Zobrazeno 1 - 10
of 205
pro vyhledávání: '"H. Thygesen"'
Publikováno v:
JMIR Mental Health, Vol 11, p e57400 (2024)
BackgroundLarge language models (LLMs) are advanced artificial neural networks trained on extensive datasets to accurately understand and generate natural language. While they have received much attention and demonstrated potential in digital health,
Externí odkaz:
https://doaj.org/article/7ad362e59799406ab0abc4658b279972
Autor:
Marta Pineda-Moncusí, Freya Allery, Antonella Delmestri, Thomas Bolton, John Nolan, Johan H. Thygesen, Alex Handy, Amitava Banerjee, Spiros Denaxas, Christopher Tomlinson, Alastair K. Denniston, Cathie Sudlow, Ashley Akbari, Angela Wood, Gary S. Collins, Irene Petersen, Laura C. Coates, Kamlesh Khunti, Daniel Prieto-sAlhambra, Sara Khalid, on behalf of the CVD-COVID-UK/COVID-IMPACT Consortium
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-14 (2024)
Abstract Intersectional social determinants including ethnicity are vital in health research. We curated a population-wide data resource of self-identified ethnicity data from over 60 million individuals in England primary care, linking it to hospita
Externí odkaz:
https://doaj.org/article/aad80e4d6c824d3a8dd8964aaf8bdee5
Autor:
Huayu Zhang, Johan H. Thygesen, Ting Shi, Georgios V. Gkoutos, Harry Hemingway, Bruce Guthrie, Honghan Wu, Genomics England Research Consortium
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-7 (2022)
Abstract Background Several common conditions have been widely recognised as risk factors for COVID-19 related death, but risks borne by people with rare diseases are largely unknown. Therefore, we aim to estimate the difference of risk for people wi
Externí odkaz:
https://doaj.org/article/4fcf3183b1fb485e893d991f336c48ed
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237664 (2020)
BackgroundMental health supported housing services are a key component in the rehabilitation of people with severe and complex needs. They are implemented widely in the UK and other deinstitutionalised countries but there have been few empirical stud
Externí odkaz:
https://doaj.org/article/39af6ebacfee42c3b5dc565306f34d10
Autor:
Valerie Speirs, Abeer M. Shaaban, Lucy F. Stead, Davide Melisi, Marie-Louise Fjällskog, Ingrid A. Hedenfalk, Maria G. Daidone, Vera Cappelletti, Helene H. Thygesen, Margaret Jeffery, Ian O. Ellis, Janina Kulka, Rosemary A. Walker, Mark Stephens, Sami Shousha, Elena Provenzano, Marcella Mottolese, Anna Di Benedetto, Maria Litwiniuk, Rani Kanthan, J. Louise Jones, Lee B. Jordan, Laura Fulford, Jo Dent, Gabor Cserni, Hedieh Honarpisheh, Cecilia Nilsson, Carmine Carbone, Charlotte A.B. Suleman, Alastair Droop, Sreekumar Sundara Rajan, Matthew P. Humphries
Interrogation of Oncomine{trade mark, serif} (https://www.oncomine.org/) showed higher expression of eIF4E and eIF5 in breast (top panel) and lung cancer (bottom panel) compared to normal tissue. When these biomarkers were compared for gender, eIF4E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cde27b41ba08b5a7ceab6f3d713b07e
https://doi.org/10.1158/1078-0432.22466838
https://doi.org/10.1158/1078-0432.22466838
Autor:
Valerie Speirs, Abeer M. Shaaban, Lucy F. Stead, Davide Melisi, Marie-Louise Fjällskog, Ingrid A. Hedenfalk, Maria G. Daidone, Vera Cappelletti, Helene H. Thygesen, Margaret Jeffery, Ian O. Ellis, Janina Kulka, Rosemary A. Walker, Mark Stephens, Sami Shousha, Elena Provenzano, Marcella Mottolese, Anna Di Benedetto, Maria Litwiniuk, Rani Kanthan, J. Louise Jones, Lee B. Jordan, Laura Fulford, Jo Dent, Gabor Cserni, Hedieh Honarpisheh, Cecilia Nilsson, Carmine Carbone, Charlotte A.B. Suleman, Alastair Droop, Sreekumar Sundara Rajan, Matthew P. Humphries
Purpose: Breast cancer affects both genders, but is understudied in men. Although still rare, male breast cancer (MBC) is being diagnosed more frequently. Treatments are wholly informed by clinical studies conducted in women, based on assumptions tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174b3ffbad5c34c993f0cf995b181a98
https://doi.org/10.1158/1078-0432.c.6526449.v1
https://doi.org/10.1158/1078-0432.c.6526449.v1
Autor:
Valerie Speirs, Abeer M. Shaaban, Lucy F. Stead, Davide Melisi, Marie-Louise Fjällskog, Ingrid A. Hedenfalk, Maria G. Daidone, Vera Cappelletti, Helene H. Thygesen, Margaret Jeffery, Ian O. Ellis, Janina Kulka, Rosemary A. Walker, Mark Stephens, Sami Shousha, Elena Provenzano, Marcella Mottolese, Anna Di Benedetto, Maria Litwiniuk, Rani Kanthan, J. Louise Jones, Lee B. Jordan, Laura Fulford, Jo Dent, Gabor Cserni, Hedieh Honarpisheh, Cecilia Nilsson, Carmine Carbone, Charlotte A.B. Suleman, Alastair Droop, Sreekumar Sundara Rajan, Matthew P. Humphries
R.O.C curve analysis was used to determine the cut-off value for each antibody to determine a point of dichotomisation (graphs). Gradation of intensity of immunohistochemical staining (weak, moderate, strong) for eIF1 (A), eIF2 (B), eIF4E (C) and eIF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26628342bc42860adca5c57fc108a54d
https://doi.org/10.1158/1078-0432.22466844
https://doi.org/10.1158/1078-0432.22466844
Autor:
Valerie Speirs, Abeer M. Shaaban, Lucy F. Stead, Davide Melisi, Marie-Louise Fjällskog, Ingrid A. Hedenfalk, Maria G. Daidone, Vera Cappelletti, Helene H. Thygesen, Margaret Jeffery, Ian O. Ellis, Janina Kulka, Rosemary A. Walker, Mark Stephens, Sami Shousha, Elena Provenzano, Marcella Mottolese, Anna Di Benedetto, Maria Litwiniuk, Rani Kanthan, J. Louise Jones, Lee B. Jordan, Laura Fulford, Jo Dent, Gabor Cserni, Hedieh Honarpisheh, Cecilia Nilsson, Carmine Carbone, Charlotte A.B. Suleman, Alastair Droop, Sreekumar Sundara Rajan, Matthew P. Humphries
Details of the male breast cancer samples used at different stages of the experimental workflow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1454963a0a014fc675994f0510f55a89
https://doi.org/10.1158/1078-0432.22466841
https://doi.org/10.1158/1078-0432.22466841
Autor:
Valerie Speirs, Abeer M. Shaaban, Lucy F. Stead, Davide Melisi, Marie-Louise Fjällskog, Ingrid A. Hedenfalk, Maria G. Daidone, Vera Cappelletti, Helene H. Thygesen, Margaret Jeffery, Ian O. Ellis, Janina Kulka, Rosemary A. Walker, Mark Stephens, Sami Shousha, Elena Provenzano, Marcella Mottolese, Anna Di Benedetto, Maria Litwiniuk, Rani Kanthan, J. Louise Jones, Lee B. Jordan, Laura Fulford, Jo Dent, Gabor Cserni, Hedieh Honarpisheh, Cecilia Nilsson, Carmine Carbone, Charlotte A.B. Suleman, Alastair Droop, Sreekumar Sundara Rajan, Matthew P. Humphries
Relationship between eIF4E, eIF5 and clinico-pathological parameters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4359044ef6e135fb9e3da71313c162a1
https://doi.org/10.1158/1078-0432.22466835.v1
https://doi.org/10.1158/1078-0432.22466835.v1
Autor:
Ruud van Winkel, Eugenia Kravariti, Matthias Weisbrod, Jim van Os, Bart P. F. Rutten, Lieuwe de Haan, Vaughan Bell, Behrooz Z. Alizadeh, Katja Schulze, Benedicto Crespo-Facorro, Claudia J. P. Simons, Jurjen J. Luykx, Assen Jablensky, Wiepke Cahn, Conrad Iyegbe, Frederike Schirmbeck, Elvira Bramon, John Powell, Jasmine Harju-Seppänen, Jeremy Hall, Rebecca M. Jones, René S. Kahn, Robin M. Murray, Luba Kalaydjieva, Dan Rujescu, Sonja M C de Zwarte, Marco Picchioni, Johan H. Thygesen, Roel A. Ophoff, Anjali Bhat, Therese van Amelsvoort, Timothea Toulopoulou, Siri Ranlund, Rebecca Muir, Kuang Lin, Diana Prata, Mei-Hua Hall, Ignacio Mata, Muriel Walshe, Stephen M. Lawrie, Karoline Kuchenbaecker, Madiha Shaikh, Eirini Zartaloudi, Isabelle Austin-Zimmerman, Evangelos Vassos, Richard Bruggeman, Agna A. Bartels-Velthuis, Andrew M. McIntosh, Haritz Irizar, Neeltje E.M. van Haren, Marta Di Forti, Andrew McQuillin, Alvaro Diez-Revuelta, Cathryn M. Lewis, Amelia Presman, Stella Calafato, Colm McDonald
Publikováno v:
Molecular Psychiatry, 26(9). Nature Publishing Group
Molecular psychiatry, 26(9), 5307-5319. Nature Publishing Group
Molecular Psychiatry, 26(9), 5307-5319. Nature Publishing Group
Molecular Psychiatry
Molecular Psychiatry, vol 26, iss 9
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Thygesen, J H, Presman, A, Harju-seppänen, J, Irizar, H, Jones, R, Kuchenbaecker, K, Lin, K, Alizadeh, B Z, Austin-zimmerman, I, Bartels-velthuis, A, Bhat, A, Bruggeman, R, Cahn, W, Calafato, S, Crespo-facorro, B, De Haan, L, De Zwarte, S M C, Di Forti, M, Díez-revuelta, Á, Hall, J, Hall, M, Iyegbe, C, Jablensky, A, Kahn, R, Kalaydjieva, L, Kravariti, E, Lawrie, S, Luykx, J J, Mata, I, Mcdonald, C, Mcintosh, A M, Mcquillin, A, Muir, R, Ophoff, R, Picchioni, M, Prata, D P, Ranlund, S, Rujescu, D, Rutten, B P F, Schulze, K, Shaikh, M, Schirmbeck, F, Simons, C J P, Toulopoulou, T, Van Amelsvoort, T, Van Haren, N, Van Os, J, Van Winkel, R, Vassos, E, Walshe, M, Weisbrod, M, Zartaloudi, E, Bell, V, Powell, J, Lewis, C M, Murray, R M & Bramon, E 2020, ' Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study ', Molecular Psychiatry . https://doi.org/10.1038/s41380-020-0820-7
Molecular psychiatry, 26(9), 5307-5319. Nature Publishing Group
Molecular Psychiatry, 26(9), 5307-5319. Nature Publishing Group
Molecular Psychiatry
Molecular Psychiatry, vol 26, iss 9
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Thygesen, J H, Presman, A, Harju-seppänen, J, Irizar, H, Jones, R, Kuchenbaecker, K, Lin, K, Alizadeh, B Z, Austin-zimmerman, I, Bartels-velthuis, A, Bhat, A, Bruggeman, R, Cahn, W, Calafato, S, Crespo-facorro, B, De Haan, L, De Zwarte, S M C, Di Forti, M, Díez-revuelta, Á, Hall, J, Hall, M, Iyegbe, C, Jablensky, A, Kahn, R, Kalaydjieva, L, Kravariti, E, Lawrie, S, Luykx, J J, Mata, I, Mcdonald, C, Mcintosh, A M, Mcquillin, A, Muir, R, Ophoff, R, Picchioni, M, Prata, D P, Ranlund, S, Rujescu, D, Rutten, B P F, Schulze, K, Shaikh, M, Schirmbeck, F, Simons, C J P, Toulopoulou, T, Van Amelsvoort, T, Van Haren, N, Van Os, J, Van Winkel, R, Vassos, E, Walshe, M, Weisbrod, M, Zartaloudi, E, Bell, V, Powell, J, Lewis, C M, Murray, R M & Bramon, E 2020, ' Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study ', Molecular Psychiatry . https://doi.org/10.1038/s41380-020-0820-7
The burden of large and rare copy number genetic variants (CNVs) as well as certain specific CNVs increase the risk of developing schizophrenia. Several cognitive measures are purported schizophrenia endophenotypes and may represent an intermediate p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77aa22bb723acca7995d821851a526a
https://pure.eur.nl/en/publications/2276c730-19ed-41bc-9ed2-7ef0ebac9832
https://pure.eur.nl/en/publications/2276c730-19ed-41bc-9ed2-7ef0ebac9832