Zobrazeno 1 - 10
of 31
pro vyhledávání: '"H. T. Andrew Cheung"'
Publikováno v:
ACS Infectious Diseases. 6:1922-1927
Schistosomiasis is a neglected tropical disease of considerable public health burden. We recently discovered a micromolar activity of several cardenolides against newly transformed schistosomula (NTS) of the parasitic flatworm Schistosoma mansoni in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adc85de1ef36905ae8e9d6e532d538b1
https://doi.org/10.1021/acsinfecdis.0c00175
https://doi.org/10.1021/acsinfecdis.0c00175
Autor:
Jennifer, Keiser, Vanessa, Koch, Anke, Deckers, H T Andrew, Cheung, Nicole, Jung, Stefan, Bräse
Publikováno v:
ACS Infectious Diseases
Schistosomiasis is a neglected tropical disease of considerable public health burden. We recently discovered a micromolar activity of several cardenolides against newly transformed schistosomula (NTS) of the parasitic flatworm Schistosoma mansoni in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e1fa1f3f03211948994caeb6fbd48c7
https://pubmed.ncbi.nlm.nih.gov/32364372
https://pubmed.ncbi.nlm.nih.gov/32364372
Publikováno v:
Cancer Chemotherapy and Pharmacology. 53:384-390
PC SPES is an eight-component herbal product marketed for the treatment of prostate cancer. The manufacturer of PC SPES claims that the herbal combination is a synergistic blend, but the purported synergy has never been tested. We examined the intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f227d67cc5962d953ffcbac57a54292
https://doi.org/10.1007/s00280-003-0746-1
https://doi.org/10.1007/s00280-003-0746-1
Publikováno v:
Photochemistry and Photobiology. 69:77-85
Methotrexate (MTX), a strong inhibitor of dihydrofolate reductase (DHFR), has been widely used for chemotherapy for many types of cancer as well as for juvenile rheumatoid arthritis. It mimics folate substrates and binds tightly to the active site of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6086aca61cd3f0a49524c86c75f0651
https://doi.org/10.1111/j.1751-1097.1999.tb05309.x
https://doi.org/10.1111/j.1751-1097.1999.tb05309.x
Autor:
Mary A. Smal, Martin H.N. Tattersall, Luc Escoffier, H. T. Andrew Cheung, Michael Costello, Yasuhisa Asano, Zhen Dong
Publikováno v:
Biochemical Pharmacology. 49:567-574
In an effort to improve the selectivity of the anticancer drug methotrexate (MTX), a series of potential prodrugs in which the 2-amino group was acylated with various α-amino acids (as well as l -pyroglutamic acid) was synthesized. Such derivatives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ab02dd2150c6e714cd36fbdbd98cf7
https://doi.org/10.1016/0006-2952(94)00456-v
https://doi.org/10.1016/0006-2952(94)00456-v
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :556-562
Epoxide-opening in 3β-acetoxy-16α,17α-epoxypregna-5,7-dien-20-one (3) and its Δ6,8(14)-isomer (7), as induced by boron trifluoride–acetic anhydride is accompanied by C-13 methyl migration. The product, 3β,16α-diacetoxy-17β-methyl-18-norpregn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afb347b719ec946b296b3fe3686caf62
https://doi.org/10.1039/p19800000556
https://doi.org/10.1039/p19800000556
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :251-256
The introduction of an hydroxy-group α to the 3-keto-function of the 5α- and the 5β-cardenolides uzarigenone (4) and digitoxigenone (15) was carried out in three steps in good overall yield. The dimethyl acetals (5) and (16) of uzarigenone and dig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f71ce7797a906ae381149de28c06b2
https://doi.org/10.1039/p19830000251
https://doi.org/10.1039/p19830000251
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :64-72
Afroside (2) has the same carbohydrate as gomphoside (1), namely a 4,6-dideoxyhexosulose doubly linked to the aglycone at the 2α and 3β positions. It differs from gomphoside in having a 15β-hydroxy-group, the location of which is shown by n.m.r. (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19149fd6e030f957aec2fd402471436e
https://doi.org/10.1039/p19810000064
https://doi.org/10.1039/p19810000064
Publikováno v:
Biological Mass Spectrometry. 12:11-18
The use of chemical ionization mass spectrometry for the characterization of analogues of methotreate, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, has been studied. With methane as reactant gas, abundant [MH]+ ions were ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c4daf6141591bb7045308792f169fc5
https://doi.org/10.1002/bms.1200120104
https://doi.org/10.1002/bms.1200120104
Publikováno v:
The Journal of Organic Chemistry. 43:1099-1105
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46d278f04734c9f8b10b7444d2694e7a
https://doi.org/10.1021/jo00400a017
https://doi.org/10.1021/jo00400a017