Development of a novel dosing paradigm to model diazepam rescue therapy in preclinical seizure and epilepsy models

Autor: Michelle Guignet, H. Steve White, Sunita N. Misra, Enrique Carrazana, Adrian L. Rabinowicz

Publikováno v: Epilepsia Open, Vol 9, Iss 4, Pp 1575-1581 (2024)

Abstract Diazepam is a cornerstone immediate‐use antiseizure rescue therapy that may extend the duration between seizure clusters in people living with epilepsy. However, our mechanistic understanding of intermittent rescue therapy on disease progr

Externí odkaz: https://doaj.org/article/60fb88bb593d439aa933753049e68f46

H. Steve White: A Champion for Contemporary Epilepsy Research.

Autor: Kohn H; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy and Department of Chemistry, University of North Carolina, Chapel Hill, NC, 27599, USA. harold_kohn@unc.edu.

Publikováno v: Neurochemical research [Neurochem Res] 2017 Jul; Vol. 42 (7), pp. 1869-1870. Date of Electronic Publication: 2017 Jan 25.

Antiepileptogenesis and disease modification: Progress, challenges, and the path forward—Report of the Preclinical Working Group of the 2018 NINDS‐sponsored antiepileptogenesis and disease modification workshop

Autor: Aristea S. Galanopoulou, Wolfgang Löscher, Laura Lubbers, Terence J. O’Brien, Kevin Staley, Annamaria Vezzani, Raimondo D’Ambrosio, H. Steve White, Harald Sontheimer, John A. Wolf, Roy Twyman, Vicky Whittemore, Karen S. Wilcox, Brian Klein

Publikováno v: Epilepsia Open, Vol 6, Iss 2, Pp 276-296 (2021)

Abstract Epilepsy is one of the most common chronic brain diseases and is often associated with cognitive, behavioral, or other medical conditions. The need for therapies that would prevent, ameliorate, or cure epilepsy and the attendant comorbiditie

Externí odkaz: https://doaj.org/article/9a03bf5010bf4758bf034af814a65c6f

Animal Models of Drug-Resistant Epilepsy as Tools for Deciphering the Cellular and Molecular Mechanisms of Pharmacoresistance and Discovering More Effective Treatments

Autor: Wolfgang Löscher, H. Steve White

Publikováno v: Cells, Vol 12, Iss 9, p 1233 (2023)

In the last 30 years, over 20 new anti-seizure medicines (ASMs) have been introduced into the market for the treatment of epilepsy using well-established preclinical seizure and epilepsy models. Despite this success, approximately 20–30% of patient

Externí odkaz: https://doaj.org/article/3a72507f8fd443d89f5cc4eb977b5a65

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

Autor: Valentina Iori, Anand M. Iyer, Teresa Ravizza, Luca Beltrame, Lara Paracchini, Sergio Marchini, Milica Cerovic, Cameron Hill, Mariella Ferrari, Massimo Zucchetti, Monica Molteni, Carlo Rossetti, Riccardo Brambilla, H. Steve White, Maurizio D'Incalci, Eleonora Aronica, Annamaria Vezzani

Publikováno v: Neurobiology of Disease, Vol 99, Iss , Pp 12-23 (2017)

We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability underlying seizures in rodents. Since this pathway is activated in neuron

Externí odkaz: https://doaj.org/article/6e1282d045224c0cb2029a5afa349aa9