Výsledky vyhledávání - "H. van der Horst"

Akademický článek

VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

Autor: Thomas Thisted, F. Donelson Smith, Arnab Mukherjee, Yuliya Kleschenko, Feng Feng, Zhi-Gang Jiang, Timothy Eitas, Kanam Malhotra, Zuzana Biesova, Adejumoke Onumajuru, Faith Finley, Anokhi Cifuentes, Guolin Zhang, Gaëlle H. Martin, Yoshiko Takeuchi, Kader Thiam, Robert D. Schreiber, Edward H. van der Horst

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer immunotherapy. However, its effective targeting has been impeded by issues such as rapid clearance and cytokine release syndrome observed with previous VIST

Externí odkaz: https://doaj.org/article/5baa81963d6e484cb872b3eac39edd59

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Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

Autor: Gaëlle H. Martin, Alexis Gonon, Perrine Martin-Jeantet, Florence Renart-Depontieu, Zuzana Biesova, Anokhi Cifuentes, Arnab Mukherjee, Thomas Thisted, Astrid Doerner, Dean O. Campbell, Ludovic Bourré, Edward H. van der Horst, Amélie Rezza, Kader Thiam

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

ObjectivesDespite their efficacy, some immunotherapies have been shown to induce immune-related adverse events, including the potentially life-threatening cytokine release syndrome (CRS), calling for reliable and translational preclinical models to p

Externí odkaz: https://doaj.org/article/f1b517b31b7b45c781d7edf8fa9804ce

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Akademický článek

NOG EENS DE GEMEENTE-ACCOUNTANT EN ZIJN VERSLAG

Autor: H. Van Der Horst

Publikováno v: MAB, Vol 44, Iss 2, Pp 58-69 (1970)

Externí odkaz: https://doaj.org/article/40793f40453d42d7a9d4271d0b5b5ee9

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Akademický článek

Conditionally Active, pH-Sensitive Immunoregulatory Antibodies Targeting VISTA and CTLA-4 Lead an Emerging Class of Cancer Therapeutics

Autor: F. Donelson Smith, Robert H. Pierce, Thomas Thisted, Edward H. van der Horst

Publikováno v: Antibodies, Vol 12, Iss 3, p 55 (2023)

Immune checkpoints and other immunoregulatory targets can be difficult to precisely target due to expression on non-tumor immune cells critical to maintaining immune homeostasis in healthy tissues. On-target/off-tumor binding of therapeutics results

Externí odkaz: https://doaj.org/article/0e0955ff91804c98a568f65c79a9c7e1

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Combination of ZEN-3694 with CDK4/6 inhibitors reverses acquired resistance to CDK4/6 inhibitors in ER-positive breast cancer

Autor: Edward H. van der Horst, Reena G. Patel, Olesya A. Kharenko, Cyrus Calosing

Publikováno v: Cancer Gene Therapy. 29:859-869

CDK4/6 inhibitors significantly prolong progression-free survival in patients with advanced hormone receptor-positive (HR+) HER2-negative breast cancer. Despite recent successes, patients acquire resistance, necessitating the development of additiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b582f53dc9b948ac194b471518fa436
https://doi.org/10.1038/s41417-021-00375-9

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Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2

Autor: Emily M. Gesner, Sarah Attwell, Henrik C. Hansen, Alexandre Gagnon, Olesya A. Kharenko, Edward H. van der Horst, Léa Mélin

Publikováno v: ACS Omega, Vol 6, Iss 33, Pp 21327-21338 (2021)
ACS Omega

PB1 is a bromodomain-containing protein hypothesized to act as the nucleosome-recognition subunit of the PBAF complex. Although PB1 is a key component of the PBAF chromatin remodeling complex, its exact role has not been elucidated due to the lack of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bbdc2b24b9594bf06b687e6a6745e2
https://doaj.org/article/2ac6ac4ea775409387e171e7e5b01be8

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Abstract 4645: Identification of conditionally active antibodies that selectively block CD39 activity in the acidic tumor microenvironment

Autor: Aiping Bai, Elise Renahan, Kanam Malhotra, Thomas Thisted, F. Donelson Smith, Robert H Pierce, Edward H van der Horst

Publikováno v: Cancer Research. 83:4645-4645

Background CD39 expression is upregulated in the tumor microenvironment (TME), which is characterized by high levels of extracellular ATP (eATP) and low pH. CD39 catalyzes the rate-limiting degradation step of this immunostimulatory ATP, leading to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd7a34b58f3681343605a6f48eb49954
https://doi.org/10.1158/1538-7445.am2023-4645

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