Phosphodiesterase inhibition by new cardiotonic agents: Mechanism of action and possible clinical relevance in the therapy of congestive heart failure

Autor: H. v. der Leyen

Publikováno v: Klinische Wochenschrift. 67:605-615

Cyclic AMP is known as a secondary messenger regulating the myocardial force of contraction. For the degradation of cAMP multiple forms of PDE within the cell are described, which vary according to substrate specificity, kinetic characterization, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19be4583a42c02264964ca97d5c96316
https://doi.org/10.1007/bf01718141

Basal and isoprenaline-stimulated cAMP content in failing versus nonfailing human cardiac preparations

Autor: Volker Döring, Birgitt Stein, Wilhelm Schmitz, Peter Kalmár, W. Danielsen, Jutta Starbatty, W Meyer, H. Scholz, Joachim Neumann, H. v. Der Leyen

Publikováno v: Journal of cardiovascular pharmacology. 14(1)

We measured force of contraction and cAMP content in human isolated electrically driven right ventricular trabeculae carneae with and without the addition of isoprenaline (0.2 microM). Basal cAMP content was approximately 200% higher in preparations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a7c4ad9865be2b273bea345db10ec7
https://pubmed.ncbi.nlm.nih.gov/2475709

Design, Synthesis, Anti-Cancer, Anti-Inflammatory and In Silico Studies of 3-Substituted-2-Oxindole Derivatives.

Autor: Hublikar M; Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, Maharashtra, 413255, India., Kadu V; Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, Maharashtra, 413255, India., Edake N; Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, Maharashtra, 413255, India., Raut D; Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, Maharashtra, 413255, India., Shirame S; Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, Maharashtra, 413255, India., Ahmed MZ; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia., Makam P; Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University, Arcadia Grant, P.O. Chandanwari, Premnagar, Dehradun, Uttarakhand, 248007, India., Ahmad MS; Bioinformatics Centre, Savitribai Phule Pune University, Pune, Maharashtra, 248007, India., Meshram RJ; Bioinformatics Centre, Savitribai Phule Pune University, Pune, Maharashtra, 248007, India., Bhosale R; Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, Maharashtra, 413255, India.

Publikováno v: Chemistry & biodiversity [Chem Biodivers] 2024 Nov; Vol. 21 (11), pp. e202400844. Date of Electronic Publication: 2024 Sep 24.

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Phosphodiesterase inhibition by new cardiotonic agents: Mechanism of action and possible clinical relevance in the therapy of congestive heart failure.

Autor: Leyen, H.

Publikováno v: Klinische Wochenschrift; Jun1989, Vol. 67 Issue 12, p605-615, 11p