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The Low-Cost, Semi-Automated Shifter Microscope Stage Transforms Speed and Robustness of Manual Protein Crystal Harvesting

Autor: M Ye, F. von Delft, N D Wright, E.R. Nelson, H.J. Wiggers, N Mitrovich, P.M. Collins, J.A. Newman, R. Talon, Radosław P. Nowak, J. Ng, L. Koekemoer

Despite the tremendous success of x-ray cryocrystallography over recent decades, the transfer of crystals from the drops where they grow to diffractometer sample mounts, remains a manual process in almost all laboratories. Here we describe the Shifte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e0ffbb491ba6555e8ac2c1000dc273
https://doi.org/10.1101/2019.12.20.875674

Identification of Anti-Inflammatory and Anti-Hypertensive Drugs as Inhibitors of Bacterial Diguanylate Cyclases

Autor: Marcos V.A.S. Navarro, Éverton E. D. Silva, H.J. Wiggers, N. U. Torres, Juliana Cheleski, Edson Crusca

Publikováno v: Journal of the Brazilian Chemical Society v.29 n.2 2018
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Biofilms are widely present in many human chronic infections, often more resistant to treatment with antibiotics. Bacterial diguanylate cyclases (DGCs) synthesize cyclic dimeric guanosine monophosphate (c-di-GMP) from two guanosine-5'-triphosphate (G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadb86e7e96cf3834ce7a4a529369b38
https://doi.org/10.21577/0103-5053.20170141

Structural and thermodynamic studies of two centrin isoforms from Blastocladiella emersonii upon calcium binding

Autor: Ana Paula Ulian de Araújo, Julio C.P. Damalio, Paulo César de Camargo, H.J. Wiggers, Karina Fabiana Ribichich, Ana I. Camargo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Centrins are calcium-binding proteins associated with microtubules organizing centers. Members of two divergent subfamilies of centrins were found in the aquatic fungus Blastocladiella emersonii, contrasting with the occurrence of only one member kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755a6ed8297f89fbdeb9f34a87b9a396
https://doi.org/10.1016/j.bbapap.2013.10.007

Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: Implications to tetramer stability and ligand-binding

Autor: Carlos A. Montanari, Leonardo C. Palmieri, Igor Polikarpov, H.J. Wiggers, Luís Maurício T.R. Lima, Debora Foguel, Daniela B. B. Trivella, Lucas Bleicher, Jeffery W. Kelly

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Transthyretin (TTR) is a tetrameric β-sheet-rich transporter protein directly involved in human amyloid diseases. It was recently found that the isoflavone genistein (GEN) potently inhibits TTR amyloid fibril formation ( Green et al., 2005 ) and is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2064033b4e51109439a05c941d48a8
https://doi.org/10.1016/j.jsb.2010.03.002