297, no. 2, 100906, pp. 1-19 . https://doi.org/10.1016/j.jbc.2021.100906

Sialic acids are nine-carbon sugars that frequently cap glycans at the cell surface in cells of vertebrates as well as cells of certain types of invertebrates and bacteria. The nine-carbon backbone of sialic acids can undergo extensive enzymatic modi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704561863100cd1be53c62370b397510
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/245797

PERK Inhibition Mitigates Restenosis and Thrombosis

Autor: Yitao Huang, Shahid M Nimjee, Go Urabe, Debra G Wheeler, David J. Dornbos, Bowen Wang, Allyson Huttinger, Guojun Chen, Mengxue Zhang, Lian-Wang Guo, K. Craig Kent, Shaoqin Gong

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • Drug-eluting stents impede neointimal smooth muscle cell hyperplasia but exacerbate endothelial cell dysfunction and thrombogenicity. It has been a challenge to identify a common target to inhibit both. Findings in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687fd944746d5484e3fd724b4e1ee496
https://doi.org/10.1016/j.jacbts.2019.12.005

Rapid inactivation of the yeast Sec complex selectively blocks transport of post-translationally translocated proteins

Autor: Reid Gilmore, Jae Kyo Yi, Hidenobu Fujita, Elisabet C. Mandon

Publikováno v: The Journal of Biological Chemistry

The yeast endoplasmic reticulum has three distinct protein translocation channels. The heterotrimeric Sec61 and Ssh1 complexes, which bind translating ribosomes, mediate cotranslational translocation of proteins targeted to the endoplasmic reticulum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810aa777fb72075206ecf2186fe3f8c6
http://europepmc.org/articles/PMC8503631

The HIV-1 accessory protein Nef increases surface expression of the checkpoint receptor Tim-3 in infected CD4+ T cells

Autor: Jimmy D. Dikeakos, Cassandra R Edgar, Andrés Finzi, S. M. Mansour Haeryfar, Alexa Galbraith, Jérémie Prévost, Mitchell J. Mumby, Rajesh Abraham Jacob, Frank Kirchhoff, Antony Lurie, Steven M. Trothen

Publikováno v: The Journal of Biological Chemistry

Prolonged immune activation drives the upregulation of multiple checkpoint receptors on the surface of virus-specific T cells, inducing their exhaustion. Reversing HIV-1-induced T cell exhaustion is imperative for efficient virus clearance; however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4498fbba12fc0bc9e4265261297f405
http://europepmc.org/articles/PMC8390549

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate CellsSummary

Autor: Romil Saxena, Wenjie Cai, Yang Zhang, Menghao Huang, Xiaolin Zhong, Kushan Chowdhury, Robert F. Schwabe, Suthat Liangpunsakul, Hyeong-Geug Kim, X. Charlie Dong

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 341-364 (2020)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that is manifested clinically by an increase in hepatic triglycerides, inflammation, and fibrosis. The pathogenesis of NASH remains incompletely understood. Sirtuin 6 (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e993c50fadc362faaa1fba27859fd85
http://www.sciencedirect.com/science/article/pii/S2352345X20300497