Zobrazeno 1 - 10
of 42
pro vyhledávání: '"H.G. Koebe"'
Publikováno v:
Artificial Organs. 20:1181-1190
Two hypothermic preservation techniques were investigated to assess their possible role in on-demand cell supply for bioartificial liver support devices. Porcine hepatocytes from slaughterhouse organs were isolated and either cold stored in a modifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb434f31e978ad001b0f75ad75e79dd
https://doi.org/10.1111/j.1525-1594.1996.tb00659.x
https://doi.org/10.1111/j.1525-1594.1996.tb00659.x
Publikováno v:
Toxicology in Vitro. 18:835-840
Large numbers of lipophilic molecules are attached to fractions of serum protein, e.g. albumin, in vivo. Cell culture medium of most in vitro hepatocyte models for the prediction of metabolism does not contain albumin. Consequently, in vitro availabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33020d5e66d1f3c25d9054bb0a4494d
https://doi.org/10.1016/j.tiv.2004.04.001
https://doi.org/10.1016/j.tiv.2004.04.001
High Density Culturing of Porcine Hepatocytes Immobilized on Nonwoven Polyurethane-Based Biomatrices
Autor:
S. A. Pahernik, M. Doser, Wolfgang Erwin Thasler, M. J. Gomez-Lechon, M. J. Castell, Heinrich Planck, H.G. Koebe
Publikováno v:
Cells Tissues Organs. 168:170-177
Objective: Hepatocytes are increasingly used as functional units in bioartificial liver devices. The objective of the present study was to investigate the feasibility of culturing porcine hepatocytes in high density on a novel polyurethane-based nonw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9615b31be7de17356fc73c603d00427
https://doi.org/10.1159/000047832
https://doi.org/10.1159/000047832
Autor:
T. Donato, H.G. Koebe, Castell Jv, M. Doser, Heinrich Planck, S. A. Pahernik, M. J. Gomez-Lechon, M. Dauner, Wolfgang E. Thasler
Publikováno v:
Journal of Materials Science: Materials in Medicine. 11:37-41
A new non-woven polyetherurethane support suitable to host cultured hepatocytes has been developed. Prior to its use in bioreactors and artificial liver devices, the biocompatibility of this new material was investigated. The experiments have shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92cae3b33fc5a7926b78f95a81db8ae1
https://doi.org/10.1023/a:1008985618651
https://doi.org/10.1023/a:1008985618651
Publikováno v:
Cryobiology. 33:552-566
For clinical use of bioartifical liver devices a constant supply of primary liver cells has to be provided. Hypothermic storage of isolated pig hepatocytes could support large-scale stocking of cells. Freshly isolated pig hepatocytes from slaughterho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00703a52d95bce000de27d58b77488b2
https://doi.org/10.1006/cryo.1996.0059
https://doi.org/10.1006/cryo.1996.0059
Publikováno v:
The International Journal of Artificial Organs. 19:415-421
Hepatocytes in long-term cultures represent a promising approach to preserve liver function under standard culture conditions. Hepatocyte cultures as the key components in an extracorporeal artificial liver (EAL) in the treatment of hepatic insuffici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9858b1f982033ff0db66f360bfc7684
https://doi.org/10.1177/039139889601900707
https://doi.org/10.1177/039139889601900707
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1300:25-29
It has been suggested that chenodeoxycholic acid is preferentially formed by the alternative or 'acidic' pathway of bile acid biosynthesis starting with 27-hydroxylation of cholesterol, while cholic acid is derived from 7 alpha-hydroxycholesterol whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadf49a116db6d4a8c2021029d756bbd
https://doi.org/10.1016/0005-2760(95)00231-6
https://doi.org/10.1016/0005-2760(95)00231-6
Publikováno v:
The International Journal of Artificial Organs. 17:95-106
An easy to apply culture technique is presented that protects a monolayer configuration of liver cells within an extracellular matrix. The Immobilising Gel (IG)-Technique not only preserves hepatocyte morphology and supports a variety of differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1dd8830e279aa359f7863ed11a23ea5
https://doi.org/10.1177/039139889401700207
https://doi.org/10.1177/039139889401700207
Publikováno v:
Xenobiotica. 24:95-107
1. Primary cultures of human hepatocytes have already been employed in various applications for the study of xenobiotic metabolism. Most of these approaches were performed either on freshly isolated cells or on short-term primary cultures. Standard c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563fe075d4b1f986c3c7099ab6491f34
https://doi.org/10.3109/00498259409043224
https://doi.org/10.3109/00498259409043224
Publikováno v:
Cryobiology. 30:349-352
Self designed temperature probes with identical transmission patterns were placed at different positions within the cooling chamber of a modern cooling machine under defined conditions. Dependent on the rate of cooling, considerable differences betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c687f4f18d4d75a1cffa15c330bf546
https://doi.org/10.1006/cryo.1993.1034
https://doi.org/10.1006/cryo.1993.1034