Zobrazeno 1 - 10 of 56 pro vyhledávání: '"H. van Ooijen"'
1
Akademický článek
FOXO transcriptional activity is associated with response to chemoradiation in EAC
Autor: A. Creemers, A. P. van der Zalm, A. van de Stolpe, L. Holtzer, M. Stoffels, G. K. J. Hooijer, E. A. Ebbing, H. van Ooijen, A. G. C. van Brussel, E. M. G. Aussems-Custers, M. I. van Berge Henegouwen, M. C. C. M. Hulshof, J. J. G. H. M. Bergman, S. L. Meijer, M. F. Bijlsma, H. W. M. van Laarhoven
Publikováno v: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract In this study we aimed to investigate signaling pathways that drive therapy resistance in esophageal adenocarcinoma (EAC). Paraffin-embedded material was analyzed in two patient cohorts: (i) 236 EAC patients with a primary tumor biopsy and c
Externí odkaz: https://doaj.org/article/b796bd80452e4486bd3a67a7544d6df4
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2
Akademický článek
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3
Akademický článek
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5
Abstract P5-11-06: Does hormone expression by IHC predict ER pathway activity? An analysis in a metastatic breast cancer patient cohort
Autor: H. van Ooijen, A. van Brussel, F Beca, KH Allison, Daniel L. Rubin, Alfiia Galimzianova, DM Cohn, S.S. Yang, A. van de Stolpe
Publikováno v: Cancer Research. 79:P5-11
Background: Immunohistochemistry (IHC) staining for ER and progesterone (PR) receptors in breast cancer tissue is the current standard for testing for eligibility for hormone targeted therapies. However, these markers are imperfect predictors of resp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97cb571992aa64b65748460592806ff8
https://doi.org/10.1158/1538-7445.sabcs18-p5-11-06
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6
Abstract P2-09-34: An mRNA-based method to measure PI3K activity in cancer tissue using a computational pathway model to assess FOXO transcriptional activity
Autor: C Dam, M Dou, Marten Hornsveld, A. van de Stolpe, Wim Verhaegh, H. van Ooijen, Boudewijn M.T. Burgering, A Eijkelenboom, Rick Velter
Publikováno v: Cancer Research. 78:P2-09
Introduction The PI3K signaling pathway is frequently active in breast cancer, and therapeutic inhibitors have been developed. However, it has proven difficult to correctly predict treatment response. We developed a method that measures functional ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5eb9e33ada8eec983c3c70a22b58b499
https://doi.org/10.1158/1538-7445.sabcs17-p2-09-34
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9
Exploring candidate signal transduction pathways for targeted therapy in esophageal cancer
Autor: H. van Ooijen, Maarten F. Bijlsma, Laurent Holtzer, E.M.G. Aussems-Custers, M. Stoffels, M. I. van Berge Henegouwen, H.W.M. van Laarhoven, A. van Brussel, Sheila K. Krishnadath, Aafke Creemers, Maarten C.C.M. Hulshof, A. van de Stolpe, Sybren L. Meijer
Publikováno v: Annals of Oncology. 30:v316
Background To reveal candidate signaling pathways for targeted therapy in esophageal cancer (EC), and esophageal adenocarcinoma (EAC) in particular, we investigated key signal transduction pathways in material available in clinical routine, before an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60d0e2a86761dc9b139db5f2eec8d2c8
https://doi.org/10.1093/annonc/mdz247.150
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