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Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines

Autor: M Sartor, Joop Gaken, Saman Warnakulasuriya, H. Steingrimsdottir, Mahvash Tavassoli, M. Partridge, Nalin Thakker, Newell W. Johnson, F Elamin

Publikováno v: British Journal of Cancer

One of the most important components of G1 checkpoint is the retinoblastoma protein (pRB110). The activity of pRB is regulated by its phosphorylation, which is mediated by genes such as cyclin D1 and p16/MTS1. All three genes have been shown to be co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cdae6839562b3db9cf695e0d4e5a2d
https://doi.org/10.1038/sj.bjc.6690505

Molecular analysis of mutations in the CSB (ERCC6) gene in patients with Cockayne syndrome

Autor: Stefano Colella, Bianca Tanganelli, Miria Stefanini, H. Steingrimsdottir, Alan R. Lehmann, Donna L. Mallery, Christine Troelstra, Alain J. van Gool

Publikováno v: American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 1998, 62 (1), pp.77-85. ⟨10.1086/301686⟩
American Journal of Human Genetics, 62(1), 77-85. Cell Press

International audience; Cockayne syndrome is a multisystem sun-sensitive genetic disorder associated with a specific defect in the ability to perform transcription-coupled repair of active genes after UV irradiation. Two complementation groups (CS-A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bad3cb2c6d148a29f70d54c32741256
https://hdl.handle.net/1765/58099

Loss of heterozygosity on chromosome 5q in ovarian cancer is frequently accompanied by TP53 mutation and identifies a tumour suppressor gene locus at 5q13.1-21

Autor: Meryem Alagoz, X. Jiang, Farzin Farzaneh, H. Steingrimsdottir, Mahvash Tavassoli, E. Pierce, Ian G. Campbell

Publikováno v: British Journal of Cancer

Forty-nine ovarian tumours were examined for loss of heterozygosity (LOH) on chromosome 5 using eight microsatellite markers spanning both arms, including one at the APC locus. LOH on 5q was a frequent event, detectable in 23 of 49 (47%) tumours, whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c8f69d657ae011aab122b1b10a337b
https://doi.org/10.1038/bjc.1996.324

Mutations which alter splicing in the human hypoxanthine-guanine phosphoribosyltransferase gene

Autor: H. Steingrimsdottir, Gabriel Dorado, Alan R. Lehmann, J. Cole, G. Rowley

Publikováno v: Nucleic Acids Research. 20:1201-1208

A large proportion of mutations at the human hprt locus result in aberrant splicing of the hprt mRNA. We have been able to relate the mutation to the splicing abnormality in 30 of these mutants. Mutations at the splice acceptor sites of introns 4, 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd53145fae4d774cafd9f3895b004af8
https://doi.org/10.1093/nar/20.6.1201