Zobrazeno 1 - 10
of 10
pro vyhledávání: '"H.-Kam Cheung"'
Autor:
Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries, Carolien P. Schröder, Anton G.T. Terwisscha van Scheltinga, H. Kam Cheung, Alexander Sternjak, Matthias Friedrich, Sabine Stienen, Frank J. Warnders, Stijn J.H. Waaijer
Purpose: AMG 211, a bispecific T-cell engager (BiTE) antibody construct, targets carcinoembryonic antigen (CEA) and the CD3 epsilon subunit of the human T-cell receptor. AMG 211 was labeled with zirconium-89 (89Zr) or fluorescent dye to evaluate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef2a933f924d3d901ce5cf7df51972b
https://doi.org/10.1158/1078-0432.c.6529296.v1
https://doi.org/10.1158/1078-0432.c.6529296.v1
Autor:
Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries, Carolien P. Schröder, Anton G.T. Terwisscha van Scheltinga, H. Kam Cheung, Alexander Sternjak, Matthias Friedrich, Sabine Stienen, Frank J. Warnders, Stijn J.H. Waaijer
Supplementary Figures S1-S4 and Supplementary Table S1 including Supplementary Figure legend and Supplementary Table caption Figure S1. Flow chart of the drug substance (N-sucDf-AMG211) manufacturing process and drug product (89Zr-AMG211) formulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073c21bb4b1fb1b2e518864fa651aaeb
https://doi.org/10.1158/1078-0432.22476105
https://doi.org/10.1158/1078-0432.22476105
Autor:
Elisabeth G.E. de Vries, H. Kam Cheung, Anton G.T. Terwisscha van Scheltinga, Frank J. Warnders, Marjolijn N. Lub-de Hooge, Carolien P. Schröder, Stijn J.H. Waaijer, Sabine Stienen, Alexander Sternjak, Matthias Friedrich
Publikováno v:
Clinical Cancer Research, 24(20), 4988-4996. AMER ASSOC CANCER RESEARCH
Purpose: AMG 211, a bispecific T-cell engager (BiTE) antibody construct, targets carcinoembryonic antigen (CEA) and the CD3 epsilon subunit of the human T-cell receptor. AMG 211 was labeled with zirconium-89 (89Zr) or fluorescent dye to evaluate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da049d28f4c2be21fb052068b88670c7
https://europepmc.org/articles/PMC6193542/
https://europepmc.org/articles/PMC6193542/
Autor:
Robert M. Arduini, Mary Beth Carter, Wen-Cherng Lee, Feng Shan, Xiamei Zhang, Juswinder Singh, Jessica E. Friedman, H.-Kam Cheung, Alan Gill, Mark Cornebise, Harry Sweigard, Donald Costa, Kai Fu, Michael J. Choi, Scott Bowes, P. Ann Boriack-Sjodin, Serene Josiah, Dongyu Sun, Michael J. Corbley, Claudio Chuaqui, Miki N. Newman, Jonathan N. Mead, Lihong Sun, James L. Papadatos, Leona E. Ling, Xin Zhang, Frank Lutterodt
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:665-671
Objective— TGF-β plays a significant role in vascular injury-induced stenosis. This study evaluates the efficacy of a novel, small molecule inhibitor of ALK5/ALK4 kinase, in the rat carotid injury model of vascular fibrosis. Methods and Results—
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0432a527297b30567075fe66b68c2c0f
https://doi.org/10.1161/atvbaha.107.158030
https://doi.org/10.1161/atvbaha.107.158030
Autor:
Timothy Pontz, Michael J. Corbley, Claudio Chuaqui, Miki N. Newman, Scott Bowes, Juswinder Singh, Serene Josiah, H.-Kam Cheung, Robert M. Arduini, P. Ann Boriack-Sjodin, Wen-Cherng Lee, Jonathan N. Mead, Leona E. Ling, James L. Papadatos
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4355-4359
We describe the discovery, using shape-based virtual screening, of a potent, ATP site-directed inhibitor of the TbetaRI kinase, an important and novel drug target for fibrosis and cancer. The first detailed report of a TbetaRI kinase small molecule c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43158838d319a721aec3c97f872baa6d
https://doi.org/10.1016/j.bmcl.2003.09.028
https://doi.org/10.1016/j.bmcl.2003.09.028
Autor:
Jonathan N. Mead, Feng Shan, Juswinder Singh, Lihong Sun, Michael J. Corbley, Serene Josiah, Claudio Chuaqui, H.-Kam Cheung, Xiamei Zhang, Erika Lorraine Silverio, P. Ann Boriack-Sjodin, Timothy Pontz, Scott Bowes, Miki N. Newman, Leona E. Ling, James L. Papadatos, Doreen Lepage, Robert M. Arduini, Wen-Cherng Lee
Publikováno v:
Transforming Growth Factor-β in Cancer Therapy, Volume II ISBN: 9781588297150
The multifunctional cytokine, TGF-β, is often overexpressed in human tumors and in preclinical studies has been demonstrated to have autocrine and paracrine protumor activities including immune evasion, invasiveness, epithelial to mesenchymal transi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca322a8bc362e1edd29b79e1a404b73
https://doi.org/10.1007/978-1-59745-293-9_41
https://doi.org/10.1007/978-1-59745-293-9_41
Autor:
Lihong Sun, Michael J. Corbley, Wen-Cherng Lee, Samuel Kim, Xiamei Zhang, Feng Shan, Juswinder Singh, H.-Kam Cheung, Steven M. Albelda, Eiji Suzuki, Leona E. Ling
Publikováno v:
Cancer research. 67(5)
Malignant mesothelioma is an aggressive and lethal pleural cancer that overexpresses transforming growth factor β (TGFβ). We investigated the efficacy of a novel small-molecule TGFβ type I receptor (ALK5) kinase inhibitor, SM16, in the AB12 syngen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8febdda28979db3cb2e40cead28241c
https://pubmed.ncbi.nlm.nih.gov/17332368
https://pubmed.ncbi.nlm.nih.gov/17332368
Autor:
Veena Kapoor, Peter DeLong, Eiji Suzuki, H.-Kam Cheung, Steven M. Albelda, Leona E. Ling, Larry R. Kaiser
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 10(17)
Purpose: Transforming growth factor (TGF)-β blockade has been proposed as an anticancer therapy; however, understanding which tumor patients might benefit most from such therapy is crucial. An ideal target of such inhibitory therapy might be maligna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2212ecd6be5c0913a3689951d00681f1
https://pubmed.ncbi.nlm.nih.gov/15355924
https://pubmed.ncbi.nlm.nih.gov/15355924
Autor:
Michael J. Corbley, Claudio Chuaqui, Timothy Pontz, Scott Bowes, Leona E. Ling, Serene Josiah, P. Ann Boriack-Sjodin, Miki N. Newman, James L. Papadatos, Juswinder Singh, H.-Kam Cheung, Robert M. Arduini, Jonathan N. Mead, Wen-Cherng Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2991
Corrigendum to ‘‘Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFb receptor kinase (TbRI)’’ [Bioorg. Med. Chem. Lett. 13 (2003) 4355] Juswinder Singh,* Claudio E. Chuaqui, P. Ann Boriack-Sjodin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cbd12d122e1e4c470ecccbad10d8eec
https://doi.org/10.1016/j.bmcl.2004.03.027
https://doi.org/10.1016/j.bmcl.2004.03.027
Autor:
Sonia B. Jakowlew
Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatmen