Zobrazeno 1 - 10
of 97
pro vyhledávání: '"H.A. Leaver"'
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 20:455-463
Objectives: Major thoracic surgery is associated with trauma-related immunological changes. These may impair anti-tumour immunity. We hypothesize that the reduced operative trauma associated with a video-assisted thoracic surgery (VATS) approach may
Autor:
Ian R. Whittle, R J Prescott, H.A. Leaver, James W. Ironside, B. H. Su, A. Gregor, E.P. Miller, J R Williams
Publikováno v:
European Journal of Clinical Investigation. 29:220-231
Background Reactive oxygen intermediates (ROIs) are important signals controlling cell growth and cell death. Local essential fatty acid (EFA) deficiencies in tumour cells may limit tumour ROI generation. This deficiency may be rectified by the addit
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 58:193-200
It has been postulated that loss of proliferative control in tumour cells is a consequence of depletion of cellular arachidonic acid (AA) and that exogenous AA and n-6 fatty acids may restore control of proliferation. To test this hypothesis and to i
Publikováno v:
British Journal of Neurosurgery. 12:539-546
Apoptosis, or programmed cell death, has been recognized for nearly three decades as occurring in many organs in response to different pathophysiological stimuli. It is now recognized as one of the fundamental cellular biological processes. In human
Autor:
J R Williams, James W. Ironside, A. Gregor, Ian R. Whittle, B. H. Su, S. R. Craig, H.A. Leaver, P. L. Yap
Publikováno v:
Annals of the New York Academy of Sciences. 832:200-214
Autor:
P.L. Yap, D.C. Carter, Robin J Prescott, Jian-Hua Mao, G.M. Raab, B. H. Su, W.B. Ross, W. Qian, H.A. Leaver
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 49:945-953
The widespread use of blood transfusion in major surgical procedures has led to concern about the immunosuppressive effect of transfusion on patients with underlying malignancy. Transfusion may also suppress the host response to infection. The cellul
Publikováno v:
FEMS Microbiology Letters. 105:261-270
In contrast to the phorbol ester oxidative response, which only develops during dimethylsulphoxide (DMSO)-induced differentiation of the human leukemic myeloblast HL-60 cell-line, the endotoxin response was observed in undifferentiated and differenti
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 42:217-224
The abnormal uterine activity associated with dietary n-3 fatty acids may result from competitive inhibition of PG2 production. Uterine synthesis of 2- and 3-series prostaglandins F(PGF) and E(PGE) was studied using mass spectrophotometry in rats fed
Publikováno v:
FEMS Microbiology Letters. 64:321-325
The transfusion of blood is associated with long-term immunosuppression, which has been postulated to influence immunosurveillance and cancer cell killing. The mononuclear phagocyte synthesises large quantities of PGE2, and PGE2 has been shown to inh
Publikováno v:
Immunopharmacology. 20:105-113
The role of platelet-activating factor (PAF) in human endotoxaemia was investigated by incubating human monocytes from 27 subjects with S. minnesota endotoxin in vitro. Monocytes synthesized 1.01 +/- 0.4 x 10(-10) M to 5.3 +/- 1.51 x 10(-9) M PAF aft