Zobrazeno 1 - 10
of 29
pro vyhledávání: '"H.E. Blythman"'
Autor:
D. Carriere, D. Dussossoy, Pierre Casellas, F. K. Jansen, J. C. Laurent, P. Poncelet, B. Bourrie, M. C. Liance, G. Richer, H.E. Blythman, H. Vidal, O. Gros
Publikováno v:
Receptor-Mediated Targeting of Drugs ISBN: 9781468448641
Since 1980, immuno-A-toxins (I-A-Ts) which are conjugates between an antibody and the A-chain of a polypeptide toxin, e.g., diphtheria toxin or ricin, have been described by several laboratories as cytotoxic agents with high specificity for their tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5f2b95388f43a67a95736cab457ef1e
https://doi.org/10.1007/978-1-4684-4862-7_9
https://doi.org/10.1007/978-1-4684-4862-7_9
High Efficiency of Immunotoxin Potentiated by Lysosomotropic Amines to Specifically Kill Tumor Cells
A new class of reagents, called immunotoxins, has been synthetized, consisting of the A-ckain of ricin linked by a disulphide bridge to an antibody against defined cell surface antigens. The feasability of this approach is supported by experiments wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1feed7d604447d2d9a5151c7f701dd7d
https://doi.org/10.1016/b978-0-08-029815-3.50083-0
https://doi.org/10.1016/b978-0-08-029815-3.50083-0
Publikováno v:
Proceedings of the Fourth Lectin Meeting: Copenhagen, June 1981
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a82c4c2b7e15174a607da0ef6e987bd
https://doi.org/10.1515/9783111555928-002
https://doi.org/10.1515/9783111555928-002
Autor:
F.K. Jansen, H. Vidal, Pierre Casellas, Bernard Pau, P. Poncelet, Francis Paolucci, D. Carriere, Gilbert Richer, Pierre Gros, H.E. Blythman
The B-chain of ricin, which mediates the entry of the toxic A-chain into the cytoplasm,was efficiently replaced by antibodies. The conjugates of antibodies with the A-chain (immunotoxins) demonstrated specific cytotoxicity for their target cells. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c098c9721fa7e83f73f0feb7d2900f73
https://doi.org/10.1016/b978-0-12-494850-1.50030-x
https://doi.org/10.1016/b978-0-12-494850-1.50030-x
Immunotoxins (IT) directed against murine and human leukemias were prepared, using either a monoclonal anti-Thy 1.2 rat IgG or a monoclonal anti-T65 mouse IgG. Antibodies were coupled to the A-chain of ricin as described elsewhere. Two leukemia model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::871061aa40d016149ea17203894d41d2
https://doi.org/10.1016/b978-0-08-031739-7.50106-3
https://doi.org/10.1016/b978-0-08-031739-7.50106-3
Publikováno v:
International Journal of Immunopharmacology. 4:249
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e98b146e0ca653c27c0864749dcb0278
https://doi.org/10.1016/0192-0561(82)90075-3
https://doi.org/10.1016/0192-0561(82)90075-3
Autor:
P. Poncelet, G.A. Voisin, D. Carriere, H.E. Blythman, B. Pau, G. Richer, Pierre Casellas, F.K. Jansen
Publikováno v:
International Journal of Immunopharmacology. 2:254
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fdee0825489df49ca6dc34b64999c18
https://doi.org/10.1016/0192-0561(80)90243-x
https://doi.org/10.1016/0192-0561(80)90243-x
Publikováno v:
European Journal of Cancer and Clinical Oncology. 21:1373
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b48ef92217fb475970f7cbd44c0f5f97
https://doi.org/10.1016/0277-5379(85)90342-6
https://doi.org/10.1016/0277-5379(85)90342-6
Publikováno v:
International Journal of Immunopharmacology. 7:401
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::623d67ca5546b970ed852a625ea657ad
https://doi.org/10.1016/0192-0561(85)90451-5
https://doi.org/10.1016/0192-0561(85)90451-5