Výsledky vyhledávání - "H. V. Malling"

Acrylamide exposure induces a delayed unscheduled dna synthesis in germ cells of male mice that is correlated with the temporal pattern of adduct formation in testis DNA

Autor: Gary A. Sega, Estela E. Generoso, Patricia A. Brimer, H. V. Malling

Publikováno v: Environmental and Molecular Mutagenesis. 16:137-142

A study of meiotic and postmeiotic germ-cell-stage sensitivity of male mice to induction of unscheduled DNA synthesis (UDS) by acrylamide showed that DNA repair could be detected in early spermatocytes (after the last scheduled DNA synthesis) through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bffcd722a1798942fbdaa6366f92792
https://doi.org/10.1002/em.2850160302

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Quantitative estimation of the genetic risk associated with the induction of heritable translocations at low-dose exposure: Ethylene oxide as an example

Autor: Vicki L. Dellarco, David Jacobson-Kram, H. V. Malling, Kerry L. Dearfield, Lorenz Rhomberg, Cheryl Siegel-Scott

Publikováno v: Environmental and Molecular Mutagenesis. 16:104-125

This paper explores how quantitative risk assessment methods might be extended to analysis of risks to the human germ line. High inhalation exposures to ethylene oxide are reported to cause heritable translocations in male mice with a steep and nonli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b390ddd598ff51a0f174b5ef3dd19ed
https://doi.org/10.1002/em.2850160208

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A Toxicity Evaluation and Predictive System Based on Neural Networks and Wavelets

Autor: P. L. Piotrowski, B. G. Sumpter, H. V. Malling, J. S. Wassom, P. Y. Lu, R. A. Brothers, G. A. Sega, S. A. Martin, M. Parang

Publikováno v: ChemInform. 38

A computational approach has been developed for performing efficient and reasonably accurate toxicity evaluation and prediction. The approach is based on computational neural networks linked to modern computational chemistry and wavelet methods. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8457683af7e5ddb7c59ca5dbf224925
https://doi.org/10.1002/chin.200725205

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Estimation of the average burst size of Phix174 am3, cs70 for use in mutation assays with transgenic mice

Autor: R R, Delongchamp, C R, Valentine, H V, Malling

Publikováno v: Environmental and molecular mutagenesis. 37(4)

In mutation assays using transgenic mice, with recoverable vectors such as PhiX174 am3, cs70, mutations originate from two sources: (1) in vivo mutations, that is, mutations that were fixed in the mouse, or (2) ex vivo mutations, that is, mutations t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::564946db761a7d903fad0cfce24522b0
https://pubmed.ncbi.nlm.nih.gov/11424186

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Mutagenesis of a single AT basepair in mice transgenic for PhiX174 am3, cs70. II. Brain

Autor: H V, Malling, R R, Newbold, S, Lewis, L, Barnett, R P, Weaver

Publikováno v: Mutation research. 444(1)

Most cell divisions in the mouse brain have ceased by 14 days after birth. Therefore, spontaneous mutations that occur in brain cells can be assumed to be fixed by replication during brain development. Spontaneous and ethylnitrosourea (ENU)-induced r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3aea95ffc337cb9cbb80b9911cf992d
https://pubmed.ncbi.nlm.nih.gov/10477342

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Akademický článek

A Toxicity Evaluation and Predictive System Based on Neural Networks and Wavelets.

Autor: P. L. Piotrowski, B. G. Sumpter, H. V. Malling, J. S. Wassom, P. Y. Lu, R. A. Brothers, G. A. Sega, S. A. Martin, M. Parang

Publikováno v: Journal of Chemical Information & Modeling; Mar2007, Vol. 47 Issue 2, p676-685, 10p

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Storage of spheroplasts at −70°C for transfection with φX174 RFDNA

Autor: M. C. Fater, Stephen C. Hardies, H. V. Malling, Clyde A. Hutchison, Marshall H. Edgell, J. G. Burkhart

Publikováno v: Gene Analysis Techniques. 4:23-26

A method was developed for preparation of spheroplasts used for transfection with phi X174 RF DNA. This method had a high-level competence and retained the competence for up to one year of storage in 7% DMSO at -70 degrees C.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc565f1c194558c2408b4f4cb2082f27
https://doi.org/10.1016/0735-0651(87)90014-8

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Sperm abnormalities in the PL/J mouse strain: A description and proposed mechanism for malformation

Autor: J. G. Burkhart, H. V. Malling

Publikováno v: Gamete Research. 4:171-183

A high frequency (42%) of sperm from the inbred homozygous mouse strain PL/J are abnormal. Head shape abnormalities occur in 15% of the total sperm; and 27% of the sperm are headless, with the mitochondria condensed into a mass at the caudal end of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4582c60e349ace3dce216530cda1a659
https://doi.org/10.1002/mrd.1120040302

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