β-delayed γ decay of 20Mg and the Ne19(p,γ)20Na breakout reaction in Type I X-ray bursts

Autor: B.E. Glassman, D. Pérez-Loureiro, C. Wrede, J. Allen, D.W. Bardayan, M.B. Bennett, B.A. Brown, K.A. Chipps, M. Febbraro, M. Friedman, C. Fry, M.R. Hall, O. Hall, S.N. Liddick, P. O'Malley, W.J. Ong, S.D. Pain, C. Prokop, S.B. Schwartz, P. Shidling, H. Sims, P. Thompson, H. Zhang

Publikováno v: Physics Letters B, Vol 778, Iss C, Pp 397-402 (2018)

Certain astrophysical environments such as thermonuclear outbursts on accreting neutron stars (Type-I X-ray bursts) are hot enough to allow for breakout from the Hot CNO hydrogen burning cycles to the rapid proton capture (rp) process. An important b

Externí odkaz: https://doaj.org/article/e8bee7d0ec134f36ab782be2c1c7be3a

Direct electrical stimulation evidence for a dorsal motor area with control of the larynx

Autor: J. Raouf Belkhir, W. Tecumseh Fitch, Frank E. Garcea, Benjamin L. Chernoff, Max H. Sims, Eduardo Navarrete, Sam Haber, David A. Paul, Susan O. Smith, Webster H. Pilcher, Bradford Z. Mahon

Publikováno v: Brain Stimulation, Vol 14, Iss 1, Pp 110-112 (2021)

Externí odkaz: https://doaj.org/article/209e16f911f44424b274ee3de0f0b425

On-treatment biomarkers can improve prediction of response to neoadjuvant chemotherapy in breast cancer

Autor: Richard J. Bownes, Arran K. Turnbull, Carlos Martinez-Perez, David A. Cameron, Andrew H. Sims, Olga Oikonomidou

Publikováno v: Breast Cancer Research, Vol 21, Iss 1, Pp 1-12 (2019)

Abstract Background Neoadjuvant chemotherapy is increasingly given preoperatively to shrink breast tumours prior to surgery. This approach also provides the opportunity to study the molecular changes associated with treatment and evaluate whether on-

Externí odkaz: https://doaj.org/article/222dc75295fc40e39ac1f9367c978a67

HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer

Autor: Edward J. Jarman, Carol Ward, Arran K. Turnbull, Carlos Martinez-Perez, James Meehan, Chrysi Xintaropoulou, Andrew H. Sims, Simon P. Langdon

Publikováno v: Breast Cancer Research, Vol 21, Iss 1, Pp 1-18 (2019)

Abstract Background Tumour hypoxia is a driver of breast cancer progression associated with worse prognosis and more aggressive disease. The cellular response to hypoxia is mediated by the hypoxia-inducible transcription factors HIF-1 and HIF-2, whos

Externí odkaz: https://doaj.org/article/923a851c858a45a7b0788fc90b57314e

RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells

Autor: Fuhui Chen, Sevim B. Gurler, David Novo, Cigdem Selli, Denis G. Alferez, Secil Eroglu, Kyriaki Pavlou, Jingwei Zhang, Andrew H. Sims, Neil E. Humphreys, Antony Adamson, Andrew Campbell, Owen J. Sansom, Cathy Tournier, Robert B. Clarke, Keith Brennan, Charles H. Streuli, Ahmet Ucar

Publikováno v: Chen, F, Gurler, S B, Novo, D, Selli, C, Alferez, D G, Eroglu, S, Pavlou, K, Zhang, J, Sims, A H, Humphreys, N E, Adamson, A, Campbell, A, Sansom, O J, Tournier, C, Clarke, R B, Brennan, K, Streuli, C H & Ucar, A 2023, ' RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells ', Oncogene, vol. 42, pp. 679-692 . https://doi.org/10.1038/s41388-022-02574-6

Breast cancer stem cells (BCSC) are presumed to be responsible for treatment resistance, tumor recurrence and metastasis of breast tumors. However, development of BCSC-targeting therapies has been held back by their heterogeneity and the lack of BCSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1327f89053608b065c8bcfc5ed3d5f
https://doi.org/10.1038/s41388-022-02574-6