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of 133
pro vyhledávání: '"H.-G. Knaus"'
Akademický článek
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Autor:
H.-G. Knaus, Lie Chen, Heather McClafferty, Michael J. Shipston, Lijun Tian, Peter Ruth, Franziska Steeb, Danlei Bi
Publikováno v:
The Journal of Biological Chemistry
Chen, L, Bi, D, Tian, L, McClafferty, H, Steeb, F, Ruth, P, Knaus, H G & Shipston, M J 2013, ' Palmitoylation of the β4-Subunit Regulates Surface Expression of Large Conductance Calcium-activated Potassium Channel Splice Variants ', Journal of Biological Chemistry, vol. 288, no. 18, pp. 13136-13144 . https://doi.org/10.1074/jbc.M113.461830
Chen, L, Bi, D, Tian, L, McClafferty, H, Steeb, F, Ruth, P, Knaus, H G & Shipston, M J 2013, ' Palmitoylation of the β4-Subunit Regulates Surface Expression of Large Conductance Calcium-activated Potassium Channel Splice Variants ', Journal of Biological Chemistry, vol. 288, no. 18, pp. 13136-13144 . https://doi.org/10.1074/jbc.M113.461830
Background: The role of post-translational modification of regulatory β-subunits in the control of large conductance potassium (BK) channels is largely unknown. Results: β4-subunit palmitoylation controls surface trafficking of BK channel α-subuni
Autor:
Iain Rowe, Heather McClafferty, Nina Geiger, H.-G. Knaus, Owen Jeffries, Lijun Tian, Peter Ruth, Danlei Bi, Michael J. Shipston, Lie Chen
Publikováno v:
The Journal of Biological Chemistry
Jeffries, O, Geiger, N, Rowe, I C M, Tian, L J, McClafferty, H, Chen, L, Bi, D L, Knaus, H G, Ruth, P & Shipston, M J 2010, ' Palmitoylation of the S0-S1 Linker Regulates Cell Surface Expression of Voltage-and Calcium-activated Potassium (BK) Channels ', Journal of Biological Chemistry, vol. 285, no. 43, pp. 33307-33314 . https://doi.org/10.1074/jbc.M110.153940
Jeffries, O, Geiger, N, Rowe, I C M, Tian, L J, McClafferty, H, Chen, L, Bi, D L, Knaus, H G, Ruth, P & Shipston, M J 2010, ' Palmitoylation of the S0-S1 Linker Regulates Cell Surface Expression of Voltage-and Calcium-activated Potassium (BK) Channels ', Journal of Biological Chemistry, vol. 285, no. 43, pp. 33307-33314 . https://doi.org/10.1074/jbc.M110.153940
S-Palmitoylation is rapidly emerging as an important post-translational mechanism to regulate ion channels. We have previously demonstrated that large conductance calcium-and voltage-activated potassium (BK) channels are palmitoylated within an alter
Autor:
Claudia A. Sailer, John P. Adelman, Timothy Strassmaier, Chris T. Bond, H.-G. Knaus, James Maylie
Publikováno v:
Journal of Biological Chemistry. 280:21231-21236
The SK2 subtype of small conductance Ca2+-activated K+ channels is widely distributed throughout the central nervous system and modulates neuronal excitability by contributing to the afterhyperpolarization that follows an action potential. Western bl
Akademický článek
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Autor:
H-G. Knaus, Hans Zischka, Nikolaus Plesnila, Matthias Höllerhage, Carsten Culmsee, Günter U. Höglinger, A de Andrade, Lilja Meissner, Amalia M. Dolga, P Christophersen
Publikováno v:
Cell Death & Disease
Cell death & disease 5(1), e999-e999 (2014). doi:10.1038/cddis.2013.530
Cell death & disease 5(1), e999-e999 (2014). doi:10.1038/cddis.2013.530
Small-conductance Ca(2+)-activated K(+) channel activation is an emerging therapeutic approach for treatment of neurological diseases, including stroke, amyotrophic lateral sclerosis and schizophrenia. Our previous studies showed that activation of S
Autor:
P, Eller, S, Berjukov, S, Wanner, I, Huber, S, Hering, H G, Knaus, G, Toth, S D, Kimball, J, Striessnig
Publikováno v:
British journal of pharmacology. 130(3)
Mibefradil is a novel Ca(2+) antagonist which blocks both high-voltage activated and low voltage-activated Ca(2+) channels. Although L-type Ca(2+) channel block was demonstrated in functional experiments its molecular interaction with the channel has
Autor:
M L, Garcia, K M, Giangiacomo, M, Hanner, H G, Knaus, O B, McManus, W A, Schmalhofer, G J, Kaczorowski
Publikováno v:
Methods in enzymology. 294
Publikováno v:
Methods in enzymology. 294
The search for peptidyl inhibitors of K+ channels is a very active area of investigation. In addition to scorpion venoms, other venom sources have been investigated; all of these sources have yielded novel peptides with interesting properties. For in
Autor:
M, Hanner, R, Vianna-Jorge, A, Kamassah, W A, Schmalhofer, H G, Knaus, G J, Kaczorowski, M L, Garcia
Publikováno v:
The Journal of biological chemistry. 273(26)
Coexpression of alpha and beta subunits of the high conductance Ca2+-activated K+ (maxi-K) channel leads to a 50-fold increase in the affinity for 125I-charybdotoxin (125I-ChTX) as compared with when the alpha subunit is expressed alone (Hanner, M.,