Zobrazeno 1 - 10
of 64
pro vyhledávání: '"H.J. Winkens"'
Autor:
Hans-Hilger Ropers, Victor Alamo-Bethencourt, H.J. Winkens, Frans P.M. Cremers, José A. J. M. van den Hurk, Wei Shi, Wolfgang Mayer, Reinald Fundele
Publikováno v:
Developmental Biology, 272, 1, pp. 53-65
Developmental Biology, 272, 53-65
Developmental Biology, 272, 53-65
Contains fulltext : 59117.pdf (Publisher’s version ) (Closed access) Choroideremia (CHM) is a hereditary eye disease caused by mutations in the X-linked CHM gene. Disruption of the Chm gene in mice resulted in prenatal death of Chm-/Y males and Chm
Publikováno v:
Vision Research, 43, 28, pp. 3075-9
Vision Research, 43, 3075-9
Vision Research, 43, 3075-9
Item does not contain fulltext In addition to RDH5, other enzymes capable of oxidizing 11-cis-retinol are present within the retinal pigment epithelium, Muller cells and/or photoreceptors. Candidate proteins have meanwhile been identified. To study t
Autor:
Alfred J. L. G. Pinckers, J.J.M. Janssen, H.J. Winkens, August F. Deutman, B. P. M. Janssen, C.A.G.G. Driessen, Anke H. M. Van Vugt, Leonoor D. Kuhlmann
Publikováno v:
Ophthalmology. 108:1479-1484
Purpose Recent studies show that mutations in the gene encoding 11- cis retinol dehydrogenase are associated with fundus albipunctatus. The authors wanted to investigate whether additional, more severe, mutations in the 11- cis retinol dehydrogenase
Autor:
A.H.M. van Vugt, B. P. M. Janssen, E.D. Kuhlmann, C.A.G.G. Driessen, August F. Deutman, J.J.M. Janssen, H.J. Winkens
Publikováno v:
NeuroReport. 11:1565-1569
The effect of retinoic acid on the differentiation of a human retinal pigment epithelium-derived cell line ARPE-19 was studied. Differentiation of ARPE-19 cells is delayed by retinoic acid. The minimum all-trans-retinoic acid concentration needed for
Autor:
H.J. Winkens, C.A.G.G. Driessen, August F. Deutman, A.P.M. Janssen, A.H.M. van Vugt, J.J.M. Janssen, E.D. Kuhlmann
Publikováno v:
Current Eye Research, 19, pp. 338-347
Current Eye Research, 19, 338-347
Current Eye Research, 19, 338-347
In the mature retina retinoic acid (RA) biosynthesis was reported to be regulated by light. RA is of vital importance for proper function of the retina. RA activity is mediated by interaction with nuclear retinoic acid receptors (RARs) and retinoid X
Publikováno v:
Experimental Eye Research. 56:575-583
The pathogenicity of uveal tissue and melanin has been a controversial subject for a long time. The present new approach has elucidated some of the problems. Melanin granules have been extracted from bovine choroid, iris, hair and skin, and from huma
Publikováno v:
Experimental Eye Research. 55:819-829
Purified retinal pigment epithelial cells of bovine eyes have been fractionated by a series of buffer and detergent extractions. The electropherogram of the buffer-insoluble, Triton X-100-soluble fraction (RPE-TS) exhibits a major polypeptide band of
Publikováno v:
Experimental Eye Research. 55:401-411
Retinal pigment epithelial cell fractions have been investigated for their capacity to induce experimental uveitis. Cells of the dark (melanotic) and light areas of the bovine RPE have subsequently been extracted by buffer, Triton X-100, sodium dodec
Publikováno v:
Experimental Eye Research. 52:465-474
The uveitogenicity of several protein fractions of the bovine retinal pigment epithelium (RPE) was studied in Lewis rats, and a major pathogenic fraction was selected. Fresh RPE cells were carefully isolated and purified in order to minimize the pres
Autor:
H.J. Winkens, Wolfgang Baehr, C.A.G.G. Driessen, Akiko Maeda, Wenyu Sun, Krzysztof Palczewski, Beata Jastrzebska, Tadao Maeda, Yoshikazu Imanishi, Denise A. Hatala, Klaus Peter Hofmann, J.J.M. Janssen
Publikováno v:
Journal of Biological Chemistry, 281, 37697-704
Journal of Biological Chemistry, 281, 49, pp. 37697-704
Journal of Biological Chemistry, 281, 49, pp. 37697-704
Contains fulltext : 50335.pdf (Publisher’s version ) (Open Access) RDH12 has been suggested to be one of the retinol dehydrogenases (RDH) involved in the vitamin A recycling system (visual cycle) in the eye. Loss of function mutations in the RDH12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f12dd1886feef8dd07ec5f589e0c713
http://hdl.handle.net/2066/50335
http://hdl.handle.net/2066/50335