Zobrazeno 1 - 10
of 60
pro vyhledávání: '"H.E. Falke"'
Publikováno v:
Food and Chemical Toxicology. 35:337-348
The acute and subacute toxicity of five biogenic amines-tyramine, spermidine, spermine, putrescine and cadaverine-were examined in Wistar rats. Tyramine and cadaverine had a low acute oral toxicity of more than 2000 mg/kg body weight. Putrescine had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52db21983b3e6ca0c549d5001e886030
https://doi.org/10.1016/s0278-6915(97)00121-x
https://doi.org/10.1016/s0278-6915(97)00121-x
Autor:
Heleen M. Wortelboer, H.E. Falke, P.J. van Bladeren, Bas J. Blaauboer, Jan Noordhoek, C.A. de Kruif, E.C.M. van der Linden
Publikováno v:
Food and Chemical Toxicology. 30:589-599
Groups of male Wistar rats were fed semi-synthetic diets containing 0, 200 or 500 mg indole-3-carbinol (13C)/kg for 2, 7, 14 or 28 days. After 2 days, P-450 activities were already induced, but the isoenzyme pattern induced was different in the liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4934fe292334a0bc3b7f5c20fec8fc
https://doi.org/10.1016/0278-6915(92)90193-o
https://doi.org/10.1016/0278-6915(92)90193-o
Autor:
Heleen M. Wortelboer, H.E. Falke, C.A. de Kruif, Jan Noordhoek, Bas J. Blaauboer, A.A.J. van Iersel, P.J. van Bladeren
Publikováno v:
Food and Chemical Toxicology. 30:17-27
Male Wistar rats were given semi-synthetic diets supplemented with 0, 2.5, 5 and 20% cooked Brussels sprouts for 2, 7, 14 or 28 days. The effects on several cytochrome P -450 enzymes and phase II enzymes (glutathione S -transferase (GST), glucuronyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24e34a5f1a0ed68fc1abbb603b0e063
https://doi.org/10.1016/0278-6915(92)90132-5
https://doi.org/10.1016/0278-6915(92)90132-5
Autor:
Heleen M. Wortelboer, C.A. de Kruif, H.E. Falke, Bas J. Blaauboer, A.A.J. van Iersel, Jan Noordhoek
Publikováno v:
Biochemical Pharmacology. 42:381-390
The metabolic profile of seven subfamilies of cytochrome P450 (P450IA, IIA, IIB, IIC, IIE, IIIA, IVA) was studied in rat liver (in vivo) and in primary hepatocyte cultures (in vitro) after treatment with various inducers. The dealkylation of 7-ethoxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3900d691b01546f35447de039169aa18
https://doi.org/10.1016/0006-2952(91)90726-l
https://doi.org/10.1016/0006-2952(91)90726-l
Autor:
C.A. de Kruif, Jan Noordhoek, H.E. Falke, Bas J. Blaauboer, Heleen M. Wortelboer, J.W. Marsman, J.C. Venekamp
Publikováno v:
Chemico-Biological Interactions. 80:303-315
The potency of indole-3-carbinol (I3C) to form condensation products under acidic aqueous conditions was studied. After identifying a known dimer, 3,3′-diindolylmethane (DIM), we elucidated the structures of two trimers also found in acid reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b42d96a4be2fc81e7ec9ad9598b623b
https://doi.org/10.1016/0009-2797(91)90090-t
https://doi.org/10.1016/0009-2797(91)90090-t
Publikováno v:
Regulatory Toxicology and Pharmacology, 2 II, 24
Erythritol is a sugar alcohol (polyol) with potential applications as a low-calorie, bulk sweetener. Ingested erythritol is efficiently absorbed and excreted unchanged via the urine since it is not metabolized systemically by the animal or human body
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552acb2d4d526fd6e6087032f1ef481a
http://resolver.tudelft.nl/uuid:ffed1f7a-6b4c-4f0a-9906-7c23f2b0c0ee
http://resolver.tudelft.nl/uuid:ffed1f7a-6b4c-4f0a-9906-7c23f2b0c0ee
Autor:
Jan Noordhoek, H.E. Falke, Bas J. Blaauboer, C.A. de Kruif, Heleen M. Wortelboer, A.A.J. van Iersel
Publikováno v:
Biochemical pharmacology. 43(7)
The effects of three acid condensation products of indole-3-carbinol (I3C), i.e. 3,3'-diindolylmethane (DIM), 5,6,11,12,17,18-hexahydrocyclonona[1,2-b:4,5-b':7,8-b"]tri-indole (CTI) and 2,3-bis[3-indolylmethyl]indole (BII), on cytochrome P450 and pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7a1b73296288d831af221693799134
https://pubmed.ncbi.nlm.nih.gov/1567468
https://pubmed.ncbi.nlm.nih.gov/1567468
Autor:
A. A. J. J. L. Rutten, Lambert Doorn, H.E. Falke, J. F. Catsburg, Ivonne M.C.M. Rietjens, R. Theelen, Bas J. Blaauboer, F. X. R. van Leeuwen, Heleen M. Wortelboer
Publikováno v:
Archives of Toxicology 66 (1992)
Archives of Toxicology, 66, 237-244
Archives of Toxicology, 66, 237-244
Assay conditions and results of cytochrome P-450 dependent 7-ethoxyresorufin (ER) and 7-pentoxyresorufin (PR) O-dealkylation (OD) by rat liver microsomes were compared by four laboratories in the Netherlands. Microsomal mixtures were prepared from co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52adee17929d6a98a26f3f2fe4355199
https://research.wur.nl/en/publications/interlaboratory-comparison-of-microsomal-ethoxyresorufin-and-pent
https://research.wur.nl/en/publications/interlaboratory-comparison-of-microsomal-ethoxyresorufin-and-pent
Autor:
Jan Noordhoek, C.A. de Kruif, H.E. Falke, A.A.J. van Iersel, Bas J. Blaauboer, Heleen M. Wortelboer
Publikováno v:
Biochemical pharmacology. 40(11)
Changes in the isoenzyme pattern of cytochrome P450 during culture were investigated in primary cultures of rat hepatocytes, measuring specific enzyme activities in microsomes prepared from cultured cells as well as in intact monolayers. Assays of 7-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f241396b64a5c9e1726451ea288862
https://pubmed.ncbi.nlm.nih.gov/2268371
https://pubmed.ncbi.nlm.nih.gov/2268371
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 28(8)
An acute (4-hr) and a sub-acute (4-wk) inhalation toxicity study of germanium metal powder (purity 99.8%, mean particle size 2.0–2.4 μm) were carried out in young adult Wistar rats. Exposure of five male and five female rats to 3.86 or 5.34 g/m 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c0df829749145a265446b0a4051b8d
https://pubmed.ncbi.nlm.nih.gov/2242832
https://pubmed.ncbi.nlm.nih.gov/2242832