Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro

Autor: Caroline N. Jones, Felix Ellett, Anne L. Robertson, Kevin M. Forrest, Kevin Judice, James M. Balkovec, Martin Springer, James F. Markmann, Jatin M. Vyas, H. Shaw Warren, Daniel Irimia

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients. Neutrophils play a critical role in control of infection but may be diminished in number and function during immunosuppressive therapies. Here, we me

Externí odkaz: https://doaj.org/article/47e6e17753be439a8ce215b1c7cd487e

Identification and interpretation of longitudinal gene expression changes in trauma.

Autor: Natasa Rajicic, Joseph Cuschieri, Dianne M Finkelstein, Carol L Miller-Graziano, Douglas Hayden, Lyle L Moldawer, Ernest Moore, Grant O'Keefe, Kimberly Pelik, H Shaw Warren, David A Schoenfeld, Inflammation and the Host Response to Injury Large Scale Collaborative Research Program

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14380 (2010)

RationaleThe relationship between leukocyte gene expression and recovery of respiratory function after injury may provide information on the etiology of multiple organ dysfunction.ObjectivesTo find a list of genes for which expression after injury pr

Externí odkaz: https://doaj.org/article/9b851f12d5c34fd287821d7fcdc79fb6

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes

Autor: Yousef Al-Abed, Shu Zhu, Yongjun Wang, Dominique P.V. de Kleijn, Daniel J. Antoine, Yaakov A. Levine, Jesse Roth, Kevin J. Tracey, Haichao Wang, Sangeeta S. Chavan, Wei Li, Manojkumar Gunasekaran, Mingzhu He, Peder S. Olofsson, Ulf Andersson, H. Shaw Warren, Meghan E. Addorisio, Huan Yang, Jianhua Li

Publikováno v: Yang, H, Wang, H, Levine, Y A, Gunasekaran, M K, Wang, Y, Addorisio, M, Zhu, S, Li, W, Li, J, de Kleijn, D P V, Olofsson, P S, Warren, H S, He, M, Al-Abed, Y, Roth, J, Antoine, D J, Chavan, S S, Andersson, U & Tracey, K J 2016, ' Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes ', JCI Insight, vol. 1, no. 7 . https://doi.org/10.1172/jci.insight.85375

Secreted by activated cells or passively released by damaged cells, extracellular HMGB1 is a prototypical damage-associated molecular pattern (DAMP) inflammatory mediator. During the course of developing extracorporeal approaches to treating injury a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13df20d91ed34b68e153ac4b7864dbdd
https://pubmed.ncbi.nlm.nih.gov/27294203

Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria

Autor: Laura Hermann, W. Conrad Liles, Kevin C. Kain, Michael Hawkes, Andrea L. Conroy, Chandy C. John, Sophie Namasopo, H. Shaw Warren, Robyn E. Elphinstone

Publikováno v: The Journal of Infectious Diseases

Background. Malaria remains a major cause of global mortality. Extracellular heme, released during malaria-induced hemolysis, mediates a number of pathogenic processes associated with vascular and organ injury. Hemopexin (hpx) facilitates the degrada

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3647f0a3d45e0c7b5a5398a6ceeda600
https://doi.org/10.1093/infdis/jiw357

Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis

Autor: Donald E. Ingber, Feng Huang, Sujatha R Thundivalappil, Nathan Brinkman, Michael Super, Tian Lin, Alexander L. Watters, H. Shaw Warren, Ann Smith, Jialin Liu, Tjitske S R van Engelen, Frank E. Riley

Publikováno v: Molecular Medicine, Vol 22, Iss 1, Pp 22-31 (2016)
Molecular medicine (Cambridge, Mass.), 22, 22-31. Feinstein Institute for Medical Research

Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible side effects related to protease activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f89917f9d3bdd77a1ddd7d81dec921b
http://link.springer.com/article/10.2119/molmed.2016.00006