Abstract OT2-19-05: A phase I/II trial of abemaciclib and T-DM1 in women and men with HER2-positive advanced or metastatic breast cancer that has progressed on treatment with a taxane, trastuzumab and pertuzumab (THP) (ACCRU-BR-1801)

Autor: Ciara C O Sullivan, Jun He, Vera J Suman, Krishna R Kalari, Roberto A Leon-Ferre, Jose C Villasboas-Bisneto, Pratima Chalasani, Demet Gokalp Yasar, Daniel M Anderson, Philip J Stella, Anthony J Jaslowski, Susan H Tannenbaum, Angela Saverimuthu, Donald Northfelt, Alvaro Moreno-Aspitia, Jodi M Carter, Minetta C Liu, Liewei Wang, Zhenkun Lou, Matthew P Goetz

Publikováno v: Cancer Research. 82:OT2-19

Background: Although major advances have been made in the treatment of HER2+ metastatic breast cancer (MBC), the goal of care remains largely palliative, therefore better treatments are needed. Given encouraging preclinical and clinical data, the com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e09d8da5752882f1223dbb4dfd1bd68
https://doi.org/10.1158/1538-7445.sabcs21-ot2-19-05

Everolimus in patients with rheumatoid arthritis receiving concomitant methotrexate: a 3-month, double-blind, randomised, placebo-controlled, parallel-group, proof-of-concept study

Autor: Øystein Førre, Rene Westhovens, M Bell, O Bjorneboe, F Caeiro, K H Abeywickrama, George A W Bruyn, G Tate, P Bernhardt, J Maldonado-Cocco, P.L.C.M. van Riel, PP Tak, H Tannenbaum

Publikováno v: Annals of the Rheumatic Diseases, 67, 1090-5
Annals of the Rheumatic Diseases, 67, 8, pp. 1090-5
Annals of the rheumatic diseases, 67(8), 1090-1095. BMJ Publishing Group

Contains fulltext : 70343.pdf (Publisher’s version ) (Closed access) OBJECTIVES: Everolimus, a proliferation signal inhibitor with disease-modifying properties, may be useful in treating rheumatoid arthritis (RA). This proof-of-concept study assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cd66f2b46982a5059aed43a19a59a2
https://doi.org/10.1136/ard.2007.078808

The perfect storm: hemophagocytic lymphohistiocytosis complicating disseminated yersiniosis

Autor: Michel, Bidros, Lisa M, Chirch, Maria T, Santos, Susan H, Tannenbaum

Publikováno v: Connecticut medicine. 78(3)

Hemophagocytic lymphohistio-cytosis (HLH) is a rare but serious medical condition with variable clinical outcome. HLH presents real diagnostic and therapeutic challenges to the treating physician despite the major advances in molecular laboratory tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d2bca996d1139811cbfd05a337f9b17
https://pubmed.ncbi.nlm.nih.gov/24772830

Fibrinolytic and Coagulant Responses to Regional Limb Perfusions of Tumor Necrosis Factor, Interferon-γ, and/or Melphalan

Autor: P. Merryman, Douglas L. Fraker, W. S. Arnold, McDonald K. Horne, S. H. Tannenbaum, Harvey R. Gralnick, Kelvin C. Yu, H R Alexander

Publikováno v: Thrombosis and Haemostasis. 77:053-056

SummaryRegional limb perfusion with antineoplastic agents stresses the local vasculature in a variety of ways. However, by monitoring the perfusates from limbs treated with melphalan alone or with melphalan plus tumor necrosis factor (TNF) and interf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2fd10e4cc75b2a63a61c20cac223ef9
https://doi.org/10.1055/s-0038-1655906

Die Verlaufsformen der Spondylodiszitis nach Bandscheibenoperation - zur Genese, Therapie und Prophylaxe

Autor: B. Ott-Tannenbaum, P. Gruss, R. Megele, H. Tannenbaum, A. Spohr, St. Gussmann, G. Gerhart, J. Tasler

Publikováno v: min - Minimally Invasive Neurosurgery. 35:79-84

Operations on lumbar disc prolapses are the most frequent operations in German neurosurgery divisions. After such operations, spondylodiscitis is a dreaded complication which is sometimes difficult to diagnose. Treatment of spondylodiscitis is always

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79a1b329db454e55c7161bcf6978bd3c
https://doi.org/10.1055/s-2008-1052252