Výsledky vyhledávání - "H.-G. Capraro"

Synthesis and Pharmacological Evaluation of CGP 57813 and CGP 61755, HIV-1 Protease Inhibitors from the Phe-c-Phe Peptidomimetic Class

Autor: M. Lang, G. Bold, R. M. Cozens, J. Mestan, B Poncioni, H.-G. Capraro, J. L. Rösel, A. Fässler, D. Stover

Publikováno v: Antiviral Chemistry and Chemotherapy. 7:294-299

In this report we describe the enzyme inhibitory, antiviral and pharmacokinetic properties of CGP 57813 and CGP 61755, structural analogues of CGP 53437 that were synthesized in an attempt to obtain human immunodeficiency virus type 1 (HIV-1) proteas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6c101e7fc95dde4d17ca277f9043a50
https://doi.org/10.1177/095632029600700602

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CGP 55398, a liposomal Ge(IV) phthalocyanine bearing two axially ligated cholesterol moieties: a new potential agent for photodynamic therapy of tumours

Autor: K. Schieweck, Carla Milanesi, Anna Segalla, Giulio Jori, U. Isele, H. G. Capraro

Publikováno v: British Journal of Cancer

Ge(IV) phthalocyanine (GePc) with two axially ligated cholesterol moieties was prepared by chemical synthesis and incorporated in a monomeric state into small unilamellar liposomes (CGP 55398). Upon photoexcitation with light wavelengths around its i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e3513eef310a0220a74c0f33a83da2
http://europepmc.org/articles/PMC1968893

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Structure-based design of potent CDK1 inhibitors derived from olomoucine

Autor: P, Furet, J, Zimmermann, H G, Capraro, T, Meyer, P, Imbach

Publikováno v: Journal of computer-aided molecular design. 14(5)

Cyclin-dependent kinase 1 (CDK1), an enzyme participating in the regulation of the cell cycle, constitutes a possible target in the search for new antitumor agents. Starting from the purine derivative olomoucine and following a structure-based approa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::591fadec5e3e59400610d726e9427612
https://pubmed.ncbi.nlm.nih.gov/10896313

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Profile of CGP 61755: a novel and potent HIV-1 protease inhibitor that shows enhanced anti-HIV activity when combined with other antiretroviral agents in vitro

Autor: J K, Lazdins, G, Bold, H G, Capraro, R, Cozens, A, Fässler, G, Flesch, T, Klimkait, M, Lang, J, Mestan, B, Poncioni, J, Rösel, D, Stover, M, Tintelnot-Blomley, M R, Walker, K, Woods-Cook

Publikováno v: Schweizerische medizinische Wochenschrift. 126(43)

CGP 61755 is a novel hydroxyethylene derivative produced by a high yield 10 step chemical synthesis. It is highly specific for HIV-1 protease with an IC50 of 1 nM. The ED90 in MT-2, PBLs and macrophages is infected with laboratory strains of HIV-1 or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::565713f4d2a48b989634c494dd7cd9f9
https://pubmed.ncbi.nlm.nih.gov/8916294

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Colchicine binding to antibodies

Autor: J Wolff, G H Cook, H G Capraro, Arnold Brossi

Publikováno v: Journal of Biological Chemistry. 255:7144-7148

Antibodies to colchicine have been prepared by injecting rabbits with an antigen prepared by coupling deacetylcolchicine to bovine serum albumin with a water-soluble carbodiimide. Sera of high titer were obtained with apparent dissociation constants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2dda2490d6a11314a3c9879573c7d2f5
https://doi.org/10.1016/s0021-9258(20)79677-8

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Biological effects of modified colchicines. Improved preparation of 2-demethylcolchicine, 3-demethylcolchicine, and (+)-colchicine and reassignment of the position of the double bond in dehydro-7-deacetamidocolchicines

Autor: Colin F. Chignell, Arnold Brossi, R. H. Sik, H.-G. Capraro, Thomas H. Williams, L. Atwell, M Rösner, and Arthur E. Jacobson, M. A. Iorio

Publikováno v: Journal of medicinal chemistry. 24(3)

A variety of colchicine, demecolcine, and isocolchicine derivatives were examined for their potency in the lymphocytic leukemia P388 screen in mice, for their toxicity in mice, and for their binding to microtubule protein. A qualitatively direct corr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af796ae0ac56c3509845fc7d9c1421d4
https://pubmed.ncbi.nlm.nih.gov/7265112

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