Distinct Chemical Determinants are Essential for Achieving Ligands for Superior Optical Detection of Specific Amyloid-β Deposits in Alzheimer's Disease.

Autor: Wu X; Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden., Shirani H; Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden., Vidal R; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 46202, Indianapolis, Indiana, USA., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 46202, Indianapolis, Indiana, USA., Ingelsson M; Krembil Brain Institute, University Health Network, M5T 1 M8, Toronto, Ontario, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, M5T 0S8, Toronto, Ontario, Canada.; Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, SE-751 85, Uppsala, Sweden., Klingstedt T; Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden., Nilsson KPR; Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden.

Publikováno v: ChemistryOpen [ChemistryOpen] 2024 Nov 07, pp. e202400186. Date of Electronic Publication: 2024 Nov 07.

A new lipophilic gadolinium chelate as a tissue-specific contrast medium for MRI

Autor: Thomas Frenzel, Heinz Dr Gries, Hubert Dr Vogler, H. Schmitt-Willich, H.-J. Weinmann, Gabriele Schuhmann-Giampieri

Publikováno v: Magnetic Resonance in Medicine. 22:233-237

Gd-Ethoxybenzyl-DTPA (Gd-EOB-DTPA) is a highly water-soluble paramagnetic contrast agent. Due to its protein binding of about 10% and its lipophilic residue, Gd-EOB-DTPA exhibits both renal (30% of the dose) and hepatobiliary (70%) excretion in rats.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0131cd1f56a65b15a4ba8d00e58c2ddf
https://doi.org/10.1002/mrm.1910220214

Synthesis and Physicochemical Characterization of a New Gadolinium Chelate: The Liver-Specific Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA

Autor: J. Platzek, H. Schmitt-Willich, Detlev Sülzle, Günther Michl, Bernd Radüchel, Orlin Dr Petrov, Ch. L. J. Ewers, A. Müller-Fahrnow, M. Brehm

Publikováno v: Inorganic chemistry. 38(6)

A convenient synthesis of disodium S-[4-(4-ethoxybenzyl)-3,6,9-tris[(carboxy-kappaO)methyl]-3,6,9-triazaundecandioato)(5-)-kappa(3)N(3)(),N(6)(),N(9)(),kappa(2)O(1)(),O(11)()]gadolinate(2-) (Gd-EOB-DTPA), 1, is reported. This water-soluble complex is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c808b2821fb6faa4818119bef5373f
https://pubmed.ncbi.nlm.nih.gov/11670895

Stability of linear and macrocyclic gadolinium based contrast agents

Autor: H Schmitt-Willich

Publikováno v: The British Journal of Radiology. 80:581-582

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfb06f4709a1fa8fee442182bb482356
https://doi.org/10.1259/bjr/17326033

Pharmacokinetics in rats, dogs and monkeys of a gadolinium chelate used as a liver-specific contrast agent for magnetic resonance imaging

Autor: G, Schuhmann-Giampieri, T, Frenzel, H, Schmitt-Willich

Publikováno v: Arzneimittel-Forschung. 43(8)

The introduction of the lipophilic moiety, ethoxybenzyl, into the gadolinium chelate dimeglumine gadopentetate (Gd-DTPA, Magnevist, CAS 86050-77-3) yielded (4S) 4-(4-ethoxybenzyl)-3,6,9-tris (carboxylatomethyl)-3,6,9-triazaundecandioic acid, gadolini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::980350321354c521b1b1579bc556e791
https://pubmed.ncbi.nlm.nih.gov/8216456