Zobrazeno 1 - 10
of 55
pro vyhledávání: '"H.B.W.M. Koëter"'
Autor:
M.K. Prinsen, H.B.W.M. Koëter
Publikováno v:
Food and Chemical Toxicology. 31:69-76
The enucleated eye test (EET) with the isolated eye of rabbits has been recognized as a valuable alternative to the Draize test, because it represents a test system nearest to the in vivo test, without the need to use live animals. In this ex vivo bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788e1e97441fe7d8185a9b9270f6ffb2
https://doi.org/10.1016/0278-6915(93)90182-x
https://doi.org/10.1016/0278-6915(93)90182-x
Autor:
H.B.W.M. Koëter
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 8(4)
Toxicity studies are conducted with a view to identifying and assessing human or environmental hazards. Thus, the key issues are those of which, and how much, information is considered necessary to make a reliable and valid assessment, and to what ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8951066eb95fce35771aff254e4f839
https://pubmed.ncbi.nlm.nih.gov/20693046
https://pubmed.ncbi.nlm.nih.gov/20693046
Autor:
H.B.W.M. Koëter
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 9(6)
In order that a proposal for an alternative to an animal test be developed as an internationally accepted guideline, there needs to be consensus on the validity of the method proposed. Over the years, considerable attempts have been made to ‘valida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f0863250fd530c77b0beada181a651
https://pubmed.ncbi.nlm.nih.gov/20650166
https://pubmed.ncbi.nlm.nih.gov/20650166
Publikováno v:
Journal of the American College of Toxicology. 11:233-248
Lactitol is a disaccharide sugar alcohol (polyol) which holds promise as a reduced calorie, noncariogenic sugar substitute. In a multigeneration reproduction study, lactitol was fed to Wistar-derived Cpb:WU rats of both sexes throughout three success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28508f74d3b62ded3737a2ae99e22aaa
https://doi.org/10.3109/10915819209141501
https://doi.org/10.3109/10915819209141501
Autor:
H.B.W.M. Koëter, A. Bär
Publikováno v:
Journal of the American College of Toxicology. 11:249-257
The embryotoxicity/teratogenicity of lactitol, a polyol sugar substitute, was examined in Wistar-derived Cpb:WU rats. Lactitol was fed at dietary concentrations of 0, 2, 5, and 10% to groups of 25 female rats which were pretreated in utero and subseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a54ce13b9a7272d9d8689c19a7eacd12
https://doi.org/10.3109/10915819209141502
https://doi.org/10.3109/10915819209141502
Publikováno v:
Toxicology. 71:173-179
An oral testicular toxicity and male fertility study was carried out in CD-1 mice with 1,3-diphenylguanidine (99.9% purity). 1,3-Diphenylguanidine was administered to male mice by daily gavage at dose levels of 0, 0.06, 0.25, 1, 4 and 16 mg/kg body w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1ce34ab062482d1923e9c247d4497a
https://doi.org/10.1016/0300-483x(92)90064-l
https://doi.org/10.1016/0300-483x(92)90064-l
Autor:
H.B.W.M. Koëter
Publikováno v:
Humanexperimental toxicology. 14(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64951b1ffdc764ea9f040c97dd176162
https://pubmed.ncbi.nlm.nih.gov/7748609
https://pubmed.ncbi.nlm.nih.gov/7748609
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 7(1)
Rabbit full thickness skin can be maintained viable for 7 days using a two-compartment organ culture model. We report that this model is useful for assessing cutaneous toxicity. 11 chemicals were each applied topically and then cytotoxicity was deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8fb79197dc32c55d867c776d706f8f
https://pubmed.ncbi.nlm.nih.gov/20732174
https://pubmed.ncbi.nlm.nih.gov/20732174
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 28(1)
The sugar replacer isomalt was fed to Wistar rats of both sexes throughout three successive generations at concentrations of 0, 2.5, 5 and 10% in the diet. A group of rats fed a diet containing 10% sucrose served as an additional control group. The i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302686962ee560c41a749751d7c9866e
https://pubmed.ncbi.nlm.nih.gov/2138113
https://pubmed.ncbi.nlm.nih.gov/2138113
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 28(1)
The embryotoxicity/teratogenicity of the sugar replacer isomalt was studied in Wistar rats and New Zealand White rabbits. Groups of 22–23 female rats were given diets containing isomalt at concentrations of 2.5, 5 or 10%, from day 0 to day 21 of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53017a15cd0d29d2e0701c04ae6b87a4
https://pubmed.ncbi.nlm.nih.gov/2312011
https://pubmed.ncbi.nlm.nih.gov/2312011