Výsledky vyhledávání - "H.-D. Stachel"

Azagrevellins, Part I. Grevellin analogs with affinity to the N-methyl-D-aspartate (glycine site) receptor, a novel lead structure

Autor: H, Poschenrieder, G, Höfner, H D, Stachel

Publikováno v: Archiv der Pharmazie. 333(7)

A series of piperidine-2,3,5-triones (azagrevellins) has been prepared. A new synthesis has been introduced using the rearrangement of spiroepoxides in the presence of triethyloxonium tetrafluoroborate. The binding affinity toward the N-methyl-D-aspa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ec54398f8e5ce834f7ea430feb0bdf5
https://pubmed.ncbi.nlm.nih.gov/10965595

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Pyrrolidine-2,4-diones with affinity to the N-methyl-D-aspartate (glycine site) receptor, Part II. 5-Arylidene-pyrrolidine-2,3,4-trione 3-oximes as NMDA receptor antagonists

Autor: H, Poschenrieder, G, Höfner, H D, Stachel

Publikováno v: Archiv der Pharmazie. 332(9)

A series of oximes deriving from 5-arylidene-pyrrolidine-2,3,4-triones and pyridine-2,3,4-triones has been prepared. The presence of the tautomeric nitrosoenol was proven in solutions of alpha-ketooxime 7a. The binding affinity of the new oximes towa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67f95ff447d5e6ccac2474fc70507c16
https://pubmed.ncbi.nlm.nih.gov/10520300

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Fused 1,2-dithioles, V: Carbenoid anions as intermediates in reactions of pyrrothines and their heteroanalogues

Autor: J E, Schachtner, J, Nienaber, H D, Stachel, K, Waisser

Publikováno v: Die Pharmazie. 54(5)

Pyrrothines like thiolutine and other bicyclic 1,2-dithioles of type 1 when unsubstituted in 3-position are marked by their CH acidity. In the presence of weak bases such as triethylamine the pyrrothine 4 degraded via its anion to a thioketene trappe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c3c57b45fe36c71600304c3a8fdde64
https://pubmed.ncbi.nlm.nih.gov/10368826

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5-Arylidene-3-aryl-pyrrolidine-2,4-diones with affinity to the N-methyl-D-aspartate (glycine site) receptor, Part I

Autor: H, Poschenrieder, G, Höfner, H D, Stachel

Publikováno v: Archiv der Pharmazie. 331(12)

A series of new 5-arylidene 3-aryl-pyrrolidine-2,4-diones has been prepared. Their binding affinity toward the N-methyl-D-aspartate (glycine site) receptor has been measured as a basis for more detailed structure-activity relationship studies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e23a9de72f4046edb9cd83e852b899e
https://pubmed.ncbi.nlm.nih.gov/9923194

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