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pro vyhledávání: '"H.F.P. Hillen"'
Honderd jaar geleden gold tuberculose nog als volksziekte nummer één, tegenwoordig komt de ziekte in Nederland nauwelijks meer voor. Omgekeerd sprak niemand in 1900 over hypertensie of een hartinfarct. Ziekten komen en gaan. Net als de reactie op d
Hoe is in de loop van de tijd gereageerd op bedreigingen van de volksgezondheid? Waar, hoe en door wie werd de daartoe benodigde kennis verworven? Hoe werd die kennis in de praktijk gebracht? Bij wie ligt eigenlijk de verantwoordelijkheid voor de gez
Autor:
H.F.P. Hillen
Publikováno v:
European Journal of Internal Medicine. 13:154-159
Sir William Osler was the Regius Professor of Medicine in Oxford at the end of World War I. In those days there was a great demand for postgraduate medical education. This was the motive for the foundation of the Fellowship of Postgraduate Medicine,
Autor:
H.F.P Hillen, W.J Mulder
Publikováno v:
European Journal of Internal Medicine. 12:327-333
In all industrialized countries, life expectancy has risen in the past 100 years. The incidence of elderly patients reaching end-stage renal disease (ESRD) and requiring renal replacement therapy has also increased. During the past few decades, the p
Publikováno v:
Acta Haematologica. 102:31-37
It has been shown that the clinical course of sickle cell (SS) patients can be ameliorated by administration of hydroxyurea (HU). Induction of hemoglobin F (HbF) is thought to be the mechanism responsible for clinical improvement in some patients. Ho
Autor:
Arjan W. Griffioen, Alice Muller, H.F.P. Hillen, A. F. Barendsz-Janson, M. C. E. Van Dam-Mieras
Publikováno v:
Journal of Vascular Research. 35:109-114
It is generally accepted that tumors are angiogenesis-dependent. For research and clinical purposes it would be very attractive to have a simple in vitro model that allows a rapid screening of the angiogenic potential of tumors and to study the effec
Publikováno v:
Acta Haematologica. 100:26-31
Hydroxyurea (HU) induces HbF production and can reduce painful crises in some patients with sickle cell anemia (SS). However, HbF induction alone cannot explain the beneficial effect of HU treatment as some patients experience clinical improvement wh
Autor:
H.F.P. Hillen, A.W. Saleh
Publikováno v:
The Netherlands Journal of Medicine. 51:169-178
In the present review the role and regulation of foetal haemoglobin (HbF) in sickle-cell disease as well as the clinical results of therapy aimed at augmenting HbF synthesis are briefly discussed. Enhanced levels of HbF have an inhibitory effect on s
Publikováno v:
The Netherlands Journal of Medicine. 51:65-77
Publikováno v:
The Netherlands Journal of Medicine. 49:42-51
In the 1970s it was first proposed that tumours depended on the establishment of a microcirculation in order to grow beyond a few millimetres. Thereafter, the search to prove this hypothesis increased strongly and by the end of the 1980s, evidence wa