Výsledky vyhledávání - "H.-J. M. Brinkman"

In vitro assessment, using thrombin generation, of the applicability of prothrombin complex concentrate as an antidote for Rivaroxaban

Autor: P.J. Molenaar, Marisa Ninivaggi, H.-J. M. Brinkman, B. de Laat, J. Dinkelaar, Anja Leyte

Publikováno v: Journal of Thrombosis and Haemostasis, 11(6), 1111-1118. Wiley

Summary Background Rivaroxaban has been approved as an antithrombotic agent for prevention of venous thromboembolism with specific indications. At present no antidote is appointed and no guidelines have been formulated for the measurement of Rivaroxa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24f8bd23a4c5b381ae67510333e4381
https://doi.org/10.1111/jth.12236

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Patient-derived monoclonal antibodies directed towards beta(2) glycoprotein-1 display lupus anticoagulant activity

Autor: P. G. De Groot, Jan Voorberg, Mariëtte Boon-Spijker, Koen Mertens, I. Dienava-Verdoold, B. de Laat, R. H. W. M. Derksen, H.-J. M. Brinkman

Publikováno v: Journal of thrombosis and haemostasis, 9(4), 738-747. Wiley-Blackwell
Journal of Thrombosis and Haemostasis, 9(4), 738-747. Wiley

Patients with antiphospholipid syndrome (APS) display a heterogeneous population of antibodies with beta(2) glycoprotein-1 (?(2)GP1) as the major antigen.We isolated and characterized human mAbs directed against ?(2)GP1 from the immune repertoire of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ef14fc7b1b80a7f54b1c01cac661cc
https://doi.org/10.1111/j.1538-7836.2011.04212.x

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Endothelial cell activation in thrombotic thrombocytopenic purpura (TTP): a prospective analysis

Autor: Sabina Kersting, H.-J. M. Brinkman, Rob Fijnheer, Thalia Romani de Wit, Jan A. van Mourik, Ronald J. Hené

Publikováno v: British Journal of Haematology. 123:522-527

Summary. It is generally assumed that endothelial cell injury is the primary event in the pathogenesis of thrombotic thrombocytopenic purpura (TTP). In this study, we have determined the extent of vascular perturbation during acute episodes of the di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4658d064a61c1748d728d56f31289b2f
https://doi.org/10.1046/j.1365-2141.2003.04645.x

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Phospholipid-Binding Domain of Factor VIII Is Involved in Endothelial Cell–Mediated Activation of Factor X by Factor IXa

Autor: H.-J. M. Brinkman, Jan A. van Mourik, Koen Mertens

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 22:511-516

Apparently quiescent, nonapoptotic endothelial cells mediate the activation of factor X by activated factor IX in the presence of its cofactor, activated factor VIII. In a previous study, we reported that during the activation of factor X, the intera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db60b0fb2a1b62ac0324b33e7ee4dd45
https://doi.org/10.1161/hq0302.105359

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Factor seven activating protease (FSAP): does it activate factor VII?

Autor: Koen Mertens, Alexander B. Meijer, I. Dienava-Verdoold, H.-J. M. Brinkman, Mariëtte Boon-Spijker, Fabian Stavenuiter

Publikováno v: Journal of thrombosis and haemostasis : JTH. 10(5)

Summary. Background: Factor seven activating protease (FSAP) was initially reported as an activator of single-chain urokinase-type plasminogen activator (scuPA) and factor VII (FVII). Subsequently, numerous additional substrates have been identified,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db1cdaf4555d4f7d812ebf75138ce43
https://pubmed.ncbi.nlm.nih.gov/22394423

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The activation of human blood coagulation factor X on the surface of endothelial cells: a comparison with various vascular cells, platelets and monocytes

Autor: Koen Mertens, K. Grijm, L. Zwart-Huinink, H.-J. M. Brinkman, Joost C. M. Holthuis, J. A. Van Mourik

Publikováno v: British Journal of Haematology. 87:332-342

Rates of factor X activation on endothelial cells were compared with activation rates on other vascular cells, platelets, monocytes and negatively charged phospholipid vesicles. Factor VIIa-mediated factor X activation was observed on smooth muscle c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065b575e283701e298aa07184e35feeb
https://doi.org/10.1111/j.1365-2141.1994.tb04918.x

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Involvement of Cyclooxygenase- and Lipoxygenase-Mediated Conversion of Arachidonic Acid in Controlling Human Vascular Smooth Muscle Cell Proliferation

Autor: M.F. van Buul-Wortelboer, J. A. Van Mourik, H.-J. M. Brinkman

Publikováno v: Thrombosis and Haemostasis. 63:291-297

SummaryWe observed that the growth of human umbilical arterysmooth muscle cells was inhibited by the phospholipase A2 inhibitors p-bromophenacylbromide and mepacrine. Thesefindings suggest that fatty acid metabolism might be integrated in the control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abf7e41c2640d35a27ab24efc7011a82
https://doi.org/10.1055/s-0038-1645212

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Von Willebrand factor targets IL-8 to Weibel-Palade bodies in an endothelial cell line

Autor: Jan A. van Mourik, Rozalia T.M de Laaf, Jan Voorberg, Thalia Romani de Wit, Erica Sellink, Mariska G. Rondaij, Hubert P. J. C. de Leeuw, H.-J. M. Brinkman

Publikováno v: Experimental cell research, 286(1), 67-74. Academic Press Inc.

Vascular endothelial cells are able to store the chemotactic cytokine interleukin-8 (IL-8) in specialized storage vesicles, Weibel-Palade bodies, together with von Willebrand factor (VWF) and P-selectin. We investigated whether VWF plays a role in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5820b46c3c9b9dd378551dc1c7110d
https://pubmed.ncbi.nlm.nih.gov/12729795

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Assembly of multimeric von Willebrand factor directs sorting of P-selectin

Autor: H.-J. M. Brinkman, C. Hop, Hans Pannekoek, Ian R. Peake, Martina E. Daly, Andrea Guilliatt, H. P. J. C. De Leeuw, J. A. Van Mourik

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 20(7), 1763-1768. Lippincott Williams and Wilkins

Abstract —We designed a model system to study the role of von Willebrand factor (vWF) in the sorting of P-selectin and the biogenesis of Weibel-Palade body (WPB)–like organelles. For that purpose, a human epithelial cell line (T24) that synthesiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf562922ba8d184cb83226cd5549c6b0
https://pubmed.ncbi.nlm.nih.gov/10894814

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Autor: J. A. Van Mourik, P. M. Koster, H.-J. M. Brinkman, Koen Mertens

Publikováno v: The Biochemical journal. 323

A localized and regulated cascade of proteolytic events is a prerequisite for normal haemostasis. The activation of factor X by activated factor IX (factor IXa) in the presence of activated factor VIII (factor VIIIa) is essential for the formation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a0da863d8963796a701157375fd5b3
https://pubmed.ncbi.nlm.nih.gov/9169607

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