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A Useful Role for 'Static' Models in Elucidating the Behaviour of DNA in Solution

Autor: H.R. Drew, C. R. Calladine

Publikováno v: Journal of Molecular Biology. 257:479-485

Double-helical DNA is a long and flexible molecule that is in constant motion under thermal perturbations, more so in solution than in the crystal. Some workers, for example Olsen et al. , have argued that the behaviour of this molecule in assays suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb0e6dfd232c7f7fe8f3bdaa18cb800
https://doi.org/10.1006/jmbi.1996.0177

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High mobility group proteins 14 and 17 can space nucleosomes in vitro

Autor: H.R. Drew, David J. Tremethick

Publikováno v: Journal of Biological Chemistry. 268:11389-11393

Recently we partially purified from Xenopus laevis ovaries a novel, ATP-dependent, spacing activity that can convert a DNA template consisting of irregularly spaced nucleosomes into a chromatin structure made up of regularly spaced nucleosomes with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf1831f7564dfa34b26f1df1a12fdb96
https://doi.org/10.1016/s0021-9258(18)82136-6

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Reversible bending and helix geometry in a B-DNA dodecamer: CGCGAATTBrCGCG

Autor: Mary L. Kopka, H.R. Drew, A V Fratini, Richard E. Dickerson

Publikováno v: Journal of Biological Chemistry. 257:14686-14707

A double-helical B-DNA dodecamer has been analyzed by single crystal x-ray diffraction methods and refined independently in four variants: sequence CGCGAATTCGCG at 20 degrees C and at 16 K, and CGCGAATTBrCGCG in 60% methylpentanediol at 20 and at 7 d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11efa1c1f42738eb06ef007b1231f574
https://doi.org/10.1016/s0021-9258(18)33335-0

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Akademický článek

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Echinomycin and distamycin induce rotation of nucleosome core DNA

Autor: C.M.L. Low, M.J. Waring, H.R. Drew

When nucleosome cores reconstituted from chicken erythrocyte histones and a 160 bp DNA molecule are exposed to echinomycin, a bis-intercalating antitumour antibiotic, the DNA appears to rotate with respect to the histone octamer by about half a turn.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7b298638ae43c6dccfe14adc1de650
https://europepmc.org/articles/PMC311699/

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Negative supercoiling induces spontaneous unwinding of a bacterial promoter

Autor: H.R. Drew, Andrew Travers, J.R. Weeks

Publikováno v: The EMBO journal. 4(4)

We have examined the influence of negative supercoiling on the DNA structure of a bacterial promoter (tyrT from Escherichia coli), the transcriptional activity of which is strongly enhanced by torsional stress in vitro. Certain regions of this promot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c2ffdee9ea498805f88e08b5352590
https://pubmed.ncbi.nlm.nih.gov/2990904

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A new model for DNA containing A.T and I.C base pairs

Autor: H.R. Drew, R.E. Dickerson

Publikováno v: The EMBO journal. 1(6)

DNA polymers containing exclusively A.T or I.C base pairs frequently exhibit D- or E-type X-ray diffraction patterns when dried. The distribution of intensities in fiber patterns appears to demand helical structures with 7 and 7.5 bp/turn, respective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0354bd83740c4d0877f60fe146ca22
https://pubmed.ncbi.nlm.nih.gov/7188355

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Helix geometry and hydration in A-DNA, B-DNA, and Z-DNA

Autor: B.N. Conner, M.L. Kopka, R.E. Dickerson, H.R. Drew, P.E. Pjura

Publikováno v: Cold Spring Harbor symposia on quantitative biology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13f0ab8f92737e23ffa3f2a049f6c5b
https://pubmed.ncbi.nlm.nih.gov/6574838

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The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G

Autor: R.M. Wing, H.R. Drew, Richard E. Dickerson, P.E. Pjura

Publikováno v: The EMBO journal. 3(5)

When cisplatin [cis- diamminodichloroplatinum (II)] is diffused into pre-grown crystals of the B-DNA double-helical dodecamer C-G-C-G-A-A-T-T-C-G-C-G, it binds preferentially to the N7 positions of guanines, with what probably is an aquo bridge betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd50dd992d6d9dd9dfb631c137c1582
https://pubmed.ncbi.nlm.nih.gov/6539674

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