Zobrazeno 1 - 10
of 27
pro vyhledávání: '"H.-J. Röthig"'
Autor:
Adam F. Cohen, H. J. Röthig, H. G. Luus, M. Seibert-Grafe, Rik C. Schoemaker, J. M. T. Van Griensven
Publikováno v:
European Journal of Clinical Pharmacology. 47:513-518
The pharmacokinetics and pharmacodynamics of the prodrug ramipril and its active ACE-inhibiting metabolite ramiprilat were investigated in an open, randomised, three-way cross-over study in 12 healthy male volunteers. Subjects received 2.5 mg ramipri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72ad2a52029ce1f4539db92a38d6b85
https://doi.org/10.1007/bf00193704
https://doi.org/10.1007/bf00193704
Autor:
H J, Röthig
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 16(7)
Gene/biotechnology products can be either physiological peptides for the purpose of substitution of deficiencies or for therapeutic purposes in superphysiological concentrations, or nonphysiological peptides, or newer biotechnology products like mono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b231ce7ae91ad5220f6ed85f7c71929
https://pubmed.ncbi.nlm.nih.gov/7885081
https://pubmed.ncbi.nlm.nih.gov/7885081
Autor:
Philip N. Badenhorst, H. Grötsch, F. O. Müller, H.-J. Röthig, Mattheus G. Lötter, B. Rosenkranz, H. G. Luus, B. H. Meyer
Hirudin is a selective thrombin inhibitor with strong anticoagulant properties which could elicit gastro-intestinal bleeding. A double-blind cross-over study of the effects of hirudin on gastro-intestinal bleeding was therefore conducted on 12 health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d35a355eed7ad4b0e5a944f042f384e
https://europepmc.org/articles/PMC1381442/
https://europepmc.org/articles/PMC1381442/
Publikováno v:
International journal of clinical pharmacology, therapy, and toxicology. 30(4)
Twelve consenting, caucasian male volunteers participated in a double-blind, randomized, crossover study of the effects of felodipine, a calcium antagonist, on the pharmacokinetics of diazepam. There were two trial periods of 12 days each with a wash
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c475638e2b5ac5cfda9fc49e401ed5c7
https://pubmed.ncbi.nlm.nih.gov/1572756
https://pubmed.ncbi.nlm.nih.gov/1572756
Safety, tolerance and pharmacokinetics of cefpirome administered intramuscularly to healthy subjects
Publikováno v:
The Journal of antimicrobial chemotherapy. 29
The pharmacokinetics of cefpirome were studied in healthy male subjects following single (0.5, 1.0 and 2.0 g) and multiple (1.0 g every 12 h for 3.5 days) intramuscular injections. High pressure liquid chromatography was used to determine cefpirome c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c93b9c938cdb95b7b6f6031480b803d
https://pubmed.ncbi.nlm.nih.gov/1601759
https://pubmed.ncbi.nlm.nih.gov/1601759
Publikováno v:
Pharmaceutical research. 8(2)
The pharmacokinetics and pharmacodynamics of methylprednisolone were investigated after intravenous administration of methylprednisolone phosphate to healthy subjects at seven different doses (16 to 1000 mg). Forty different pharmacodynamic parameter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df1bd154cd8e962480844823dc6a7a26
https://pubmed.ncbi.nlm.nih.gov/2023879
https://pubmed.ncbi.nlm.nih.gov/2023879
Publikováno v:
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 78(5)
A new anticoagulant, recombinant hirudin, was given to healthy volunteers (5 per test dose) in single intravenous doses of 0.01, 0.02, 0.04, 0.07 and 0.1 mg/kg to study its anticoagulant effects, how it was tolerated and its pharmacokinetics. Hirudin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21afde49dd877de34d436b481def3d48
https://pubmed.ncbi.nlm.nih.gov/2392724
https://pubmed.ncbi.nlm.nih.gov/2392724
Publikováno v:
Biochemical Journal. 200:449-452
The excretion of N tau-methylhistidine and creatinine was determined in a totally paralysed patient wih neither macroscopic nor microscopic detectable skeletal-muscle tissue. In this subject, it was possible for the first time to measure the basal no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29f5479a95f3f148e5d5b88bc289af6
https://doi.org/10.1042/bj2000449
https://doi.org/10.1042/bj2000449
Autor:
H. Przuntek, H. G. Mertens, J. Hilfenhaus, P. Krauseneck, Ulrich Bogdahn, H. J. Röthig, B. Fleischer
Publikováno v:
Journal of Neuro-Oncology. 3:125-130
In 3 patients with low-grade astrocytomas clinical pharmacology of interferon-beta (10(7) U/mg protein) was investigated. Interferon-beta with escalating dosage (2.3, 6.9, 23, 69 X 10(6) U/patient) was given to each patient in 4 infusions at weekly t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b4dc35d51865da13ce8fbd1b0aa0d8
https://doi.org/10.1007/bf02228888
https://doi.org/10.1007/bf02228888
Publikováno v:
Muscle & Nerve. 7:374-379
The daily urinary excretions of N tau-methylhistidine and creatinine from 52 adult patients were measured under standardized conditions. The ratio of N tau-methylhistidine to creatinine excretion was calculated on the basis of the total and muscle-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9e87ad9337b99ee2ae15486ae15e367
https://doi.org/10.1002/mus.880070506
https://doi.org/10.1002/mus.880070506