Zobrazeno 1 - 10 of 42 pro vyhledávání: '"H. Zeugner"'
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Unexpected opioid activity in a known class of drug
Autor: Trevor J. Petcher, W. Benson, E. Finner, Richard Maurer, Dietmar Römer, H. Zeugner, Heinz H. Büscher, Ronald C. Hill, P. W. Thies, W. Milkowski
Publikováno v: Life Sciences. 31:1217-1220
Tifluadom, although structurally a 1,4 benzodiazepine, has no affinity for the 3H-flunitrazepam binding site, but is a potent displacer of 3H-bremazocine from its opioid binding site. Tifluadom is characterised as an opiate kappa-receptor agonist in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a347cdf687c87f46eec313604989193
https://doi.org/10.1016/0024-3205(82)90346-0
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3
Structures of tifluadom [5-(2-fluorophenyl)-1-methyl-2-(3-thenoylaminomethyl)-2,3-dihydro-1H-1,4-benzodiazepine] hydrochloride, C22H21FN3OS+.Cl−, and of (+)-tifluadom p-toluenesulphonate, C22H21FN3OS+.C7H7O3S−, and the absolute configuration of the latter
Autor: H. Zeugner, T. J. Petcher, U. Maetzel, A. Widmer
Publikováno v: Acta Crystallographica Section C Crystal Structure Communications. 41:909-912
C 22 H 21 FN 3 OS + •Cl − cristallise dans P2 1 2 1 2 1 avec Z=4, affinement jusqu'a R=0,051. (+)-C 22 H 21 FN 3 OS + •C 7 H 7 O 3 S − cristallise dans P2 1 2 1 2 1 avec Z=4; affinement jusqu'a R=0,041. Configuration absolue 2S. Dans les deux
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be32942e1a2bc6a9f8e905799d660fbb
https://doi.org/10.1107/s0108270185005960
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4
Metabolism and pharmacokinetics of metaclazepam (Talis®), Part III: Determination of the chemical structure of metabolites in dogs, rabbits and men
Autor: H. Zeugner, F. Borchers, H. J. Hausleiter, G. Achtert
Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 9:325-346
The metabolism of 7-bromo-1-methyl-2-methoxymethyl-5-(2'-chlorophenyl)-2, 3-dihydro-1H-1,4-benzodiazepine (metaclazepam, Talis) in animals and men is described. Based upon mass spectrometry fifteen metabolites could be identified. Qualitative and qua
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae661ce5b697aa78e68887b75c72c97b
https://doi.org/10.1007/bf03189684
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5
Effects of the opioid benzodiazepine tifluadom and its optical isomers on spontaneous locomotor activity of mice
Autor: H. Zeugner, M. Ruhland
Publikováno v: Life Sciences. 33:631-634
The opioid benzodiazepine tifluadom and its (+) and (-) enantiomers affect locomotor activity of mice with patterns different from those of diazepam or the prototype opioids morphine (mu) or bremazocine (kappa). Lacking the initial locomotor inhibiti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac75fd233c6440a4a65e731fe40c306c
https://doi.org/10.1016/0024-3205(83)90582-9
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9
The kappa opioid receptor and food intake
Autor: H. Zeugner, John E. Morley, Allen S. Levine, J. Kneip, Martha K. Grace, G.T. Shearman
Publikováno v: European journal of pharmacology. 112(1)
Many studies have suggested a role of opioid receptors in the modulation of food intake. Several distinct classes of opioid receptors have been postulated. In an attempt to establish which opioid receptor(s) modulate feeding we studied the effect of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bfb5a717dba0709cfd27dae07d205e
https://pubmed.ncbi.nlm.nih.gov/2990965
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