Výsledky vyhledávání - "H. U. Bryant"

Clomiphene Prevents Cancellous Bone Loss from Tibia of Ovariectomized Rats

Autor: D. E. Magee, Russell T. Turner, H. U. Bryant, M. A. Jimenez

Publikováno v: Endocrinology. 138:1794-1800

Estrogen inhibits postmenopausal bone loss and decreases fracture risk. Unfortunately, estrogen replacement therapy has many undesirable side effects, the majority of which are due to stimulation of reproductive tissues. Tissue specific estrogen agon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a552337329f6ce57019f102dd31727b4
https://doi.org/10.1210/endo.138.5.5109

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Raloxifene preserves bone strength and bone mass in ovariectomized rats

Autor: H U Bryant, Masahiko Sato, Charles H. Turner

Publikováno v: Endocrinology. 135:2001-2005

We investigated the effects of raloxifene, a nonsteroidal benzothiophene, on bone strength in ovariectomized rats and compared them with estrogen treatment. Sixty ovariectomized Sprague-Dawley rats were divided into three groups for treatment with or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a4a345caece93fc567a867f2b02a10
https://doi.org/10.1210/endo.135.5.7956922

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The effects of raloxifene on tibia histomorphometry in ovariectomized rats

Autor: Masahiko Sato, D. E. Magee, Glenda L. Evans, Russell T. Turner, H. U. Bryant

Publikováno v: Endocrinology. 134:2283-2288

Tissue-specific estrogen agonists may be useful in protecting against osteoporosis and the increased risk of coronary heart disease in postmenopausal women with minimal undesired effects on reproductive tissues. The actions of the mixed estrogen agon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32dfe09c061517c0dd3ed7b078205e85
https://doi.org/10.1210/endo.134.5.8156931

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Inhibition of glycinamide ribonucleotide formyltransferase results in selective inhibition of macrophage cytokine secretion in vitro and in vivo efficacy in rat adjuvant arthritis

Autor: S, Chintalacharuvu, G F, Evans, C, Shih, H U, Bryant, G E, Sandusky, S H, Zuckerman

Publikováno v: Clinical and experimental rheumatology. 23(4)

To determine the effects of a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor on macrophage inflammatory processes and in vivo in rat adjuvant arthritis.GARFT inhibitors, LY309886 (6S-2',5'-thienyl-5, 10-dideazatetrahydrofolic acid) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d07bc409407397cc50c6d7e742299bea
https://pubmed.ncbi.nlm.nih.gov/16095109

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Selective estrogen receptor modulators: tissue selectivity and differential uterine effects

Autor: Sheryl L. Silfen, Angelina V. Ciaccia, H. U. Bryant

Publikováno v: Climacteric : the journal of the International Menopause Society. 2(4)

Selective estrogen receptor modulators (SERMs) are compounds that bind to estrogen receptors and produce estrogen-like (agonist) effects in some tissues and estrogen-blocking (antagonist) effects in other tissues. One of the goals of SERM research ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3e02b631fcd30d5043ebd6554a73e3
https://pubmed.ncbi.nlm.nih.gov/11910661

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Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer

Autor: N, Suh, A L, Glasebrook, A D, Palkowitz, H U, Bryant, L L, Burris, J J, Starling, H L, Pearce, C, Williams, C, Peer, Y, Wang, M B, Sporn

Publikováno v: Cancer research. 61(23)

Arzoxifene ([6-hydroxy-3-[4-[2-(1-piperidinyl)-ethoxy]phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene) is a selective estrogen receptor modulator (SERM) that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen ago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24086254f36ab915ef7a017b0e76a352
https://pubmed.ncbi.nlm.nih.gov/11731420

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Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulation

Autor: H U, Bryant

Publikováno v: Reviews in endocrinemetabolic disorders. 2(1)

Raloxifene possesses a complex pharmacology with tissue-selective estrogen agonist and antagonist effects. At the center of these effects resides the high affinity interaction of raloxifene with the ER. The ability of raloxifene to compete with estro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5de7a3fba691e02d825048746e27510
https://pubmed.ncbi.nlm.nih.gov/11704975

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The effect of raloxifene on coronary arteries in aged ovariectomized ewes

Autor: Robert H. Wrigley, Craig H. Selzman, H. U. Bryant, L. Kaufman, C. Mallinckrodt, Thomas A. Whitehill, Denise Parker, J S Gaynor, Eric Monnet, A. S. Turner

Publikováno v: ResearcherID

Background – Ovariectomized sheep are a useful model of postmenopausal osteoporosis and other postmenopausal conditions. Estrogen may have a protective effect on the coronary arteries in postmenopausal women. The effects of raloxifene, a selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7352865967e959b13f9c9ff4e7d9d81e
https://pubmed.ncbi.nlm.nih.gov/11110106

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Mechanism of action of estrogens and selective estrogen receptor modulators

Autor: V, Krishnan, H, Heath, H U, Bryant

Publikováno v: Vitamins and hormones. 60

Estrogen, one of several sex steroid hormones, mediates its actions through the estrogen receptor. The estrogen receptor (ER) has two subtypes, ER alpha and ER beta, each of which predominates in specific tissues and organs. Cofactor proteins interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::327d73561d1770444d5af8beb6c3af3d
https://pubmed.ncbi.nlm.nih.gov/11037623

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