Zobrazeno 1 - 10
of 651
pro vyhledávání: '"H3K27Ac"'
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background iPSC reprogramming technology exhibits significant promise in the realms of clinical therapeutics, disease modeling, pharmaceutical drug discovery, and various other applications. However, the extensive utilization of this technol
Externí odkaz:
https://doaj.org/article/741d377c95c5444086207e38024cbde8
Autor:
Yi Wang, Shuwen Chen, Min Xue, Jinhu Ma, Xinrui Yi, Xinyu Li, Xuejin Lu, Meizi Zhu, Jin Peng, Yunshu Tang, Yaling Zhu
Publikováno v:
Animal Bioscience, Vol 37, Iss 8, Pp 1317-1332 (2024)
Objective Rare study of the non-coding and regulatory regions of the genome limits our ability to decode the mechanisms of fatty liver hemorrhage syndrome (FLHS) in chickens. Methods Herein, we constructed the high-fat diet-induced FLHS chicken model
Externí odkaz:
https://doaj.org/article/ed39f2ac5f104c6b93c7b5e5225f148b
Autor:
Leonor Schubert Santana, Alejandro Reyes, Sebastian Hoersch, Enrico Ferrero, Christian Kolter, Swann Gaulis, Sebastian Steinhauser
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2190-2199 (2024)
Spatiotemporal regulation of gene expression is controlled by transcription factor (TF) binding to regulatory elements, resulting in a plethora of cell types and cell states from the same genetic information. Due to the importance of regulatory eleme
Externí odkaz:
https://doaj.org/article/b389b0582e8748f19a3f095d7b02a90d
Autor:
Yu Hong, Xinlan Li, Jia Li, Qiuyi He, Manbing Huang, Yubo Tang, Xiao Chen, Jie Chen, Ke-Jing Tang, Chao Wei
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Doxorubicin (Dox) is an effective chemotherapeutic drug for various cancers, but its clinical application is limited by severe cardiotoxicity. Dox treatment can transcriptionally activate multiple cardiotoxicity-associated genes i
Externí odkaz:
https://doaj.org/article/c4132cbacef7408a885444a562b86064
Publikováno v:
陆军军医大学学报, Vol 46, Iss 7, Pp 695-704 (2024)
Objective To explore the genome-wide distribution of histone H3K27ac in intestinal type gastric cancer, analyze remodeling features of enhancers and regulome and construct a prediction model for prognosis. Methods H3K27ac CUT&Tag sequencing and RNA s
Externí odkaz:
https://doaj.org/article/86bb7726dc6f4da99391dc5db10c10d7
Autor:
Yanli Liu, Zhuqing Zheng, Chaohui Wang, Yumeng Wang, Xi Sun, Zhouzheng Ren, Xin Yang, Xiaojun Yang
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Fatty liver disease causes huge economic losses in the poultry industry due to its high occurrence and lethality rate. Three-dimensional (3D) chromatin architecture takes part in disease processing by regulating transcriptional re
Externí odkaz:
https://doaj.org/article/6d04ce502b264b3d9340bbe64eb2e355
Autor:
Xiaomei Wan, Jianwei Wang, Fang Fang, Yixin Hu, Zimu Zhang, Yanfang Tao, Yongping Zhang, Juanjuan Yu, Yumeng Wu, Bi Zhou, Hongli Yin, Li Ma, Xiaolu Li, Ran Zhuo, Wei Cheng, Shuqi Zhang, Jian Pan, Jun Lu, Shaoyan Hu
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Acute myeloid leukemia (AML) is a malignancy of the hematopoietic system, and childhood AML accounts for about 20% of pediatric leukemia. ANP32B, an important nuclear protein associated with proliferation, has been found to regula
Externí odkaz:
https://doaj.org/article/e2c5e36adc2445058dac87a21df6581d
Autor:
Xin Guan, Ruiqi Liu, Bojun Wang, Ruxin Xiong, Luying Cui, Yuanyu Liao, Yuli Ruan, Lin Fang, Xiaolin Lu, Xuefan Yu, Dan Su, Yue Ma, Tianjiao Dang, Zhuo Chen, Yuanfei Yao, Chao Liu, Yanqiao Zhang
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Background Although numerous studies have indicated that activated pyroptosis can enhance the efficacy of antitumour therapy in several tumours, the precise mechanism of pyroptosis in colorectal cancer (CRC) remains unclear. Methods Pyroptos
Externí odkaz:
https://doaj.org/article/6beb11d974954c529a23288c5ac51a03
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/ccaf568071ef4488a5320800fb7b7769
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Enhancers play a crucial role in gene regulation, and some active enhancers produce noncoding RNAs known as enhancer RNAs (eRNAs) bi-directionally. The most commonly used method for detecting eRNAs is CAGE-seq, but the instability
Externí odkaz:
https://doaj.org/article/631f9d57332943e2a374f647e39cd215