Zobrazeno 1 - 10
of 45
pro vyhledávání: '"H.J.G.M. Derks"'
Publikováno v:
Chemosphere. 28:711-715
A physiologically based pharmacokinetic (PB-PK) model for 2,3,7,8-TCDD in cows is described. Uptake in tissues appears to be blood flow limited except in adipose. Sensitive model parameters are fat tissue volume and bioavailability. The agreement bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d49cb9b10c211f637302714b7e95362
https://doi.org/10.1016/0045-6535(94)90222-4
https://doi.org/10.1016/0045-6535(94)90222-4
Autor:
D. P. K. H. Pereboom-De Fauw, K. Groen, P. Besamusca, G. J. A. Speijers, P. K. Beekhof, H.J.G.M. Derks
Publikováno v:
Xenobiotica. 23:995-1005
1. The toxicokinetics of [3H]-α-solanine after oral (p.o.) and intravenous (i.v.) administration in rat and hamster were studied, in order to decide which is the most appropriate model in risk assessment studies. The i.v. Dose was 54 βg/kg; the ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93585d0b80f20bead8060043079c1e08
https://doi.org/10.3109/00498259309057038
https://doi.org/10.3109/00498259309057038
Publikováno v:
Chemosphere. 23:1377-1385
Eight 13 C-labelled PCDD's and PCDF's dissolved in olive oil were administered intraruminally to four lactating cows as a single dose. Milk and body fat concentrations were monitored for 93 days. Mean elimination half lifes of most congeners varied f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::446bfaf6ce5769ace6995eb01abd0657
https://doi.org/10.1016/0045-6535(91)90162-7
https://doi.org/10.1016/0045-6535(91)90162-7
Publikováno v:
Chemosphere. 31(8)
To estimate congener-specific bioavailabilities for 17 PCDD/Fs in cows grazing near a MSW incinerator both a controlled lab study and a field study were performed: In the lab study the estimates were derived from the elevated concentrations in milk f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67455e237f2d44621e79bb6da2f1eb7
https://pubmed.ncbi.nlm.nih.gov/7583023
https://pubmed.ncbi.nlm.nih.gov/7583023
Publikováno v:
International Journal of Biochemistry. 17:839-842
1. 1. Intraperitoneal injection of the phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (IBMX), resulted in a rapid and transient induction of rat hepatic ornithine decarboxylase (ODC) activity. Maximal activity was found about 5 hr after app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef7ac408b13b03c028ade6e6c1302bd
https://doi.org/10.1016/0020-711x(85)90274-5
https://doi.org/10.1016/0020-711x(85)90274-5
Publikováno v:
Journal of Chromatography A. 370:173-178
An improved method for the determination of 6-acetylmorphine in the urine of drug addicts receiving morphine was developed. A newly introduced reversed-phase high-performance liquid chromatographic system proved to be more sensitive than a normal-pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0657c06dd65229c25efbc1516768d072
https://doi.org/10.1016/s0021-9673(00)94686-7
https://doi.org/10.1016/s0021-9673(00)94686-7
Publikováno v:
Analytical Biochemistry. 73:391-396
A simple and inexpensive technique for the monitoring of radioactive compounds in gas chromatographic effluent is described. Use has been made of the adsorption properties of thin layer chromatography plates to trap eluting radioactive peaks. Perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff226debc5ab91da46e6819880b7bbe
https://doi.org/10.1016/0003-2697(76)90185-8
https://doi.org/10.1016/0003-2697(76)90185-8
Publikováno v:
Carcinogenesis. 5:225-229
A single i.p. injection of 12-O-tetradecanoylphorbol-13-acetate (TPA) induced a transient increase in the levels of rat liver putrescine, spermidine and spermine. These polyamine concentrations continuously increased until 6 h, immediately following
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31548c2b7b5fea395179447bd13d7ec3
https://doi.org/10.1093/carcin/5.2.225
https://doi.org/10.1093/carcin/5.2.225
Publikováno v:
Analytica Chimica Acta. 170:13-20
A sensitive method is described for the determination of 6-acetylmorphine in urine, to detect the use of heroin by drug addicts participating in a morphine-dispensing experiment. The method is based on an extraction procedure, reaction of the isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5be822e93a8d154ef7f4b450728a32f
https://doi.org/10.1016/s0003-2670(00)81721-3
https://doi.org/10.1016/s0003-2670(00)81721-3
Publikováno v:
Human Toxicology. 3:7-21
1 Urine was collected from 289 inhabitants of a cadmium-polluted quarter of Stadskanaal. The excretion of cadmium, protein, beta-2-microglobulin and glucose were determined. After being divided according to sex and to smoking habits, the results of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbf67e7191d778f85ff378eb50922f5
https://doi.org/10.1177/0960327184003001021
https://doi.org/10.1177/0960327184003001021