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Akademický článek

Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its role in response to therapy is lacking.

Externí odkaz: https://doaj.org/article/3a27bc68fbda40dca2027e7c95c28684

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Akademický článek

POLQ inhibition elicits an immune response in homologous recombination–deficient pancreatic adenocarcinoma via cGAS/STING signaling

Autor: Grace Oh, Annie Wang, Lidong Wang, Jiufeng Li, Gregor Werba, Daniel Weissinger, Ende Zhao, Surajit Dhara, Rosmel E. Hernandez, Amanda Ackermann, Sarina Porcella, Despoina Kalfakakou, Igor Dolgalev, Emily Kawaler, Talia Golan, Theodore H. Welling, Agnel Sfeir, Diane M. Simeone

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors mutations in homologous recombination–repair (HR-repair) proteins in 20%–25% of cases. Defects in HR impart a specific vulnerability to poly ADP ribose polymerase

Externí odkaz: https://doaj.org/article/9914b8b0574846e7832524ad7f4fa02e

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Akademický článek

Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies

Autor: Shanshan Wan, Ende Zhao, Daniel Freeman, Daniel Weissinger, Benjamin A. Krantz, Gregor Werba, Lauren G. Khanna, Despina Siolas, Paul E. Oberstein, Pratip K. Chattopadhyay, Diane M. Simeone, Theodore H. Welling

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Hepato-pancreatico-biliary (HPB) malignancies are difficult-to-treat and continue to to have a high mortality and significant therapeutic resistance to standard therapies. Immune oncology (IO) therapies have demonstrated efficacy in several solid mal

Externí odkaz: https://doaj.org/article/53dc33a9909e44bcaef5e0e3ab99ac19

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Akademický článek

Tumor‐Selective Altered Glycosylation and Functional Attenuation of CD73 in Human Hepatocellular Carcinoma

Autor: Karel P. Alcedo, Andres Guerrero, Venkatesha Basrur, Dong Fu, Monea L. Richardson, Joshua S. McLane, Chih‐Chiang Tsou, Alexey I. Nesvizhskii, Theodore H. Welling, Carlito B. Lebrilla, Carol A. Otey, Hong Jin Kim, M. Bishr Omary, Natasha T. Snider

Publikováno v: Hepatology Communications, Vol 3, Iss 10, Pp 1400-1414 (2019)

CD73, a cell‐surface N‐linked glycoprotein that produces extracellular adenosine, is a novel target for cancer immunotherapy. Although anti‐CD73 antibodies have entered clinical development, CD73 has both protumor and antitumor functions, depen

Externí odkaz: https://doaj.org/article/550bf2b9b1d9441695df8b5476ab00f0

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Data from CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in Mice

Autor: Marina Pasca di Magliano, Robert H. Vonderheide, Theodore H. Welling, Rebecca A. Evans, Meredith A. Collins, Shanshan Wan, Filip Bednar, Esha Mathew, Wei Yan, Yaqing Zhang

Pancreatic cancer, one of the deadliest human malignancies, is associated with oncogenic Kras and is most commonly preceded by precursor lesions known as pancreatic intraepithelial neoplasias (PanIN). PanIN formation is accompanied by the establishme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77987c6afc3695ff044a5d3af9bc4ccb
https://doi.org/10.1158/2326-6066.c.6548512.v1

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