Zobrazeno 1 - 10
of 174
pro vyhledávání: '"H.-W. Vohr"'
Publikováno v:
Toxicology in Vitro. 25:1966-1973
Alternative methods for the prediction of immunotoxicity are highly desirable. However, until now no in vitro test for this purpose has been fully validated or accepted by regulatory authorities. MD cultures are in vitro equivalent to the widely used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c01e3dc2111664ce7f99fb9ce45931e
https://doi.org/10.1016/j.tiv.2011.06.020
https://doi.org/10.1016/j.tiv.2011.06.020
Autor:
H.-W. Vohr, L.-M. Koeper
Publikováno v:
Food and Chemical Toxicology. 47:110-118
An increasing aim in safety assessment of chemicals and drugs is to reduce, refine and replace animal testing, especially in the context of the new system for the registration, evaluation and authorisation of chemicals (REACH). Regarding immunosuppre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596e75c8a1f05b095af60a497d4bca64
https://doi.org/10.1016/j.fct.2008.10.025
https://doi.org/10.1016/j.fct.2008.10.025
Autor:
A. Heusener, Peter Ulrich, G. Ehling, M. Hecht, Th. Maurer, K. Riecke, J. Huesler, L. Ullmann, H. van Loveren, A.O. Gamer, Rob J. Vandebriel, H.-W. Vohr
Publikováno v:
Toxicology. 212:69-79
The original local lymph node assay (LLNA) is based on the use of radioactive labelling to measure cell proliferation. Other endpoints for the assessment of proliferation are also authorized by the OECD Guideline 429 provided there is appropriate sci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fbdcd0e055150df90c857fb0ccbbc0e
https://doi.org/10.1016/j.tox.2004.12.038
https://doi.org/10.1016/j.tox.2004.12.038
Autor:
S. Allen, P. Botham, L. Tilbury, H.-W. Vohr, Constance M. Wiemann, S. de Jouffrey, N.G. Carmichael, M. Urtizberea, X. Manciaux
Publikováno v:
Food and Chemical Toxicology. 43:65-75
Assessment of skin sensitization potential is a mandatory requirement for the registration or notification of most types of chemicals and products. Until recently, two methods using the guinea pig as test model were the most widely accepted; the guin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de9938f4a7372f0c33c82b25a2bc814
https://doi.org/10.1016/j.fct.2004.08.013
https://doi.org/10.1016/j.fct.2004.08.013
Autor:
D. A. Basketter, G. F. Gerberick, Ian Kimber, M Butler, C Newsome, A. Gamer, W. Steiling, H.-W. Vohr, J.-L. Garrigue
Publikováno v:
Food and Chemical Toxicology. 41:1799-1809
It is clear that contact allergens vary substantially with regard to the relative potency with which they are able to induce skin sensitisation. Considerations of potency will in the future become a significant factor in the classification of skin se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87841ad5bdb17cee38bec4ad10781d2
https://doi.org/10.1016/s0278-6915(03)00223-0
https://doi.org/10.1016/s0278-6915(03)00223-0
Publikováno v:
Annals of the Rheumatic Diseases. 57:220-225
OBJECTIVE—The autoantigen p68 is a target of autoantibodies as well as autoreactive T cells with a high specificity in rheumatoid arthritis (RA). The binding characteristics of the autoantibodies to their antigen were now analysed biochemically and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a988ff3de64132447eea4439f22f079
https://doi.org/10.1136/ard.57.4.220
https://doi.org/10.1136/ard.57.4.220
Publikováno v:
British Journal of Dermatology. 134:904-909
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88262662af82394a89aa9228618f833f
https://doi.org/10.1111/j.1365-2133.1996.tb06323.x
https://doi.org/10.1111/j.1365-2133.1996.tb06323.x
Autor:
Michael Kammüller, Ian Kimber, Scott E. Loveless, Thomas T. Kawabata, D.A. Stringer, D. A. Basketter, H.-W. Vohr, S. Magda, T.H.M. Pal, J.N. Bremmer
Publikováno v:
Food and Chemical Toxicology. 32:289-296
In the context of this paper, immunotoxicity is taken to encompass immunosuppression/immunopotentiation and allergy. Over the last 10 to 15 years, well characterized methods for the assessment of altered immune competence have been reported. This has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34a2f66db4f7002012107eaaae205c8
https://doi.org/10.1016/0278-6915(94)90203-8
https://doi.org/10.1016/0278-6915(94)90203-8
Publikováno v:
The Journal of Immunology. 146:3006-3011
Previous studies have established that in susceptible mouse strains, such as A.SW (H-2s), repeated injections of subtoxic doses of HgCl2 induce increased serum levels of total IgE and IgG1, high serum titers of antinuclear autoantibodies (ANo1A), and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8697e01c0edf68f998dbcf813a8c91f
https://doi.org/10.4049/jimmunol.146.9.3006
https://doi.org/10.4049/jimmunol.146.9.3006