Zobrazeno 1 - 2
of 2
pro vyhledávání: '"H3K9, histone H3 Lys9"'
Autor:
Christin L. Hanigan, Patrick M. Woster, Lihua Jin, Yu-Yu Wu, Ben Ho Park, Robert A. Casero, Wei-wei Wang
Publikováno v:
Biochemical Journal
Epigenetic silencing of gene expression is important in cancer. Aberrant DNA CpG island hypermethylation and histone modifications are involved in the aberrant silencing of tumour-suppressor genes. LSD1 (lysine-specific demethylase 1) is a H3K4 (hist
Publikováno v:
Clinical Science (London, England : 1979)
Sirtuins are members of the Sir2 (silent information regulator 2) family, a group of class III deacetylases. Mammals have seven different sirtuins, SIRT1–SIRT7. Among them, SIRT1, SIRT3 and SIRT6 are induced by calorie restriction conditions and ar