Výsledky vyhledávání - "H. Terry Wepsic"

Autor: H. Terry Wepsic, Neil Hoa

Publikováno v: International Immunopharmacology. 114:109491

Paraptosis is the programmed cell death pathway that leads to cellular necrosis. Manystudies have shown that prolonged paraptosis activation improves tumorimmunogenicity; this treatment reproduces the vaccinating effects of mM-CSFtransduced cells. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ccefcc2ff0e5891f78f0b2ba5ac562d
https://doi.org/10.1016/j.intimp.2022.109491

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Human monocytes kill M-CSF-expressing glioma cells by BK channel activation

Autor: Neil Hoa, H. Terry Wepsic, Christina Delgado, Gerald Vandeusen, Patric M. Schiltz, Martin R. Jadus, Michael P. Myers, Linda L. Callahan, Jian Gang Zhang

Publikováno v: Laboratory Investigation. 87:115-129

In this study, human monocytes/macrophages were observed to kill human U251 glioma cells expressing membrane macrophage colony-stimulating factor (mM-CSF) via a swelling and vacuolization process called paraptosis. Human monocytes responded to the mM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c81716107cd8c433ddae73dc1dbe75c
https://doi.org/10.1038/labinvest.3700506

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Antigenic Profiling of Glioma Cells to Generate Allogeneic Vaccines or Dendritic Cell–Based Therapeutics

Autor: Neil Hoa, H. Terry Wepsic, Hideho Okada, Martin R. Jadus, Boris Minev, Junichi Eguchi, Wenxue Ma, Carol A. Kruse, Stephanie Schroter, Habib Fakhrai, Christina Delgado, Jian Gang Zhang, German G. Gomez

Publikováno v: Clinical Cancer Research. 13:566-575

Purpose: Allogeneic glioma cell lines that are partially matched to the patient at class I human leukocyte antigen (HLA) loci and that display tumor-associated antigens (TAA) or antigenic precursors [tumor antigen precursor proteins (TAPP)] could be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3714f5608d7b0d39a0cca1cc3aceba84
https://doi.org/10.1158/1078-0432.ccr-06-1576

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Antiangiogenic Drugs Synergize with a Membrane Macrophage Colony-Stimulating Factor-Based Tumor Vaccine to Therapeutically Treat Rats with an Established Malignant Intracranial Glioma

Autor: Samuel Chong, Tetyana Khomenko, Animesh Petkar, Chirag Shah, Neil Hoa, Jing-Li Zhuang, Christina Delgado, Seema Vohra, Jian Gang Zhang, Reza Alipanah, H. Terry Wepsic, Andre Obenaus, Edward W. B. Jeffes, Jessie Liu, Martin R. Jadus, Tuong-Vi Nguyen, Brandon A. Knight, Ramon Sanchez, Sakineh Khalaghizadeh

Publikováno v: The Journal of Immunology. 174:2533-2543

Combining a T9/9L glioma vaccine, expressing the membrane form of M-CSF, with a systemic antiangiogenic drug-based therapy theoretically targeted toward growth factor receptors within the tumor’s vasculature successfully treated >90% of the rats be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a591f135d145bc887ebae68de4de9dbf
https://doi.org/10.4049/jimmunol.174.5.2533

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Living T9 glioma cells expressing membrane macrophage colony-stimulating factor produce immediate tumor destruction by polymorphonuclear leukocytes and macrophages via a 'paraptosis'-induced pathway that promotes systemic immunity against intracranial T9 gliomas

Autor: Ramon Sanchez, Christina Delgado, Martin R. Jadus, H. Terry Wepsic, Christopher C. Williams, Ronald C. Kim, Yijun Chen, Qingcheng Xu, Michael T. Kleinman, Edward W. B. Jeffes, Thomas Douglass, Neary Arpajirakul, Qinghong Dan

Publikováno v: Blood. 100:1373-1380

Cloned T9-C2 glioma cells transfected with membrane macrophage colony-stimulating factor (mM-CSF) never formed subcutaneous tumors when implanted into Fischer rats, whereas control T9 cells did. The T9-C2 cells were completely killed within 1 day thr

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https://doi.org/10.1182/blood-2002-01-0174

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Development of Systemic Immunity to Glioblastoma Multiforme Using Tumor Cells Genetically Engineered to Express the Membrane-Associated Isoform of Macrophage Colony-Stimulating Factor

Autor: Martin R. Graf, Martin R. Jadus, John C. Hiserodt, H. Terry Wepsic, Gale A. Granger

Publikováno v: The Journal of Immunology. 163:5544-5551

We investigated the ability of Fischer rat T9 glioblastoma cells transduced with cDNA genes for the secreted (s) or membrane-associated (m) isoform of M-CSF to elicit an antitumor response when implanted into syngeneic animals. Intracranial (i.c.) im

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https://doi.org/10.4049/jimmunol.163.10.5544

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Macrophages that kill glioma cells expressing the membrane form of macrophage colony stimulating factor are resistant to prostaglandin E2 and interleukin-10

Autor: Maria D. Avina, Martin R. Jadus, H. Terry Wepsic, Christopher C. Williams, N.Sarena Zeineddine

Publikováno v: Immunology Letters. 70:63-68

Malignant rat T9 glioma cells retrovirally transduced with the membrane form of macrophage colony stimulating factor (mM-CSF) were killed by bone marrow derived macrophages in 24 h cytotoxicity assays. Prostaglandin E2 (PGE) and interleukin-10 (IL10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec32f6810f827e65059e6eb04118a67a
https://doi.org/10.1016/s0165-2478(99)00129-7

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Macrophages Kill T9 Glioma Tumor Cells Bearing the Membrane Isoform of Macrophage Colony Stimulating Factor Through a Phagocytosis-Dependent Pathway

Autor: Martin R. Jadus, Christopher C. Williams, Maria D. Avina, Mann Ly, Suzanna Kim, Ying Liu, Ryan Narasaki, Clifford A. Lowell, H. Terry Wepsic

Publikováno v: The Journal of Immunology. 160:361-368

Rat T9 glioma cells transfected with the gene for the membrane isoform of macrophage-CSF (mM-CSF) but not for the secreted isoform of M-CSF were directly killed by bone marrow-derived macrophages. Macrophage-mediated cytolysis of the mM-CSF-transfect

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https://doi.org/10.4049/jimmunol.160.1.361

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The identification of the neonatal NBXFO hybridoma cell and its mediator

Autor: Michael R. Irwin, Beverly E. Barton, Martin R. Jadus, Melanie C.N. Irwin, H. Terry Wepsic

Publikováno v: Developmental & Comparative Immunology. 19:261-277

The neonatal spleen:myeloma hybridoma cell, NBXFO, with immunosuppressive properties supported rodent hematopoietic colony formation. We identified this hybridoma to be an undifferentiated fibroblast that produced macrophage colony-stimulating factor

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https://doi.org/10.1016/0145-305x(95)00002-b

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Prostaglandin E2 induces up-regulation of murine macrophage β-endorphin receptors

Autor: Lawrence N. Parker, Martin R. Jadus, H. Terry Wepsic, Robert A. Gelfand

Publikováno v: Immunology Letters. 45:143-148

Cultured murine bone marrow macrophages specifically bound 125I-labeled beta-endorphin. Binding was displaceable by 100 times molar excess of full-length beta-endorphin but was insensitive to the opioid receptor antagonist, naloxone. Binding was inhi

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https://doi.org/10.1016/0165-2478(94)00245-m

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