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pro vyhledávání: '"H.J. van Kranen"'
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Autor:
H. van Steeg, C. F. Van Kreijl, Peter J.A. Capel, Anja Westerman, P. W. Wester, F.R. de Gruijl, R. J. W. Berg, Susan W.P. Wijnhoven, H.J. van Kranen, A. De Vries
Publikováno v:
Oncogene. 16:2205-2212
Xeroderma pigmentosum (XP) patients with a defect in the nucleotide excision repair gene XPA, develop tumors with a high frequency on sun-exposed areas of the skin. Here we describe that hairless XPA-deficient mice also develop skin tumors with a sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84b41054983eb9ad8a278a28e75350e
https://doi.org/10.1038/sj.onc.1201744
https://doi.org/10.1038/sj.onc.1201744
Autor:
R. J. W. Berg, A. De Vries, F.R. de Gruijl, C. F. Van Kreijl, Nicolas Dumaz, P. W. Wester, H.J. van Kranen, Leela Daya-Grosjean, Alain Sarasin
Publikováno v:
Carcinogenesis. 18:897-904
Mutation spectra of the p53 gene from human skin carcin- process that involves many modifications including proto-omas have been connected to solar UV radiation. For oncogenes and tumor suppressor genes. Among these, the p53comparison we have charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac77eacf71fd3429dcd14b1a3c251659
https://doi.org/10.1093/carcin/18.5.897
https://doi.org/10.1093/carcin/18.5.897
Autor:
KhanPM, J.H.J.M. van Krieken, Cor Breukel, Riccardo Fodde, Alex Kartheuser, S L Williamson, Shantie Jagmohan-Changur, Ron Smits, Winfried Edelmann, H.J. van Kranen, A. De Vries, V Leblanc, Raju Kucherlapati
Publikováno v:
Carcinogenesis, 18(2), 321-327. Oxford University Press
The Apc1638N mouse carries a targeted mutant allele at the endogenous adenomatous polyposis coli (Apc) gene and represents a unique in vivo model to study intestinal tumor formation and progression. Heterozygous Apc+/Apc1638N mice progressively devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87772a0b021b757b1ca4930e844de9bf
https://pure.eur.nl/en/publications/9931e2e4-6255-4ff6-bd5d-9755c7521d1c
https://pure.eur.nl/en/publications/9931e2e4-6255-4ff6-bd5d-9755c7521d1c
Autor:
A. De Vries, H.J. van Kranen, H. C. M. Senden, F.R. de Gruijl, Y. Sontag, E. Rozemuller, C. F. Van Kreijl, P. W. Wester
Publikováno v:
Carcinogenesis. 16:1141-1147
We have investigated UV-B-induced skin tumors of hairless SKH-HRA mice for alterations in the p53 gene and for mutations in either of the three ras genes. Out of 32 tumors screened, only one contained a ras mutation, i.e. in codon 12 of the K-ras gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40a0481c53c9957f507c68783f5459b
https://doi.org/10.1093/carcin/16.5.1141
https://doi.org/10.1093/carcin/16.5.1141
Autor:
A. El Ghalbzouri, Pieter Voskamp, H.J. van Kranen, Heggert Rebel, Carolien A. Bodmann, Gudrun E. Koehl, Cornelis P. Tensen, Edward K. Geissler, F.R. de Gruijl, Rein Willemze, J.N. Bouwes Bavinck
Publikováno v:
International Journal of Cancer, 131(6), 1267-76
Because of its antitumor effect, the immunosuppressant rapamycin holds great promise for organ transplant recipients in that it may lower their cancer risk. In a mouse model, we showed previously that rapamycin inhibits the outgrowth of primary skin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991092ab36dd6c5f2d247a65e056891a
https://doi.org/10.1002/ijc.27391
https://doi.org/10.1002/ijc.27391
Autor:
P. Faessen, H. van Steeg, P.W.C. van Iersel, H.J. van Kranen, L. Schoren, A. De Vries, d C.F. van Kreijl
Publikováno v:
Carcinogenesis. 15:307-311
The PCR technique in combination with selective hybridization to mutation specific oligonucleotides, is a widely used methodology for the detection of activating point mutations in ras oncogenes. In the present paper we demonstrate for the N-ras gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f387cae24996122c9943c035ec4643
https://doi.org/10.1093/carcin/15.2.307
https://doi.org/10.1093/carcin/15.2.307
Autor:
B. Hoebee, J.M. de Stoppelaar, R.F. Suijkerbuijk, Georges R. Mohn, H.J. van Kranen, P. Faessen
Publikováno v:
Cytogenetic and Genome Research. 67:23-26
The rat N-rαs protooncogene has been assigned to chromosome 2q34 by fluorescence in situ hybridization on rat metaphase chromosomes. This was accomplished using two recently isolated genomic clones with a length of 8.2 and 4.1 kb.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b583eed6d4eb0286d20c48afd8f55e44
https://doi.org/10.1159/000133718
https://doi.org/10.1159/000133718
Autor:
P.W.C. van Iersel, L. Schoren, C.F. van Kreiji, Ruud Woutersen, E. Vermeulen, E. Scherer, J. Bax, H.J. van Kranen
Publikováno v:
Carcinogenesis. 12:1477-1482
We have investigated the presence of mutations in ras genes at codons 12, 13 and 61 in chemically induced pancreatic tumors of rats and Syrian hamsters. Mutations were detected by means of allele-specific oligonucleotide hybridization to ras sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da658c1562d5078d50b2f8ab737345e4
https://doi.org/10.1093/carcin/12.8.1477
https://doi.org/10.1093/carcin/12.8.1477
Publikováno v:
Carcinogenesis, 19, 1697-1601
Carcinogenesis 19 (1998)
Carcinogenesis 19 (1998)
The variation in colorectal cancer (CRC) incidence worldwide strongly suggests a role for dietary influences. Based on epidemiological data, protective effects of vegetables and fruit intake on CRC are widely claimed, while other data indicate a poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6b33f6f2faa41f06630d4cba94e98f
https://research.wur.nl/en/publications/effects-of-dietary-fat-and-a-vegetable-fruit-mixture-on-the-devel
https://research.wur.nl/en/publications/effects-of-dietary-fat-and-a-vegetable-fruit-mixture-on-the-devel