81: PHARMACOKINETICS/PHARMACODYNAMICS OF ANTI-PSEUDOMONAL PHAGE: LEVERAGING PRECLINCAL MODELS OF INFECTION AND MECHANISM-BASED MODELLING

Autor: S.C. Nang, Y.W. Lin, P. Hanafin, J. Wang, K. Chen, H.H. Yu, H. Wickremasinghe, P.J. Bergen, R.Y.K. Chang, G. Rao, H.K. Chan, J. Li

Publikováno v: Journal of Global Antimicrobial Resistance, Vol 31, Iss , Pp S48-S50 (2022)

Externí odkaz: https://doaj.org/article/d26cd78f21af4cd6923c5d6e74d033ec

T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity

Autor: Conor M. Finlay, James E. Parkinson, Lili Zhang, Brian H.K. Chan, Jesuthas Ajendra, Alistair Chenery, Anya Morrison, Irem Kaymak, Emma L. Houlder, Syed Murtuza Baker, Ben R. Dickie, Louis Boon, Joanne E. Konkel, Matthew R. Hepworth, Andrew S. MacDonald, Gwendalyn J. Randolph, Dominik Rückerl, Judith E. Allen

Publikováno v: Finlay, C M, Parkinson, J E, Zhang, L, Chan, B H K, Ajendra, J, Chenery, A, Morrison, A, Kaymak, I, Houlder, E L, Murtuza baker, S, Dickie, B R, Boon, L, Konkel, J E, Hepworth, M R, Macdonald, A S, Randolph, G J, Rückerl, D & Allen, J E 2023, ' T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity ', Immunity, vol. 56, pp. 1–18.e1–e10 . https://doi.org/10.1016/j.immuni.2023.02.016
Finlay, C M, Parkinson, J E, Zhang, L, Chan, B H K, Ajendra, J, Chenery, A, Morrison, A, Kaymak, I, Houlder, E L, Murtuza Baker, S, Dickie, B R, Boon, L, Konkel, J E, Hepworth, M R, MacDonald, A S, Randolph, G J, Rückerl, D & Allen, J E 2023, ' T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity ', Immunity . https://doi.org/10.1016/j.immuni.2023.02.016

The recent revolution in tissue-resident macrophage biology has resulted largely from murine studies performed in C57BL/6 mice. Here, using both C57BL/6 and BALB/c mice, we analyze immune cells in the pleural cavity. Unlike C57BL/6 mice, naive tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d230903b3f29ce1b28466fde5aeb5380
https://hdl.handle.net/20.500.11820/6377fd26-84f2-41a6-8c7a-7030a6d58793

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Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner

Autor: Pedro H. Papotto, Bahtiyar Yilmaz, Gonçalo Pimenta, Sofia Mensurado, Carolina Cunha, Gina J. Fiala, Daniel Gomes da Costa, Natacha Gonçalves-Sousa, Brian H.K. Chan, Birte Blankenhaus, Rita G. Domingues, Tânia Carvalho, Matthew R. Hepworth, Andrew J. Macpherson, Judith E. Allen, Bruno Silva-Santos

Publikováno v: Papotto, Pedro H; Yilmaz, Bahtiyar; Pimenta, Gonçalo; Mensurado, Sofia; Cunha, Carolina; Fiala, Gina J; Gomes da Costa, Daniel; Gonçalves-Sousa, Natacha; Chan, Brian H K; Blankenhaus, Birte; Domingues, Rita G; Carvalho, Tânia; Hepworth, Matthew R; Macpherson, Andrew J; Allen, Judith E; Silva-Santos, Bruno (2023). Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner. (In Press). Cell reports(112074), p. 112074. Cell Press 10.1016/j.celrep.2023.112074

Immune development is profoundly influenced by vertically transferred cues. However, little is known about how maternal innate-like lymphocytes regulate offspring immunity. Here, we show that mice born from γδ T cell-deficient (TCRδ-/-) dams displ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb309f2e5b0b74e2cec3d13af01851a9
https://boris.unibe.ch/178823/1/1-s2.0-S2211124723000852-main.pdf

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